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Chemical Structure| 514814-49-4 Chemical Structure| 514814-49-4

Structure of PMX 205
CAS No.: 514814-49-4

Chemical Structure| 514814-49-4

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PMX 205 is an antagonist of C5a receptor peptide with IC50 of 31 nM.

Synonyms: PMX 205

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Product Details of PMX 205

CAS No. :514814-49-4
Formula : C45H62N10O6
M.W : 839.04
SMILES Code : [H][C@@]1(C(N[C@H](CC2CCCCC2)C(N3)=O)=O)CCCN1C([C@@H](NC(CCC4=CC=CC=C4)=O)CCCNC([C@H](CCCNC(N)=N)NC([C@@H]3CC5=CNC6=CC=CC=C56)=O)=O)=O
Synonyms :
PMX 205
MDL No. :MFCD31657373

Safety of PMX 205

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335-H412
Precautionary Statements:P261-P264-P271-P273-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P403+P233-P405-P501

Isoform Comparison

Biological Activity

In Vivo:

Species
Animal Model
Administration Dosage Frequency Description References
BALB/c mice Snake envenomation model Subcutaneous injection 1 or 2 mg/kg body weight 24 hours and 1 hour before induction To assess the role of the C5a-C5aR1 axis in N. annulifera venom-induced local and systemic reactions. Results showed that PMX205 significantly reduced edema and systemic inflammatory responses and prevented the development of acute lung injury. Front Immunol. 2021 Apr 15;12:652242

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.19mL

0.24mL

0.12mL

5.96mL

1.19mL

0.60mL

11.92mL

2.38mL

1.19mL

 

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