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Chemical Structure| 24939-03-5 Chemical Structure| 24939-03-5

Structure of 24939-03-5

Chemical Structure| 24939-03-5

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Polyinosinic acid-polycytidylic acid is a TLR3 agonist and an immunostimulant. It is used in the form of its sodium salt to simulate viral infections.

Synonyms: Poly(I:C)

4.5 *For Research Use Only !

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Product Details of Polyinosinic-polycytidylic acid

CAS No. :24939-03-5
Formula : (C10H13N4O8P)x.(C9H14N3O8P)x
SMILES Code : NONE
Synonyms :
Poly(I:C)
MDL No. :MFCD00131957

Safety of Polyinosinic-polycytidylic acid

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H412
Precautionary Statements:P273-P301+P312+P330-P302+P352-P305+P351+P338

Related Pathways of Polyinosinic-polycytidylic acid

pyroptosis
TLR

Isoform Comparison

Biological Activity

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT01245673 Myeloma Phase 2 Active, not recruiting August 2018 United States, Maryland ... More >> University of Maryland Greenebaum Cancer Center Baltimore, Maryland, United States, 21201 United States, Pennsylvania Abramson Cancer Center of the University of Pennsylvania Philadelphia, Pennsylvania, United States, 19104 Less <<
NCT02425306 Melanoma Phase 1 Phase 2 Terminated(Slow accrual to par... More >>t 2 of the study. Accrual to part 1 is complete.) Less << - United States, Virginia ... More >> Cancer Center at the University of Virginia Charlottesville, Virginia, United States, 22908 Less <<
NCT03121677 Follicular Lymphoma Phase 1 Recruiting January 31, 2028 United States, Missouri ... More >> Washington University School of Medicine Recruiting Saint Louis, Missouri, United States, 63110 Contact: Todd A Fehinger, M.D., Ph.D.    314-362-5654    tfehnige@wustl.edu    Principal Investigator: Todd A Fehniger, M.D., Ph.D.          Sub-Investigator: Neha Mehta-Shah, M.D.          Sub-Investigator: Jeffrey Ward, M.D., Ph.D.          Sub-Investigator: Nancy L Bartlett, M.D.          Sub-Investigator: Brad Kahl, M.D.          Sub-Investigator: Amanda Cashen, M.D.          Sub-Investigator: Armin Ghobadi, M.D.          Sub-Investigator: John DiPersio, M.D., Ph.D.          Sub-Investigator: William E Gillanders, M.D.          Sub-Investigator: Malachi Griffith, Ph.D.          Sub-Investigator: Obi Griffith, Ph.D.          Sub-Investigator: Max Artyomov, Ph.D. Less <<
NCT02149225 Glioblastoma Phase 1 Completed - Denmark ... More >> Rigshospitalet, The Finsen Centre, Department of Oncology Copenhagen, Denmark, 2100 Germany Neurologische Klinik & Nationales Centrum für Tumorerkrankungen Heidelberg Heidelberg, Germany, 69120 Zentrum für Neurologie und Klinik für Neurochirurgie Tübingen, Germany, 72076 Netherlands Leiden University Medical Center, Department of Medical Oncology Leiden, Netherlands, 2333ZA Spain Vall d`Hebron University Hospital Barcelona, Spain, 08035 Switzerland Hôpitaux Universitaires de Genève Geneva 14, Switzerland, 1211 Less <<
NCT02643303 Head and Neck Squamous Cell Ca... More >>rcinoma Breast Cancer Sarcoma Merkel Cell Carcinoma Cutaneous T-Cell Lymphoma Melanoma Renal Cancer Bladder Cancer Prostate Cancer Lymphoma, Cutaneous T-Cell Less << Phase 1 Phase 2 Recruiting August 2022 United States, Georgia ... More >> Research Facility Recruiting Atlanta, Georgia, United States, 30322 United States, New York Research Facility Recruiting Buffalo, New York, United States, 14263 Research Facility Recruiting New York, New York, United States, 10029 United States, Ohio Research Facility Recruiting Cleveland, Ohio, United States, 44195 Contact: Shelley Robinson       robinss@ccf.org    United States, Virginia Research Facility Recruiting Charlottesville, Virginia, United States, 22908 Contact: Emily H. Allred, PhD, CCRC       eh4m@virginia.edu Less <<
NCT03721679 Solid Cancer Phase 1 Phase 2 Recruiting August 31, 2022 United States, Maryland ... More >> Chevy Chase RCCA Recruiting Chevy Chase, Maryland, United States, 20815 Contact: Frederick P Smith, MD    301-657-8587    fpsonc@aol.com    Contact: Susan Bendel, RN    301- 657- 8587    sbendel@regionalcancercare.org    Bay Hematology Oncology Recruiting Easton, Maryland, United States, 21601 Contact: David Smith, MD    410-820-5945    md@bayonc.com    Contact: Amy Wright, RN    410 820 5945 ext 4    amy@bayonc.com    United States, New York Icahn School of Medicine at Mount Sinai Not yet recruiting New York, New York, United States, 10029 Contact: Nina Bhardwaj, MD, PhD    212-824-8427    nina.bhardwaj@mssm.edu    Contact: Melissa Diamond    212 824 8449    melissa.diamond@mssm.edu    Principal Investigator: Nina Bhardwaj, MD, PhD Less <<
NCT03617328 Melanoma Phase 1 Phase 2 Recruiting March 8, 2021 United States, Virginia ... More >> University of Virgini Recruiting Charlottesville, Virginia, United States, 22908 Less <<
NCT00262730 - Completed - -
NCT00262730 Glioblastoma Multiforme Phase 2 Completed - United States, Alabama ... More >> Lurleen Wallace Comprehensive Cancer at University of Alabama-Birmingham Birmingham, Alabama, United States, 35294 United States, Florida H. Lee Moffitt Cancer Center and Research Institute at University of South Florida Tampa, Florida, United States, 33612-9497 United States, Georgia Winship Cancer Institute of Emory University Atlanta, Georgia, United States, 30322 United States, Maryland Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Baltimore, Maryland, United States, 21231-2410 United States, Massachusetts Massachusetts General Hospital Cancer Center Boston, Massachusetts, United States, 02114 United States, Michigan Josephine Ford Cancer Center at Henry Ford Hospital Detroit, Michigan, United States, 48202 United States, North Carolina Wake Forest University Comprehensive Cancer Center Winston-Salem, North Carolina, United States, 27157-1096 United States, Ohio Cleveland Clinic Taussig Cancer Center Cleveland, Ohio, United States, 44195 United States, Pennsylvania Abramson Cancer Center of the University of Pennsylvania Philadelphia, Pennsylvania, United States, 19104-4283 Less <<
NCT03599453 Triple -Negative Breast Cancer... More >> Estrogen Receptor Negative HER2/Neu Negative Anatomic Stage IV Breast Cancer AJCC Progesterone Receptor Negative Less << Phase 2 Not yet recruiting July 2022 -
NCT01810016 Unresectable or Metastatic Mel... More >>anoma Less << Phase 1 Terminated(Low recruitment due... More >> to change in standard of care) Less << - United States, New York ... More >> Mount Sinai Medical Center New York, New York, United States, 10029 Memorial Sloan-Kettering Cancer Center New York, New York, United States, 10065 United States, Pennsylvania University of Pittsburgh Cancer Center Pittsburgh, Pennsylvania, United States, 15213 United States, Virginia University of Virginia Cancer Center Charlottesville, Virginia, United States, 22908 Australia, Victoria Austin Health, Ludwig Oncology Unit Melbourne, Victoria, Australia Less <<
NCT02615574 Metastatic Colorectal Cancer Phase 2 Withdrawn(Due to inadequate su... More >>pply of drug) Less << December 2018 United States, Pennsylvania ... More >> Hillman Cancer Center Pittsburgh, Pennsylvania, United States, 15232 Less <<
NCT02129075 Cutaneous Melanoma ... More >> Mucosal Melanoma NY-ESO-1 Positive Tumor Cells Present Ocular Melanoma Stage IIB Cutaneous Melanoma AJCC v6 and v7 Stage IIC Cutaneous Melanoma AJCC v6 and v7 Stage III Cutaneous Melanoma AJCC v7 Stage IIIA Cutaneous Melanoma AJCC v7 Stage IIIB Cutaneous Melanoma AJCC v7 Stage IIIC Cutaneous Melanoma AJCC v7 Stage IV Cutaneous Melanoma AJCC v6 and v7 Less << Phase 2 Suspended(Drug supply issues) - United States, Illinois ... More >> University of Chicago Comprehensive Cancer Center Chicago, Illinois, United States, 60637 United States, New York Laura and Isaac Perlmutter Cancer Center at NYU Langone New York, New York, United States, 10016 Mount Sinai Hospital New York, New York, United States, 10029 United States, North Carolina Duke University Medical Center Durham, North Carolina, United States, 27710 United States, Ohio Cleveland Clinic Foundation Cleveland, Ohio, United States, 44195 United States, Oregon Providence Portland Medical Center Portland, Oregon, United States, 97213 United States, Wisconsin University of Wisconsin Hospital and Clinics Madison, Wisconsin, United States, 53792 Less <<
NCT03403634 Metastatic Carcinoma in the Li... More >>ver Recurrent Colorectal Carcinoma Stage IV Colorectal Cancer AJCC v7 Stage IVA Colorectal Cancer AJCC v7 Stage IVB Colorectal Cancer AJCC v7 Less << Early Phase 1 Recruiting December 1, 2019 United States, New York ... More >> Roswell Park Cancer Institute Recruiting Buffalo, New York, United States, 14263 Contact: Patrick M. Boland    716-845-1912    Patrick.Boland@roswellpark.org    Principal Investigator: Patrick M. Boland Less <<
NCT01810016 - Terminated(Low recruitment due... More >> to change in standard of care) Less << - -
NCT02334735 Melanoma Phase 2 Recruiting December 2019 United States, New York ... More >> New York University Langone Medical Center Active, not recruiting New York, New York, United States, 10016 Icahn School of Medicine at Mount Sinai Recruiting New York, New York, United States, 10029 Contact: Rhea Boxill, MPh    212-824-8448    rhea.boxill@mssm.edu    Principal Investigator: Nina Bhardwaj, MD, PhD Less <<
NCT03606967 Anatomic Stage IV Breast Cance... More >>r AJCC v8 Estrogen Receptor Negative HER2/Neu Negative Metastatic Triple-Negative Breast Carcinoma Progesterone Receptor Negative Prognostic Stage IV Breast Cancer AJCC v8 Less << Phase 2 Not yet recruiting July 31, 2019 -
NCT02510950 Glioblastoma Multiforme ... More >> Astrocytoma, Grade IV Less << Phase 1 Terminated(Low accrual) - United States, Missouri ... More >> Washington University School of Medicine Saint Louis, Missouri, United States, 63110 Less <<
NCT02721043 Solid Tumors Phase 1 Recruiting July 2020 United States, New York ... More >> Icahn School of Medicine at Mount Sinai Recruiting New York, New York, United States, 10029 Contact: Rhea Boxill, MPh    212-824-8448    rhea.boxill@mssm.edu    Principal Investigator: Nina Bhardwaj, MD, PhD Less <<
NCT00773097 Risk for Colorectal Cancer Phase 2 Completed - United States, Pennsylvania ... More >> Digestive Disorders Clinic Pittsburgh, Pennsylvania, United States, 15213 Less <<
NCT03422094 Glioblastoma Phase 1 Recruiting November 30, 2023 United States, Missouri ... More >> Washington University School of Medicine Recruiting Saint Louis, Missouri, United States, 63110 Contact: Gavin Dunn, M.D., Ph.D.    314-362-3570    gpdunn@wustl.edu    Contact: David J Schwab, CCRP    314-747-9912    dschwab@wustl.edu    Principal Investigator: Gavin Dunn, M.D., Ph.D.          Sub-Investigator: William E Gillanders, M.D.          Sub-Investigator: Robert Schreiber, Ph.D.          Sub-Investigator: Tanner M Johanns, M.D., Ph.D.          Sub-Investigator: Jian Campian, M.D., Ph.D.          Sub-Investigator: George Annstas, M.D.          Sub-Investigator: Milan G Chheda, M.D.          Sub-Investigator: Michael Chicoine, M.D.          Sub-Investigator: Ralph Dacey, M.D.          Sub-Investigator: Albert Kim, M.D., Ph.D.          Sub-Investigator: Keith Rich, M.D.          Sub-Investigator: Joshua Dowling, M.D.          Sub-Investigator: Eric Leuthardt, M.D.          Sub-Investigator: Gregory J Zipfel, M.D.          Sub-Investigator: Joshua Osbun, M.D.          Sub-Investigator: Christina Tsien, M.D.          Sub-Investigator: Jiayi Huang, M.D.          Sub-Investigator: Malachi Griffith, Ph.D.          Sub-Investigator: Obi Griffith, Ph.D. Less <<
NCT00773097 - Completed - -
NCT00553683 Breast Cancer ... More >> Colorectal Cancer Gastric Cancer Liver Cancer Melanoma (Skin) Metastatic Cancer Ovarian Cancer Pancreatic Cancer Less << Phase 1 Phase 2 Unknown July 2014 United States, New Jersey ... More >> Rutgrers University Hospital Newark, New Jersey, United States, 07101 Less <<
NCT00795457 Astrocytoma O... More >>ligo-Astrocytoma Glioma Less << Early Phase 1 Completed - United States, North Carolina ... More >> Comprehensive Cancer Center of Wake Forest University Winston-Salem, North Carolina, United States, 27157-1030 United States, Pennsylvania University of Pittsburgh Cancer Institute Pittsburgh, Pennsylvania, United States, 15232 Less <<
NCT00874861 Astrocytoma O... More >>ligoastrocytoma Oligodendroglioma Less << Early Phase 1 Completed - United States, Pennsylvania ... More >> UPMC Hillman Cancer Center (University of Pittsburgh Cancer Institute) Pittsburgh, Pennsylvania, United States, 15232 Less <<
NCT01130077 Newly Diagnosed Pediatric Pont... More >>ine Glioma Newly Diagnosed Pediatric High Grade Glioma Recurrent Pediatric High Grade Glioma Recurrent Pediatric Low Grade Glioma Less << Not Applicable Recruiting February 2020 United States, Pennsylvania ... More >> Children's Hospital of Pittsburgh of UPMC Recruiting Pittsburgh, Pennsylvania, United States, 15224 Contact: Mary Petrany, RN    412-692-8047    petranym@upmc.edu Less <<
NCT01410968 Metastatic Pancreatic Cancer Phase 1 Completed - United States, South Carolina ... More >> Medical University of South Carolina Charleston, South Carolina, United States, 29425 Less <<
NCT01846143 Melanoma Phase 1 Completed - United States, Virginia ... More >> University of Virginia Charlottesville, Virginia, United States, 22908 Less <<
NCT01532960 Breast Cancer Phase 1 Terminated(Futility for immune... More >> responses to the vaccine. Also, a component of study drug was in short supply.) Less << - United States, Virginia ... More >> University of Virginia Health System Charlottesville, Virginia, United States, 22908 Less <<
NCT02061449 Cutaneous T-cell Lymphoma Phase 1 Active, not recruiting March 2019 United States, New York ... More >> NYU Cancer Institute New York, New York, United States, 10016 Less <<
NCT03734692 Ovarian Cancer Recurrent Phase 1 Phase 2 Not yet recruiting November 20, 2023 United States, Pennsylvania ... More >> Magee-Womens Hospital of UPMC Not yet recruiting Pittsburgh, Pennsylvania, United States, 15213 Contact: Robert Edwards, MD    412-641-4212    edwarp@upmc.edu    Contact: Brenda Steele, RN    412-641-3418    steeleb@upmc.edu Less <<
NCT02427581 Triple Negative Breast Cancer ... More >> Triple Negative Breast Neoplasms Triple-Negative Breast Cancer Less << Phase 1 Suspended(Drugs not available) August 31, 2019 United States, Missouri ... More >> Washington University School of Medicine Saint Louis, Missouri, United States, 63110 Less <<
NCT02549833 Oligodendroglioma ... More >> Astrocytoma, Grade II Glioma, Astrocytic Glioma Malignant Glioma Oligoastrocytoma, Mixed Less << Phase 1 Recruiting December 1, 2020 United States, California ... More >> University of California Recruiting San Francisco, California, United States, 94143 Contact: Ute Vogrinec, RN    877-827-3222    clinicaltrials@ucsf.edu    Contact: Jane Rabbitt, BSN    415-353-2652    Jane.Rabbitt@ucsf.edu    Principal Investigator: Hideho Okada, MD, PhD          Principal Investigator: Jennie Taylor, MD Less <<
NCT02661100 Non Small Cell Lung Cancer ... More >> Advanced Triple Negative Breast Cancer Small Cell Lung Cancer Urothelial Cancer Mesothelioma Malignant Melanoma Less << Phase 1 Phase 2 Withdrawn(Drug unavailable) July 2018 -
NCT02924038 Glioma Malign... More >>ant Glioma Astrocytoma, Grade II Oligodendroglioma Glioma, Astrocytic Oligoastrocytoma, Mixed Less << Phase 1 Recruiting September 2020 United States, California ... More >> University of California Recruiting San Francisco, California, United States, 94143 Contact: Laura Sit, MS       Laura.Sit@ucsf.edu    Contact: Jane Rabbitt, BSN    (415) 353-2652    Jane.Rabbitt@ucsf.edu Less <<
NCT03223103 Glioblastoma Phase 1 Recruiting May 22, 2020 United States, New York ... More >> Icahn School of Medicine at Mount Sinai Recruiting New York, New York, United States, 10029 Contact: Angela Stangarone, MPH    212-824-8579    angela.stangarone@mssm.edu    Principal Investigator: Adilia Hormigo, MD, PhD Less <<
NCT02358187 Low Grade Glioma Phase 2 Recruiting January 2020 United States, Pennsylvania ... More >> Children's Hospital of Pittsburgh of UPMC Recruiting Pittsburgh, Pennsylvania, United States, 15224 Contact: Mary Petrany, RN    412-692-8047    petranym@upmc.edu Less <<
NCT03665545 Glioblastoma Multiforme ... More >> Glioblastoma, Adult Glioma of Brain Glioblastoma Multiforme of Brain Less << Phase 1 Phase 2 Recruiting November 10, 2023 Switzerland ... More >> University Hospitals of Geneva Recruiting Geneva, Switzerland, 1211 Contact: Cristina Riccadonna, PhD    +41(0)223722910    Cristina.Riccadonna@hcuge.ch Less <<
NCT01677962 Pancreatic Adenocarcinoma Non-... More >>resectable Less << Phase 1 Completed - United States, South Carolina ... More >> Medical University of South Carolina Charleston, South Carolina, United States, 29425 Less <<
NCT00000713 HIV Infections Phase 1 Completed - United States, Pennsylvania ... More >> Univ of Pittsburgh Med School Pittsburgh, Pennsylvania, United States Less <<
NCT03206047 Recurrent Fallopian Tube Carci... More >>noma Recurrent Ovarian Carcinoma Recurrent Primary Peritoneal Carcinoma Less << Phase 1 Phase 2 Suspended(Pending outcome of t... More >>he DLT period) Less << March 31, 2020 United States, Arizona ... More >> University of Arizona Cancer Center-North Campus Tucson, Arizona, United States, 85719 The University of Arizona Medical Center-University Campus Tucson, Arizona, United States, 85724 United States, California University of California Davis Comprehensive Cancer Center Sacramento, California, United States, 95817 United States, Illinois University of Chicago Comprehensive Cancer Center Chicago, Illinois, United States, 60637 UC Comprehensive Cancer Center at Silver Cross New Lenox, Illinois, United States, 60451 University of Chicago Medicine-Orland Park Orland Park, Illinois, United States, 60462 United States, Kansas University of Kansas Clinical Research Center Fairway, Kansas, United States, 66205 United States, Nebraska Nebraska Medicine-Village Pointe Omaha, Nebraska, United States, 68118 University of Nebraska Medical Center Omaha, Nebraska, United States, 68198 United States, New Jersey Rutgers Cancer Institute of New Jersey New Brunswick, New Jersey, United States, 08903 United States, New York Roswell Park Cancer Institute Buffalo, New York, United States, 14263 Memorial Sloan Kettering Cancer Center New York, New York, United States, 10065 United States, Ohio Ohio State University Comprehensive Cancer Center Columbus, Ohio, United States, 43210 United States, Pennsylvania University of Pittsburgh Cancer Institute (UPCI) Pittsburgh, Pennsylvania, United States, 15232 United States, Utah Huntsman Cancer Institute/University of Utah Salt Lake City, Utah, United States, 84112 Less <<
NCT03068832 Pediatric Brain Tumor Phase 1 Not yet recruiting May 31, 2023 United States, Missouri ... More >> Washington University School of Medicine Not yet recruiting Saint Louis, Missouri, United States, 63110 Contact: Karen M Gauvain, M.D., MSPH    314-454-2002    gauvaink@wustl.edu    Principal Investigator: Karen M Gauvain, M.D., MSPH          Sub-Investigator: Joshua Rubin, M.D., Ph.D.          Sub-Investigator: Tanner M Johanns, M.D., Ph.D.          Sub-Investigator: William E Gillanders, M.D.          Sub-Investigator: Robert Schreiber, Ph.D.          Sub-Investigator: Maxim Artyomov, Ph.D.          Sub-Investigator: David Spencer, M.D., Ph.D.          Sub-Investigator: David Limbrick, M.D., Ph.D.          Sub-Investigator: Allison King, M.D., MPH          Sub-Investigator: Milan Chheda, M.D.          Sub-Investigator: George Ansstas, M.D.          Sub-Investigator: Jian Campian, M.D. Less <<
NCT00002269 HIV Infections Not Applicable Completed - United States, Florida ... More >> Miami Veterans Administration Med Ctr Miami, Florida, United States, 33125 United States, Oregon Oregon Health Sciences Univ Portland, Oregon, United States, 97201 United States, Pennsylvania MCP Hahnemann Univ Hosp Philadelphia, Pennsylvania, United States, 19102 United States, Texas Nelson Tebedo Community Clinic Dallas, Texas, United States, 75219 Dr Patricia Salvato Houston, Texas, United States, 77054 Less <<
NCT00000735 HIV Infections Phase 1 Completed - United States, District of Col... More >>umbia George Washington Univ Med Ctr Washington, District of Columbia, United States, 20037 United States, Pennsylvania Milton S Hershey Med Ctr Hershey, Pennsylvania, United States, 170330850 Less <<
NCT03162562 Cancer of Ovary ... More >> Neoplasms, Ovarian Ovarian Cancer Stage IV Ovarian Cancer Recurrent Ovarian Cancer Stage III Ovary Cancer Less << Phase 1 Recruiting September 2021 United States, Florida ... More >> Florida Hospital Cancer Institute Recruiting Orlando, Florida, United States, 32804 Contact: Susan Coakley, MHA, CCRP    407-303-2090    Susan.coakley@flhosp.org    Principal Investigator: Robert Holloway, MD          United States, Virginia VCU Massey Cancer Center, Dalton Oncology Clinic Recruiting Richmond, Virginia, United States, 23298 Contact: William P. McGuire, MD    804-828-4642    william.mcguire@vcuhealth.org    Contact: Melanie R. Hamilton, RN    804-628-6434    mrhamilton2@vcu.edu    Principal Investigator: William P. McGuire, MD Less <<
NCT00052715 - Terminated(prematurely discont... More >>inued after results of the EORTC phase-3 study defined the SOC for newly diagnosed GMB pts as RT plus concomitant and adjuvant TMZ) Less << - -
NCT00052715 Brain and Central Nervous Syst... More >>em Tumors Less << Phase 2 Terminated(prematurely discont... More >>inued after results of the EORTC phase-3 study defined the SOC for newly diagnosed GMB pts as RT plus concomitant and adjuvant TMZ) Less << - United States, California ... More >> UCSF Comprehensive Cancer Center San Francisco, California, United States, 94115 Less <<
NCT00058123 Brain and Central Nervous Syst... More >>em Tumors Less << Phase 2 Completed - United States, California ... More >> Jonsson Comprehensive Cancer Center at UCLA Los Angeles, California, United States, 90095-1781 UCSF Comprehensive Cancer Center San Francisco, California, United States, 94115 United States, Massachusetts Dana-Farber/Harvard Cancer Center at Dana Farber Cancer Institute Boston, Massachusetts, United States, 02115 United States, New York Memorial Sloan-Kettering Cancer Center New York, New York, United States, 10021 United States, Pennsylvania Hillman Cancer Center at University of Pittsburgh Cancer Institute Pittsburgh, Pennsylvania, United States, 15232 United States, Texas M.D. Anderson Cancer Center at University of Texas Houston, Texas, United States, 77030-4009 University of Texas Health Science Center at San Antonio San Antonio, Texas, United States, 78284-6220 United States, Wisconsin University of Wisconsin Comprehensive Cancer Center Madison, Wisconsin, United States, 53792-6164 Less <<
NCT00493545 Cervical Intraepithelial Neopl... More >>asia Less << Phase 1 Unknown June 2008 United States, California ... More >> University of Southern California Los Angeles, California, United States, 90033 Medical Center for Clinical Research San Diego, California, United States, 92108 United States, Georgia Medical College of Georgia Augusta, Georgia, United States, 30912 United States, New York Montefiore Medical Center New York, New York, United States, 10461 United States, Oklahoma University of Oklahoma Health Sciences Center (OUHSC) / OU Medical Center Oklahoma City, Oklahoma, United States, 73104 United States, Texas Baylor College of Medicine Houston, Texas, United States, 77030 United States, Utah Mt Timpanagos Women's Health Center Pleasant Grove, Utah, United States, 84062 Salt Lake Women's Center S. Salt Lake, Utah, United States, 84070 Less <<
NCT00646152 Influenza Sev... More >>ere Acute Respiratory Distress Syndrome Smallpox Ebola Unknown Respiratory Viruses Less << Phase 1 Completed - United States, Maryland ... More >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 Less <<
NCT00948961 Advanced Malignancies Phase 1 Phase 2 Completed - United States, Connecticut ... More >> Yale Comprehensive Cancer Center New Haven, Connecticut, United States, 06519-1717 United States, Florida Mount Sinai Comprehensive Cancer Center Miami Beach, Florida, United States, 33140 United States, Michigan Henry Ford Health System Detroit, Michigan, United States, 48202 United States, New York Memorial Sloan Kettering Cancer Center New York, New York, United States, 10017 Weill Cornell Cancer Center New York, New York, United States, 10065 United States, North Carolina Carolina BioOncology Institute, PLLC Huntersville, North Carolina, United States, 28078 United States, Oregon Providence Portland Cancer Center Portland, Oregon, United States, 97213 Less <<
NCT01127464 HIV-1 Infection ... More >> HIV Infection Healthy Volunteers Less << Phase 1 Completed - United States, New York ... More >> Rockefeller University New York, New York, United States, 10065 Less <<
NCT01355393 HER2-positive Breast Cancer ... More >> Male Breast Cancer Recurrent Breast Cancer Stage II Breast Cancer Stage IIIA Breast Cancer Stage IIIB Breast Cancer Stage IIIC Breast Cancer Stage IV Breast Cancer Less << Phase 1 Phase 2 Active, not recruiting - United States, Washington ... More >> Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium Seattle, Washington, United States, 98109 Less <<
NCT01734564 Neoplasms Phase 2 Completed - Spain ... More >> Clinica Universidad de Navarra Pamplona, Navarra, Spain, 31008 Less <<
NCT03358719 Acute Myeloid Leukemia ... More >> Blasts 30 Percent or Less of Bone Marrow Nucleated Cells Chronic Myelomonocytic Leukemia High Risk Myelodysplastic Syndrome Myelodysplastic Syndrome Refractory Anemia Less << Phase 1 Recruiting September 13, 2020 United States, New York ... More >> Roswell Park Cancer Institute Recruiting Buffalo, New York, United States, 14263 Contact: Elizabeth A. Griffiths    716-845-3996    Elizabeth.Griffiths@roswellpark.org    Principal Investigator: Elizabeth A. Griffiths Less <<
NCT01783431 Melanoma Phase 1 Terminated(The study was termi... More >>nated early due to low accrual.) Less << - United States, South Carolina ... More >> Medical University of South Carolina Charleston, South Carolina, United States, 29425 Less <<
NCT01984892 Melanoma Squa... More >>mous Cell Carcinoma of the Head and Neck Squamous Cell Carcinoma of the Skin Sarcoma of the Skin Basal Cell Cancer of the Skin Breast Cancer Less << Phase 2 Terminated(PI discretion, low ... More >>enrollment) Less << - United States, New York ... More >> Icahn School of Medicine at Mount Sinai New York, New York, United States, 10029 Less <<
NCT01984892 - Terminated(PI discretion, low ... More >>enrollment) Less << - -
NCT01920191 CNS Tumor, Adult Phase 1 Phase 2 Completed - Switzerland ... More >> Geneva University Hospitals, Centre of Oncology Geneva, Switzerland, CH-1211 Less <<
NCT01188096 Brain Tumors Phase 2 Active, not recruiting July 2019 United States, California ... More >> RADY Children's Hospital San Diego, California, United States, 92123 United States, Georgia Children's Healthcare of Atlanta Atlanta, Georgia, United States, 30342 Less <<
NCT01834248 Acute Myeloid Leukemia ... More >> Alkylating Agent-Related Acute Myeloid Leukemia Chronic Myelomonocytic Leukemia Myelodysplastic Syndrome Refractory Anemia With Excess Blasts in Transformation Less << Phase 1 Completed - United States, New York ... More >> Roswell Park Cancer Institute Buffalo, New York, United States, 14263 Less <<
NCT02071095 - Completed - -
NCT00215800 Chronic Fatigue Syndrome ... More >> Myalgic Encephalomyelitis Less << Phase 3 Completed - -
NCT00215813 - - - United States, Nevada ... More >> Sierra Internal Medicine Incline Village, Nevada, United States, 89451 Contact: Glenda Hill    775-832-4886    ghill@sierrainternalmed.com    Principal Investigator: Daniel Peterson, MD          United States, North Carolina Hunter-Hopkins Center, PA Charlotte, North Carolina, United States, 28210 Contact: Wendy Springs    704-543-9692    wendy@drlapp.net    Principal Investigator: Charles Lapp, MD Less <<
NCT02071095 HIV-1 Infected Adults With Chr... More >>onic HIV-1 Infection Less << Phase 1 Phase 2 Completed - United States, New York ... More >> The Rockefeller University Hospital New York, New York, United States, 10065 Less <<
NCT00058123 - Completed - -
NCT02166905 Fallopian Tube Carcinoma ... More >> Ovarian Carcinoma Primary Peritoneal Carcinoma Less << Phase 1 Phase 2 Recruiting February 12, 2021 United States, New York ... More >> Roswell Park Cancer Institute Recruiting Buffalo, New York, United States, 14263 Contact: Roswell Park    877-275-7724    ASKRPCI@RoswellPark.org    Principal Investigator: Kunle Odunsi Less <<
NCT01842139 Adult Acute Myeloid Leukemia i... More >>n Remission Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities Adult Acute Myeloid Leukemia With Del(5q) Adult Acute Myeloid Leukemia With Inv(16)(p13;q22) Adult Acute Myeloid Leukemia With t(15;17)(q22;q12) Adult Acute Myeloid Leukemia With t(16;16)(p13;q22) Adult Acute Myeloid Leukemia With t(8;21)(q22;q22) Less << Phase 1 Completed - United States, Illinois ... More >> University of Chicago Chicago, Illinois, United States, 60637-1470 Less <<
NCT01591473 Influenza, Human Phase 1 Phase 2 Terminated(The CDC indicated n... More >>asal spray flu vaccine should not be used during 2016-2017) Less << - United States, Alabama ... More >> The University of Alabama at Birmingham Birmingham, Alabama, United States, 35294 Less <<
NCT00986609 Breast Cancer ... More >> Inflammatory Breast Cancer Stage I Breast Cancer Stage II Breast Cancer Stage IIIA Breast Cancer Stage IIIB Breast Cancer Stage IIIC Breast Cancer Triple-negative Breast Cancer Less << Early Phase 1 Completed - United States, Ohio ... More >> Case Medical Center, University Hospitals Seidman Cancer Center, Case Comprehensive Cancer Center Cleveland, Ohio, United States, 44106 Less <<
NCT01976585 Low-Grade B-cell Lymphoma Phase 1 Phase 2 Recruiting November 2020 United States, New York ... More >> Icahn School of Medicine at Mount Sinai Recruiting New York, New York, United States, 10029 Principal Investigator: Joshua Brody, MD Less <<
NCT00094003 Liver Neoplasms ... More >> Neoplasm Metastasis Local Neoplasm Recurrences Less << Phase 1 Completed - United States, New Hampshire ... More >> Dartmouth-Hitchcock Medical Center Lebanon, New Hampshire, United States, 03756 United States, Texas MD Anderson Cancer Center Houston, Texas, United States, 77030 Less <<
NCT02657161 Rabies Phase 1 Completed - Singapore ... More >> SingHealth Investigational Medicine Unit Singapore, Singapore, 169608 Less <<
NCT01012700 Healthy Volunteers Phase 1 Completed - United States, New York ... More >> The Rockefeller University New York, New York, United States, 10065 Less <<
NCT02956421 Rabies Phase 2 Completed - Singapore ... More >> SingHealth Investigational Medicine Unit Singapore, Singapore, 169608 Clinical Trials & Research Unit Singapore, Singapore, 529889 Less <<
NCT01079741 - Completed - -
NCT00616941 - Completed - -
NCT02754362 Glioblastoma ... More >>Glioma Less << Phase 2 Active, not recruiting December 2018 United States, New York ... More >> NYU Perlmutter Cancer Center New York, New York, United States, 10016 Less <<
NCT02834052 Metastatic Colon Cancer ... More >> Solid Tumor Less << Phase 1 Phase 2 Recruiting January 2021 United States, Georgia ... More >> Georgia Cancer Center at Augusta University Recruiting Augusta, Georgia, United States, 30912 Contact: Sandy Wall, RN, ADN    706-721-4430    swall@augusta.edu    Principal Investigator: Asha Nayak, MD          Sub-Investigator: Sharad Ghamande, MD Less <<
NCT01079741 Melanoma Phase 1 Phase 2 Completed - United States, New York ... More >> New York University Langone Medical Center New York, New York, United States, 10016 Less <<
NCT02078648 Adult Brain Glioblastoma ... More >> Glioblastoma Multiforme Less << Phase 1 Phase 2 Completed - United States, Alabama ... More >> University of Alabama Birmingham, Alabama, United States, 35294 United States, Arizona Barrow Neurological Institute Phoenix, Arizona, United States, 85013 Center for Neurosciences Tucson, Arizona, United States, 85718 United States, California Cedars Sinai Medical Center Los Angeles, California, United States, 90048 United States, District of Columbia George Washington University Washington, District of Columbia, United States, 20052 United States, Florida University of Florida Gainesville, Florida, United States, 32611 United States, Georgia Piedmont Cancer Institute Atlanta, Georgia, United States, 30309 United States, Illinois Northwestern University Chicago, Illinois, United States, 60208 United States, Massachusetts Dana Farber Cancer Institute Boston, Massachusetts, United States, 02115 United States, Michigan Henry Ford Health System Detroit, Michigan, United States, 48202 United States, New York Columbia University Medical Center New York, New York, United States, 10027 United States, Ohio Cleveland Clinic Cleveland, Ohio, United States, 44195 United States, Pennsylvania University of Pittsburgh Medical Center Pittsburgh, Pennsylvania, United States, 15260 United States, Rhode Island Rhode Island Hospital Providence, Rhode Island, United States, 02903 United States, Texas Baylor Charles A Sammons Cancer Center Dallas, Texas, United States, 75246 United States, Virginia University of Virginia Charlottesville, Virginia, United States, 22904- Less <<
NCT00374049 Prostate Cancer Phase 1 Completed - United States, Pennsylvania ... More >> Hillman Cancer Center Pittsburgh, Pennsylvania, United States, 15232 Less <<
NCT02090374 Allergic Rhinitis ... More >> Asthma Latent Tuberculosis Less << Not Applicable Completed - United Kingdom ... More >> Imperial Clinical Respiratory Research Unit (ICRRU), St Mary's Hospital Paddington, London, United Kingdom, W2 1NY Less <<
NCT00616941 Epithelial Ovarian Cancer ... More >> Fallopian Tube Cancer Primary Peritoneal Cancer Less << Phase 1 Completed - United States, New York ... More >> Memorial Sloan-Kettering Cancer Center New York, New York, United States, 10021 Less <<
NCT00880867 B Cell Lymphoma ... More >> T Cell Lymphoma Less << Phase 1 Terminated(Low enrollment) - United States, Nevada ... More >> Nevada Cancer Institute Las Vegas, Nevada, United States, 89135 Less <<
NCT03338556 - Completed - -
NCT01720836 Non-small Cell Lung Cancer (NS... More >>CLC) Less << Phase 1 Phase 2 Recruiting September 2020 United States, Pennsylvania ... More >> UPMC Hillman Cancer Center Recruiting Pittsburgh, Pennsylvania, United States, 15232 Less <<
NCT03338556 Viral Upper Respiratory Tract ... More >>Infection Less << Phase 2 Completed - United Kingdom ... More >> hVIVO Services Limited, QMB Innovation Centre London, United Kingdom, E1 2AX Less <<
NCT02423863 Melanoma Head... More >> and Neck Cancer Sarcoma Non-Melanoma Skin Cancers Less << Phase 2 Recruiting December 2020 United States, Maryland ... More >> Chevy Chase RCCA Recruiting Chevy Chase, Maryland, United States, 20815 Contact: Frederick P Smith, MD    301-657-8587    fpsonc@aol.com    Contact: Susan Bendel, RN    301- 657- 8587    sbendel@regionalcancercare.org    Dermatologic Surgery Center Washington DC Recruiting Chevy Chase, Maryland, United States, 20815 Contact: Maral K Skelsey, MD    301-652-8081    dr.maral.skelsey@mohs-md.com    Contact: Xiaophin Bai, MD    301 652 8081    officemanager@mohs-md.com    Bay Hematology Oncology Recruiting Easton, Maryland, United States, 2160l Contact: David Smith, MD    410-820-5945    md@bayonc.com    Contact: Amy Wright, RN    410 820 5945 ext 4    amy@bayonc.com    United States, Missouri University of Missouri School of Medicine Recruiting Columbia, Missouri, United States, 65211-0001 Contact: Kevin Staveley-O'Carroll, MD    843-696-8164    staveleyocarrollk@health.missouri.edu    United States, New York Icahn School of Medicine at Mount Sinai Recruiting New York, New York, United States, 10029 Contact: Nina Bhardwaj, MD, PhD    212-824-8427    nina.bhardwaj@mssm.edu    Contact: Erlinda Sacris, RN,OCN    212 824 9359    erlinda.sacris@mssm.edu    Principal Investigator: Nina Bhardwaj, MD, PhD          United States, Pennsylvania University of Pittsburgh Medical Center Recruiting Pittsburgh, Pennsylvania, United States, 15232 Contact: Melissa Burgess,, MD    412-623-3205    burgessma@upmc.edu    United States, South Carolina Medical University of South Carolina Not yet recruiting Charleston, South Carolina, United States, 29425-8150 Contact: John Wrangle, MD, MPH    843-792-7786    wrangle@musc.edu Less <<
NCT03198676 Upper Respiratory Tract Infect... More >>ions Less << Phase 1 Completed - United Kingdom ... More >> Quotient Clinical Nottingham, United Kingdom, NG11 6JS Less <<
NCT03131765 Cancer Phase 1 Recruiting December 2019 Singapore ... More >> National University Cancer Institute Singapore Recruiting Singapore, Singapore Contact: Lee Soo Chin    67795555       Principal Investigator: Lee Soo Chin Less <<
NCT00035893 HIV Seropositivity ... More >> HIV Infection Less << Phase 2 Completed - United States, California ... More >> Orange County Center for Special Immunology Fountain Valley, California, United States, 92708 AltaMed Health Services Corporation Los Angeles, California, United States, 90022 United States, Connecticut Circle Medical Center Norwalk, Connecticut, United States, 06851 United States, District of Columbia Dupont Circle Physicians Group Washington, District of Columbia, United States, 20009 United States, Florida Julia Torres, MD Fort Lauderdale, Florida, United States, 33306 Allied Clinical Trials Miami, Florida, United States, 33156 Scott Ubillos, MD Tampa, Florida, United States, 33607 United States, New Jersey St. Michael's Medical Center Newark, New Jersey, United States, 07102 Christopher Lucasti, D.O. Somers Point, New Jersey, United States, 08244 United States, Pennsylvania W. Chris Woodward, DO Reading, Pennsylvania, United States, 19601 Less <<
NCT00035581 HIV Seropositivity ... More >> HIV Infection Less << Phase 2 Terminated - United States, California ... More >> Orange County Center for Special Immunology Fountain Valley, California, United States, 92708 United States, Connecticut Circle Medical Center Norwalk, Connecticut, United States, 06851 United States, District of Columbia Dupont Circle Physicians Group Washington, District of Columbia, United States, 20009 United States, Florida Julia Torres, MD Fort Lauderdale, Florida, United States, 33306 Scott Ubillos, MD Tampa, Florida, United States, 33607 United States, New Jersey St. Michael's Medical Center Newark, New Jersey, United States, 07102 United States, Pennsylvania W. Chris Woodward, DO Reading, Pennsylvania, United States, 19601 Less <<
NCT01008527 Melanoma Phase 1 Completed - United States, Florida ... More >> H. Lee Moffitt Cancer Center & Research Institute Tampa, Florida, United States, 33612 Less <<
NCT03262103 Prostate Cancer Phase 1 Recruiting May 1, 2020 United States, New York ... More >> Icahn School of Medicine at Mount Sinai Recruiting New York, New York, United States, 10029 Contact: Cynthia Knauer, RN, MS    212-241-0751    cynthia.knauer@mountsinai.org    Contact: Julia Wagner    212-659-8307    julia.wagner@mountsinai.org    Principal Investigator: Ashutosh K Tewari, MD Less <<
NCT03732547 Carcinoma, Hepatocellular Phase 2 Recruiting October 22, 2023 China, Zhejiang ... More >> The second affiliated hospital of Zhejiang University Recruiting Hangzhou, Zhejiang, China, 310000 Contact: Liang Wen, MD PhD    +8619967413613    11518214@zju.edu.cn Less <<
NCT00694551 Prostate Cancer Not Applicable Active, not recruiting December 2019 United States, Florida ... More >> H. Lee Moffitt Cancer Center & Research Institute Tampa, Florida, United States, 33612 Puerto Rico Ponce School of Medicine Ponce, Puerto Rico, 00716 Less <<
NCT01437605 Melanoma Phase 2 Active, not recruiting July 2020 United States, Florida ... More >> H. Lee Moffitt Cancer Center and Research Institute Tampa, Florida, United States, 33612 Less <<
NCT00694551 - Active, not recruiting - -
NCT01299662 Healthy Volunteers Phase 1 Completed - United States, New York ... More >> The Rockefeller University New York, New York, United States, 10065 Less <<
NCT02532413 Chronic Hepatitis B Phase 4 Unknown August 2017 China, Hubei ... More >> Department of Infectious Disease of Wu Han Union Hospital Recruiting Wuhan, Hubei, China, 430022 Contact: Xin Zheng, M.D.    (00)-86-02785726732    zheng2015uh@163.com    Contact: Jin Tian, M.S.    (00)-86-02785726132    tjxhtj@126.com Less <<

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.49mL

0.30mL

0.15mL

7.45mL

1.49mL

0.74mL

14.89mL

2.98mL

1.49mL

Dissolving Methods
The prepared working fluid is recommended to be prepared now and used up as soon as possible in a short period of time. The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1

References

 

Historical Records

Categories