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Chemical Structure| 2645-32-1 Chemical Structure| 2645-32-1

Structure of PR-619
CAS No.: 2645-32-1

Chemical Structure| 2645-32-1

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PR-619 is a broad-spectrum and reversible inhibitor of the deubiquitinylating enzymes (DUBs) with EC50 of 1-20 μM and it was developed for chemotherapy.

Synonyms: 2,6-Diamino-3,5-dithiocyanopyridine; DUB Inhibitor V

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Product Details of PR-619

CAS No. :2645-32-1
Formula : C7H5N5S2
M.W : 223.28
SMILES Code : NC1=NC(N)=C(SC#N)C=C1SC#N
Synonyms :
2,6-Diamino-3,5-dithiocyanopyridine; DUB Inhibitor V
MDL No. :MFCD00830384
InChI Key :ZXOBLNBVNROVLC-UHFFFAOYSA-N
Pubchem ID :2817763

Safety of PR-619

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H317-H319
Precautionary Statements:P280-P305+P351+P338

Isoform Comparison

Biological Activity

Target
  • DUB

    Plpro, EC50:14.2 μM

  • UCH

    UCH-L3, EC50:2.95 μM

    UCH-L5, EC50:12.8 μM

  • USP/UBP

    USP28, EC50:6.24 μM

    USP5, EC50:4.90 μM

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

4.48mL

0.90mL

0.45mL

22.39mL

4.48mL

2.24mL

44.79mL

8.96mL

4.48mL

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