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There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Chemical Structure| 192329-42-3 Chemical Structure| 192329-42-3

Structure of Prinomastat
CAS No.: 192329-42-3

Chemical Structure| 192329-42-3

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Prinomastat is a spectrum inhibitor of MMP with IC50s of 79, 6.3 and 5.0 nM for MMP-1, MMP-3 and MMP-9 respectively.

Synonyms: AG3340; KB-R9896

4.5 *For Research Use Only !

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Product Details of Prinomastat

CAS No. :192329-42-3
Formula : C18H21N3O5S2
M.W : 423.51
SMILES Code : O=C([C@@H]1N(S(=O)(C2=CC=C(OC3=CC=NC=C3)C=C2)=O)CCSC1(C)C)NO
Synonyms :
AG3340; KB-R9896
MDL No. :MFCD08690607

Safety of Prinomastat

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H360
Precautionary Statements:P201-P308+P313
Class:6.1
UN#:2811
Packing Group:

Isoform Comparison

Biological Activity

In Vitro:

Cell Line
Concentration Treated Time Description References
HL60 cells 10, 50, 100, 200 μg/ml 72 hours Evaluate the effect of Prinomastat on HL60 cell proliferation, showing reduced growth at higher concentrations Blood Adv. 2022 May 24;6(10):3126-3141

In Vivo:

Species
Animal Model
Administration Dosage Frequency Description References
Mice CR2-TAg transgenic mice Oral 3 mg/ml From 6 weeks of age, changed every two weeks, continued until 24 weeks AG3340/Prinomastat treatment reduced tumor burden, prolonged survival, decreased lung metastasis, and decreased blood vessel density. Cancer Res. 2010 Mar 15;70(6):2224-34

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.36mL

0.47mL

0.24mL

11.81mL

2.36mL

1.18mL

23.61mL

4.72mL

2.36mL

 

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