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CAS No. :	1921-70-6
Formula :	C₁₉H₄₀
M.W :	268.52
SMILES Code :	CC(CCCC(CCCC(CCCC(C)C)C)C)C
Synonyms :	Norphytane
MDL No. :	MFCD00008952

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H315-H319
Precautionary Statements:	P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313

Mice	SJL/J mice	Intraperitoneal injection	0.5 mL	Single injection, observed for 16 weeks	To study the impact of Xist RNP on autoimmune pathology in the pristane-induced SLE model. Results showed that pristane injection coupled with tgXist expression in males led to higher incidence and severity of glomerulonephritis, hepatic lipogranulomas, and pulmonary hemorrhage, reflecting disease damage observed in severe SLE patients.	Cell. 2024 Feb 1;187(3):733-749. e16
BALB/c mice	Pristane-induced SLE model	Intraperitoneal injection	0.5 mL	Single injection, lasted for 24 weeks	The pristane-induced SLE model simulates human SLE manifestations, including proteinuria, serositis, and glomerulonephritis. Dietary OLA supplementation improved kidney damage and endothelial dysfunction.	Antioxidants (Basel). 2023 Jun 19;12(6):1303
C57BL/6 mice	Pristane-induced lupus nephritis model	Intraperitoneal injection	0.5 mL	Single injection	To induce lupus nephritis model, results showed that pristane injection led to increased proteinuria, renal function impairment, and renal pathological changes.	Front Immunol. 2021 Jul 5;12:683249.
C57BL/6 mice	Pristane-induced DAH model	Intraperitoneal injection	0.5 mL	Single injection, observed until day 14	To evaluate the therapeutic potential of miR-146a in DAH. Results showed that intra-pulmonary miR-146a delivery could suppress DAH by reducing TRAF6, IL-8, NETs and apoptosis expression.	J Biomed Sci. 2022 Aug 26;29(1):62
Mice	CD38-deficient mice	Intraperitoneal injection	0.5 mL	Single dose, observed for 2 weeks	To study pristane-induced lupus-like disease, finding that CD38-deficient mice showed milder inflammatory responses compared to wild-type mice	Front Immunol. 2022 Oct 24;13:1013236
Mice (C57BL/6 background)	Pristane-induced lupus model	Intraperitoneal injection	0.5 mL	Single injection, observed for 10 months	To evaluate the impact of OGG1 deficiency on lupus-like inflammatory responses, showing enhanced inflammation and skin pathology in Ogg1?/? mice	Front Immunol. 2020 Sep 24;11:554725
Mice	Pristane-induced diffuse alveolar hemorrhage model	Intraperitoneal injection	0.5 mL	Single injection, observed for 7 days	To evaluate the role of ER stress in pristane-induced lung injury. Results showed increased expression of ER stress markers (e.g., Chop and Bip) in the lungs of pristane-treated mice, correlating with neutrophil infiltration.	Front Immunol. 2022 Feb 3;13:790043
Mice	Pristane-induced lupus model	Intraperitoneal injection	0.5 mL	Single injection, observed for 6 months	Study the role of autophagy in the maintenance of autoreactive memory B cells and lupus development	Front Immunol. 2021 Jul 16;12:701066
C57BL/6 mice	Pristane-induced lupus model	Intraperitoneal injection	0.5 mL	Single injection, observed for 14 days	Studied the effect of Pristane on monocyte differentiation and DAH, showing that Pristane treatment increased circulating Ly6C?CD138+ monocytes, associated with DAH susceptibility	Elife. 2022 Oct 20;11:e76205
CBA/Igb mice	Pristane-induced arthritis model	Intraperitoneal injection	0.5 mL	Two injections, 50 days apart	To investigate whether Pristane-induced arthritis is dependent on CD4+ T cells. Results showed that Pristane-induced arthritis depends on the presence of CD4+ T cells.	Immunology. 1997 Jan;90(1):81-6
C57BL/6 mice	Pristane-induced acute SLE-like lung inflammation model	Intraperitoneal injection	0.5 mL	Single injection, observed at 3, 7, and 14 days	To evaluate the effect of Pristane on lung inflammation, results showed that Pristane treatment led to reduced miR-125a expression, enhanced IL-16 expression, and increased neutrophil infiltration in the lungs.	JCI Insight. 2018 Aug 9;3(15):e120798
BALB/c mice	Pristane-induced lupus model	Intraperitoneal injection	0.5 mL	Single injection	Induce lupus-like disease and evaluate cognitive impairment and features of neuropsychiatric lupus	Int J Mol Sci. 2024 Dec 5;25(23):13080
BALB/c mice	Pristane-induced lupus model	Intraperitoneal injection	0.5 mL	Single injection, observed at 1, 2, 4, or 8 months	To investigate whether the pristane-induced lupus model is suitable for neuropsychiatric lupus (NPSLE) studies. Results showed that PIL mice exhibited olfactory dysfunction, anxiety- and depression-like behavior, and pathological changes in the brain.	Behav Brain Funct. 2023 Feb 10;19(1):3
BALB/c mice	Pristane induced lupus mouse model	Intraperitoneal injection	0.5 mL	Single injection, lasting for 4 months	To study the effects of Pristane-induced lupus mouse model on neuroinflammation and behavioral deficits. Results showed that Pristane-induced lupus mice exhibited olfactory dysfunction, anxiety- and depression-like behaviors, as well as neuroinflammation and brain pathological changes.	Behav Brain Funct. 2023 Jun 15;19(1):11
C57BL/6 mice	Pristane-induced SLE model	Intraperitoneal injection	0.5mL	Single injection, sacrificed on Day 7	To evaluate the effect of GSK-J4 on ISG expression in the Pristane-induced SLE model, results showed that GSK-J4 reduced ISG expression in peritoneal monocytes	Arthritis Rheumatol. 2024 Mar;76(3):396-410
Dark Agouti rats	Pristane-induced arthritis model	Intradermal injection	100 µL	Single injection, monitored for 15 weeks	To investigate the effect of pre-existing periodontitis on the development and immune/inflammatory response of pristane-induced arthritis. Results showed that pre-existing periodontitis did not affect the development or severity of arthritis.	J Transl Med. 2016 Nov 3;14(1):311
Rats	Pristane-induced arthritis model	Intradermal injection	150 μl	Single injection, monitored for 90 days or longer	To study the chronic course, histopathological features, and genetic influences of pristane-induced arthritis. Results showed arthritis onset within 2-3 weeks post-injection, characterized by chronic, relapsing, and progressive joint inflammation with bone and cartilage erosions.	Am J Pathol. 1996 Nov;149(5):1675-83
Sprague-Dawley rats	Pristane-induced arthritis model	Intradermal injection	300 µL	Administered on day 0 and day 4	To induce arthritis and assess disease severity, results showed successful establishment of pristane-induced arthritis model for evaluating therapeutic effects	NPJ Regen Med. 2022 Feb 2;7(1):13
C57BL/6 mice	Pristane-induced lupus model	Intraperitoneal injection	500 µL	Single injection, lasting 8 months	To study the impact of cGAS deficiency on lupus pathology. Results showed that Cgas-/- mice exhibited more severe pulmonary hemorrhage, autoantibody production, and inflammatory cell infiltration, indicating cGAS deficiency exacerbates lupus pathology.	Front Immunol. 2022 Dec 16;13:1010764
C57BL/6 mice	Pristane-induced lupus model	Intraperitoneal injection	500 µL	Single injection, lasted for 6 months	To investigate the effect of iron deficiency on the disease progression of pristane-induced lupus, results showed that iron deficiency improved renal damage, reduced autoantibody production, and promoted Treg cell expansion.	Front Immunol. 2022 Feb 28;13:799331
Mice	Pristane-induced lupus model	Intraperitoneal injection	500 µL	Single injection, duration of 6 months	To investigate the role of type III interferons in pristane-induced lupus model. Results showed improved survival rates, reduced lipogranuloma formation, and decreased early-phase autoantibody titers in Ifnlr1?/? mice.	Int J Mol Sci. 2021 Oct 29;22(21):11747
Mice	Systemic lupus erythematosus model	Intraperitoneal injection	500 μl	Single injection	Induction of systemic lupus erythematosus symptoms, including proteinuria, elevated levels of antinuclear antibodies (ANAs) and anti-dsDNA antibodies, and kidney inflammation and immune complex deposition. AIM2 deficiency ameliorated these symptoms.	Signal Transduct Target Ther. 2021 Sep 14;6(1):341
Mice	Pristane-induced lupus nephritis model	Intraperitoneal injection	500 μl	Single injection, observation period up to 9 months	To evaluate the effect of Pristane on inflammation and immune responses in NLRP12-deficient mice, results showed NLRP12-deficient mice exhibited more severe inflammation and immune responses	J Clin Invest. 2023 Feb 1;133(3):e157272
Mice	Pristane-induced lupus model	Intraperitoneal injection	500 μl	Single injection	To investigate the role of AIM2 in lupus development, results showed that AIM2 deficiency ameliorated lupus symptoms	Clin Transl Med. 2022 Mar;12(3):e781
C57BL/6 mice	Pristane-induced lupus nephritis model	Intraperitoneal injection	500 μl	Single injection, lasting for 4 months	To study the Pristane-induced lupus nephritis model for evaluating the therapeutic effect of exosomes derived from BMMSCs on lupus nephritis.	Stem Cell Res Ther. 2022 Sep 24;13(1):484
BALB/c mice	Pristane-induced lupus nephritis model	Intraperitoneal injection	500 μL	Single injection	To evaluate the effects of Pristane on lupus nephritis, results showed that Pristane-induced LN mice exhibited severe renal damage, including glomerulonephritis and tubular inflammation.	Int J Mol Sci. 2019 Jul 15;20(14):3466
Mice	Dnase1–/–Dnase1L3–/– double-knockout mice	Intraperitoneal injection	500 μL	Single dose	Accelerated disease phenotype, resulting in 50% mortality in untreated DKO mice, while LBme-treated DKO mice showed reduced mortality to 15%	JCI Insight. 2024 Jun 18;9(14):e177003

Bio Calculators
Preparing Stock Solutions		1mg	5mg	10mg
Preparing Stock Solutions	1 mM 5 mM 10 mM	3.72mL 0.74mL 0.37mL	18.62mL 3.72mL 1.86mL	37.24mL 7.45mL 3.72mL
Dissolving Methods	Animal experiment Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn: in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day; The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound. Protocol 1 Protocol 2

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CAS No.: 1921-70-6

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CAS No.: 1921-70-6

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Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed