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Chemical Structure| 1260667-65-9 Chemical Structure| 1260667-65-9

Structure of 1260667-65-9

Chemical Structure| 1260667-65-9

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Product Details of [ 1260667-65-9 ]

CAS No. :1260667-65-9
Formula : C5H4ClIN2
M.W : 254.46
SMILES Code : NC1=NC=C(Cl)C(I)=C1
MDL No. :MFCD18250085
InChI Key :PMLVDYBLXQYWLI-UHFFFAOYSA-N
Pubchem ID :53445165

Safety of [ 1260667-65-9 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P280-P301+P312-P302+P352-P305+P351+P338

Application In Synthesis of [ 1260667-65-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1260667-65-9 ]

[ 1260667-65-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1260667-65-9 ]
  • [ 261165-05-3 ]
  • tert-butyl ((1R,3S)-3-((5-chloro-4-iodopyridin-2-yl)carbamoyl)cyclopentyl)carbamate [ No CAS ]
YieldReaction ConditionsOperation in experiment
64% With pyridine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; In ethyl acetate; at 17 - 25℃; for 24h; T3P (?50 wt % in ethyl acetate; 2.60 mL, 4.36 mmol) was added to a solution of 5-chloro-4-iodopyridin-2-amine (694 mg, 2.18 mmol; prepared according to Example 2), <strong>[261165-05-3](1S,3R)-3-((tert-butoxycarbonyl)amino)cyclopentanecarboxylic acid</strong> (500 mg, 2.18 mmol) and pyridine (0.71 mL, 8.7 mmol) in EtOAc (10 mL). The resulting solution was stirred at r.t. for 24 h. The reaction mixture was diluted with saturated aqueous ammonium chloride (25 mL) and extracted with EtOAc (50 mL). The organic layer was dried over MgSO4, filtered, and concentrated under reduced pressure to afford tert-butyl ((1R,3S)-3-((5-chloro-4-iodopyridin-2-yl)carbamoyl)cyclopentyl)carbamate (650 mg, 64%). 1H NMR (400 MHz, DMSO-d6, 30 C.) 1.39 (9H, s), 1.46-1.63 (2H, m), 1.74-183 (3H, m), 2.04-2.17 (1H, m), 2.90-3.00 (1H, m), 3.70-3.84 (1H, m), 6.73-6.82 (1H, m), 8.39 (1H, s), 8.73 (1H, s), 10.68 (1H, s). m/z: ES+[M+H]+ 466.
 

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Related Functional Groups of
[ 1260667-65-9 ]

Chlorides

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Amines

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Iodides

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Related Parent Nucleus of
[ 1260667-65-9 ]

Pyridines

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