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Chemical Structure| 158093-65-3 Chemical Structure| 158093-65-3

Structure of PU139
CAS No.: 158093-65-3

Chemical Structure| 158093-65-3

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PU139 is a broad-spectrum histone acetyltransferase (HAT) inhibitor that blocks Gcn5, p300/CBP-associated factor (PCAF), CBP, and p300 with IC50 values of 8.39, 9.74, 2.49, and 5.35 μM, respectively, suitable for research on cancer and gene regulation.

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Product Details of PU139

CAS No. :158093-65-3
Formula : C12H7FN2OS
M.W : 246.26
SMILES Code : O=C1N(C2=CC=C(F)C=C2)SC3=NC=CC=C31
MDL No. :N/A

Safety of PU139

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Related Pathways of PU139

epigenetics

Isoform Comparison

Biological Activity

Description
PU139 is a strong inhibitor of pan-histone acetyltransferase (HAT). It effectively inhibits the HATs Gcn5, p300/CBP-associated factor (PCAF), CREB (cAMP response element-binding) protein (CBP), and p300 with IC50 values of 8.39, 9.74, 2.49, and 5.35 μM, respectively [1][2].

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

4.06mL

0.81mL

0.41mL

20.30mL

4.06mL

2.03mL

40.61mL

8.12mL

4.06mL

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