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CAS No. :	1085412-37-8
Formula :	C₃₁H₃₂N₈O₅
M.W :	596.64
SMILES Code :	O=C(C1=CC(OCCN)=CC(C(NC2=NC3=C(C(OCCN)=C2)C=CC=C3)=O)=N1)NC4=CC(OCCN)=C5C=CC=CC5=N4
Synonyms :	RR82
MDL No. :	MFCD25976689

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H315-H319-H335
Precautionary Statements:	P261-P305+P351+P338

Astrocytes	2 µM	Overnight	PDS downregulates Atg7 mRNA and ATG7 protein levels	Autophagy. 2020 Dec;16(12):2252-2259
Neurons	2 µM	Overnight	PDS downregulates Atg7 expression and reduces autophagy	Autophagy. 2020 Dec;16(12):2252-2259
IPAM cells	10 µM	12 hours	To evaluate the stabilizing effect of PDS on the PRRSV-G4 structure and its impact on viral replication. Results showed that PDS treatment significantly inhibited PRRSV replication.	Nucleic Acids Res. 2023 Oct 27;51(19):10752-10767
HeLa cells	20 µM	12 hours	To investigate the effect of Pyridostatin on the interaction between G3BP1 and rG4 structures, results showed that Pyridostatin could displace G3BP1 from mRNA, with the most pronounced effects observed in the 3'-untranslated regions (3'-UTR) of mRNAs.	Nucleic Acids Res. 2021 Nov 8;49(19):11323-11336
HEK293T cells	20 µM	12 hours	To investigate the effect of Pyridostatin on the interaction between G3BP1 and rG4 structures, results showed that Pyridostatin could displace G3BP1 from mRNA, with the most pronounced effects observed in the 3'-untranslated regions (3'-UTR) of mRNAs.	Nucleic Acids Res. 2021 Nov 8;49(19):11323-11336
U2OS human osteosarcoma cell line	1 µM	12 hours	Pyridostatin-α formed nuclear foci in cells, co-localizing with hPif1.	Nat Chem Biol. 2012 Feb 5;8(3):301-10
DLD1 BRCA2−/−	2 µM	16 hours	Evaluate the effect of Pyridostatin on DNA damage in BRCA2−/− cells, showing significant increase in DNA breaks, repaired after 72 hours	EMBO Mol Med. 2022 Mar 7;14(3):e14501
DLD1 BRCA2+/+	2 µM	16 hours	Evaluate the effect of Pyridostatin on DNA damage in BRCA2+/+ cells, showing no significant increase in DNA breaks	EMBO Mol Med. 2022 Mar 7;14(3):e14501
RPE-1 BRCA1−/−	10 µM	2 days	Evaluate DNA damage and immune responses induced by Pyridostatin in BRCA1-deficient cells, showing increased KAP1 Ser824 and IRF3 Ser386 phosphorylation	EMBO Mol Med. 2022 Mar 7;14(3):e14501
A549	10 µM	2 hours H2O2 treatment, 4 hours recovery	To study the effect of PDS (rG4 structure stabilizer) on FEN1 expression, results showed that PDS pretreatment upregulated FEN1 expression.	Antioxidants (Basel). 2023 Jan 26;12(2):276
HeLa cancer cells	10 µM	24 hours	Applied mass spectrometry (MS) based quantitative proteomics to profile the protein expression of HeLa cells subjected to PDS treatment. Results showed that PDS significantly downregulated 22 proteins but upregulated 16 proteins.	Nucleic Acids Res. 2022 Apr 8;50(6):3070-3082
PK-15 CD163 cells	10 µM	24 hours	To investigate the effect of PDS on PRRSV replication. Results showed that PDS treatment significantly reduced viral RNA levels and protein expression.	Nucleic Acids Res. 2023 Oct 27;51(19):10752-10767
Murine B16-F10 melanoma cells	10 µM	24 hours	To study the immune gene activation effect of PDS in murine melanoma cells, showing PDS activated STING translocation and immune gene expression in wild-type B16 cells but not in STING knockout cells.	Nucleic Acids Res. 2021 Jul 9;49(12):6673-6686
Human MRC5 normal lung cells	10 µM	24 hours	To determine the immune gene activation effect of PDS in normal cells, showing only IFNB gene was activated and secreted IFNB protein levels were much lower than in MCF-7 cells.	Nucleic Acids Res. 2021 Jul 9;49(12):6673-6686
Human MCF-7 breast cancer cells	10 µM	24 hours	To measure the cytotoxic potency of PDS, showing its IC50 is 81.6 μM. At a lower dose of 10 μM, PDS only slightly affected MCF-7 cell growth but increased the levels of G4 and γH2AX (phosphorylated S139 H2AX histone) foci.	Nucleic Acids Res. 2021 Jul 9;49(12):6673-6686
HEK293T cells	5 µM	24 hours	To evaluate the effect of the PA-PDS conjugate ligand on the regulation of gene expression in the hTERT 5-12 DNA promoter region. Results showed that the PA-PDS conjugate ligand significantly reduced Renilla luciferase activity more than PA or PDS alone.	Nucleic Acids Res. 2024 Oct 14;52(18):10775-10787
HepG2 cells	20 µM	24 hours	To investigate the effect of PDS on RNAPII-mediated long-range DNA contacts, results showed that PDS treatment significantly reduced DNA contacts involving G4 structure loci.	Nucleic Acids Res. 2023 Sep 8;51(16):8434-8446
HeLa cells	100 µM	24 hours	Assessed the effect of Pyridostatin on cell survival, showing increased sensitivity in USP50-depleted cells	Nat Commun. 2024 Sep 16;15(1):8102
SV40-transformed human MRC5 fibroblasts	2 µM	24 hours	Pyridostatin promoted growth arrest via inducing replication- and transcription-dependent DNA damage, leading to G2 phase cell cycle arrest.	Nat Chem Biol. 2012 Feb 5;8(3):301-10
H1299+shBRCA2 DOX	10 µM	3 days	Evaluate the activation of immune responses by Pyridostatin in BRCA2-deficient cells, showing increased IRF3 Ser386 phosphorylation	EMBO Mol Med. 2022 Mar 7;14(3):e14501
Human telomere DNA	100 nM	30 minutes	To evaluate the binding of Pyridostatin (PDS) to telomeric G-quadruplex and its inhibitory effect on DNA polymerase. Results showed that the dissociation constant Kd of PDS was 440 ±80 nM, and at 100 nM concentration, 18.7% of G-quadruplex was bound to PDS.	Nucleic Acids Res. 2019 Apr 23;47(7):3295-3305
Human telomeric G-quadruplex	20 nM to 2 µM	30 seconds	To determine the dissociation constant of PDS with G-quadruplex, results showed Kd of 490±80 nM	Nat Chem. 2011 Aug 28;3(10):782-7
Human telomeric G-quadruplex	0.5 µM	30 seconds	To evaluate the effect of PDS on the mechanical stability of G-quadruplex, results showed increased mechanical stability of PDS-bound G-quadruplex	Nat Chem. 2011 Aug 28;3(10):782-7
HEK293T cells	2 µM or 10 µM	4 days	To study the effect of PDS on DNA damage and cell cycle in RAD51-deficient cells	Mol Cell. 2016 Feb 4;61(3):449-460
HepG2 cells	20 µM	48 hours	To investigate the effect of PDS on HsACBP transcription, results showed that PDS significantly inhibited HsACBP transcription	Nucleic Acids Res. 2022 Jul 8;50(12):6953-6967
MDA-MB-231 breast cancer cell line	2 µM	48 hours	Pyridostatin significantly reduced SRC-dependent cellular motility.	Nat Chem Biol. 2012 Feb 5;8(3):301-10
DLD1 cells	2 µM	48 hours	To study the DNA damage response and cell cycle effects of PDS in BRCA2-deficient cells	Mol Cell. 2016 Feb 4;61(3):449-460
Various cancer cell lines	2 µM	72 hours	Pyridostatin inhibited cell proliferation and induced apoptosis in some cells.	Nat Chem Biol. 2012 Feb 5;8(3):301-10
HT1080 fibrosarcoma cells	0.89 µM (GI50)	72 hours	Evaluate the growth inhibition effect of PDS family ligands, PDSI showed the strongest growth inhibition	J Am Chem Soc. 2013 Jul 3;135(26):9640-3

Silkworm (Bombyx mori)	Fifth instar larvae	Injection	2, 4 or 6 μl of 15 mM	Single injection, observed at 12, 24 and 36 hours post-injection	To investigate the effect of PDS on larval development and lipid metabolism, results showed that PDS treatment led to reductions in fat body mass, body size and weight, and growth and metamorphic rates	Nucleic Acids Res. 2022 Jul 8;50(12):6953-6967
CB17-SCID mice	DLD1 BRCA2−/− xenograft tumours	Intravenous injection	7.5 mg/kg/day	Five consecutive days, followed by 2-day break and five more days of treatment	Evaluate the inhibitory effect of Pyridostatin on BRCA2-deficient tumours, showing significant suppression of tumour growth	EMBO Mol Med. 2022 Mar 7;14(3):e14501

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CAS No.: 1085412-37-8

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CAS No.: 1085412-37-8

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Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed