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Chemical Structure| 65-22-5 Chemical Structure| 65-22-5
Chemical Structure| 65-22-5

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Pyridoxal hydrochloride is an endogenous metabolite.

Synonyms: Pyridoxal (hydrochloride); Pyridoxal hydrochloride; HQ

4.5 *For Research Use Only !

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Product Citations

Product Citations

Humberto De Vitto ; Kafi K. J. Belfon ; Nandini Sharma ; Sarah Toay ; Jan Abendroth ; David. M. Dranow , et al.

Abstract: Thiamin and its phosphate derivatives are ubiquitous molecules involved as essential cofactors in many cellular processes. The de novo biosynthesis of thiamin employs the parallel synthesis of 4-methyl-5-(2-hydroxyethyl)thiazole (THZ-P) and 4-amino-2-methyl-5(diphosphooxymethyl) pyrimidine (HMP) pyrophosphate (HMP-PP), which are coupled to generate thiamin phosphate. Most organisms that can biosynthesize thiamin employ a kinase (HMPK or ThiD) to generate HMP-PP. In nearly all cases, this enzyme is bifunctional and can also salvage free HMP, producing HMP-P, the monophosphate precursor of HMP-PP. Here we present high-resolution crystal structures of an HMPK from Acinetobacter baumannii (AbHMPK), both unliganded and with pyridoxal 5-phosphate (PLP) noncovalently bound. Despite the similarity between HMPK and pyridoxal kinase enzymes, our kinetics analysis indicates that AbHMPK accepts HMP exclusively as a substrate and cannot turn over , , or nor does it display phosphatase activity. PLP does, however, act as a weak inhibitor of AbHMPK with an IC50 of 768 μM. Surprisingly, unlike other HMPKs, AbHMPK catalyzes only the phosphorylation of HMP and does not generate the diphosphate HMP-PP. This suggests that an additional kinase is present in A. baumannii, or an alternative mechanism is in operation to complete the biosynthesis of thiamin.

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Product Details of Pyridoxal HCl

CAS No. :65-22-5
Formula : C8H10ClNO3
M.W : 203.62
SMILES Code : O=CC1=C(CO)C=NC(C)=C1O.[H]Cl
Synonyms :
Pyridoxal (hydrochloride); Pyridoxal hydrochloride; HQ
MDL No. :MFCD00012809
InChI Key :FCHXJFJNDJXENQ-UHFFFAOYSA-N
Pubchem ID :6171

Safety of Pyridoxal HCl

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of Pyridoxal HCl

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 65-22-5 ]

[ 65-22-5 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 7504-94-1 ]
  • [ 65-22-5 ]
  • (E)-5-(hydroxymethyl)-2-methyl-4-((2-(pyrimidin-2-yl)hydrazono)methyl)pyridin-3-ol [ No CAS ]
YieldReaction ConditionsOperation in experiment
46% In ethanol; at 20℃; General procedure: The desired compounds 1a-g and 2a-f were prepared by reaction between pyridoxal hydrochloride (0.15 g, 0.74mmol) and the appropriate aromatic or heteroaromatic hydrazine or N-acylhydrazine (1.1 eq., 0.81mmol) in ethanol (10.0 mL). The reaction mixture was stirred for 1-48 hours at room temperature. After that, product was purified by wash-ing with cold ethanol (3.0 mL) and cold diethyl ether (3.0 mL), leading to the pure derivatives 1a-g and 2a-f as solid in 42-86% yields.
  • 2
  • [ 142-71-2 ]
  • [ 65-22-5 ]
  • [ 770-05-8 ]
  • 4Cu(2+)*4C(CH2O)CHNC(CH3)C(O)CCHNCH2CH(C6H4O)O(4-)*8H(1+)=Cu4(C(CH2O)CHNC(CH3)C(OH)CCHNCH2CH(C6H4OH)O)4 [ No CAS ]
 

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