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Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
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Chemical Structure| 289-95-2 Chemical Structure| 289-95-2
Chemical Structure| 289-95-2

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Pyrimidine is an endogenous metabolite, an important component of nucleic acid synthesis and metabolism, used in biochemical research.

4.5 *For Research Use Only !

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Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

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Product Details of Pyrimidine

CAS No. :289-95-2
Formula : C4H4N2
M.W : 80.09
SMILES Code : C1=NC=CC=N1
MDL No. :MFCD00006059
InChI Key :CZPWVGJYEJSRLH-UHFFFAOYSA-N
Pubchem ID :9260

Safety of Pyrimidine

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H225
Precautionary Statements:P210-P233-P240-P241-P242-P243-P280-P303+P361+P353-P370+P378-P403+P235-P501
Class:3
UN#:1993
Packing Group:

Application In Synthesis of Pyrimidine

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 289-95-2 ]

[ 289-95-2 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 16490-02-1 ]
  • [ 289-95-2 ]
  • 2
  • [ 16490-02-1 ]
  • [ 289-95-2 ]
  • [ 15719-64-9 ]
  • 3
  • [ 289-95-2 ]
  • [ 1193-24-4 ]
YieldReaction ConditionsOperation in experiment
With sodium methylate; triethylamine; malonic acid dimethyl ester; trichlorophosphate; at 60℃; for 0.5h; S1: 10 g of dimethyl malonate was dissolved in 300 ml of sodium methoxide solution, heated and stirred evenly, temperature of stirring is 60C, stirring time was 20min; S2: The catalyst was added to the solution, turn on condensate circulation to bring it to room temperature, stirred for 15min, the catalyst was a mixture of phosphorus oxychloride, triethylamine and pyrimidine, wherein phosphorus oxychloride: triethylamine: pyrimidine = 3:1:0.8; S3: Using a constant pressure dropping funnel, 60 ml of anhydrous triethylamine was slowly added dropwise, after completion of the dropwise addition, the temperature was raised, the dropwise addition of anhydrous triethylamine was completed within 15 minutes, followed by heating to 60 C.; S4: After completion of the reaction, the solvent was recovered by distillation under reduced pressure, the reaction solution was poured into a beaker containing ice water, sodium hydroxide was used to adjust the pH value of 6~7; S5: After suction filtration, the filtrate was extracted with dichloromethane, and the combined extracts were washed with water; S6: Dried over anhydrous magnesium sulfate, to give a solution of 4,6-dihydroxypyrimidine and the solvent in the solution using a rotary evaporator was distilled off to give 4,6-dihydroxypyrimidine.
 

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