Name: Pyrroloquinoline quinone disodium salt | PQQ disodium salt; Methoxatin disodium salt
Brand: Ambeed
SKU: A831583
Rating: 5.0 (120 reviews)

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CAS No. :	122628-50-6
Formula :	C₁₄H₄N₂Na₂O₈
M.W :	374.17
SMILES Code :	O=C(C1=NC2=C(C(NC(C(O)=O)=C3)=C3C(C2=O)=O)C(C([O-])=O)=C1)[O-].[Na+].[Na+]
Synonyms :	PQQ disodium salt; Methoxatin disodium salt
MDL No. :	MFCD00151711
InChI Key :	UFVBOGYDCJNLPM-UHFFFAOYSA-L
Pubchem ID :	3078772

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H315-H319-H335
Precautionary Statements:	P261-P305+P351+P338

HEI-OC1 auditory cells	0.1 nM or 1.0 nM	1 day	To investigate the protective effects of PQQ on the H2O2-induced premature senescence model in HEI-OC1 auditory cells and elucidate its mechanism of action. Results showed that PQQ pretreatment restored mitochondrial respiratory capacity, reduced mitochondrial potential decline, promoted mitochondrial fusion, and accelerated mitochondrial movement. Additionally, PQQ pretreatment significantly increased the protein expression of SIRT1 and PGC-1α and decreased PGC-1α acetylation.	NPJ Aging. 2022 Apr 19;8(1):3
SH-SY5Y cells	5 µM	12 hours	To evaluate the protective effect of PQQ against Aβ1-42-induced neurotoxicity. Results showed PQQ effectively reduced ROS production.	Adv Sci (Weinh). 2024 May;11(18):e2308970
L6 myotubes	0.5 µM	2 hours	To evaluate the effect of PQQ on lipid metabolism in insulin-resistant L6 myotubes, showing that short-term PQQ treatment decreased free fatty acids and triacylglycerols levels.	Int J Mol Sci. 2020 Nov 8;21(21):8382
Retinal cells	50 µM	2 hours	To assess the effect of PQQ on ATP content, results showed an increase in ATP levels	Acta Neuropathol Commun. 2023 Sep 8;11(1):146
Mouse brain cortical cells	0.1, 0.5, 1, 5, 10, 50 µM	2 hours	To assess the effect of PQQ on ATP content, results showed a significant increase in ATP levels	Acta Neuropathol Commun. 2023 Sep 8;11(1):146
Kupffer cells	10, 50 and 100 nM	2 hours	Simulated sepsis-induced acute liver injury, PQQ treatment alleviated inflammation, oxidative stress and apoptosis in LPS-induced Kupffer cells	Bioengineered. 2021 Dec;12(1):2459-2468
BV2 microglia cells	0.1, 1, 10 µM	2 hours pretreatment followed by 12 hours incubation	PQQ pretreatment significantly decreased rotenone-induced lactate dehydrogenase (LDH) release and suppressed the up-regulation of pro-inflammatory factors (IL-1β, IL-6, TNF-α) and NO release. Additionally, PQQ pretreatment increased the ratio of LC3-II/LC3-I and expression of Atg5, indicating enhanced autophagy.	Molecules. 2020 Sep 23;25(19):4359
L6 myotubes	0.5 µM	24 hours	To evaluate the effect of PQQ on lipid metabolism in insulin-resistant L6 myotubes, showing that long-term PQQ treatment increased diacylglycerols and triacylglycerols levels.	Int J Mol Sci. 2020 Nov 8;21(21):8382
SH-SY5Y cells	0.1, 1, 10 µM	24 hours	The conditioned medium (CM) from PQQ-pretreated BV2 cells significantly increased the viability of SH-SY5Y cells, indicating that PQQ protects neuronal cells from damage by inhibiting microglia-mediated inflammatory responses.	Molecules. 2020 Sep 23;25(19):4359
TM3 cells	100 nM	24 hours	To investigate the effect of PQQ on testosterone synthesis and cholesterol metabolism in PA-treated TM3 cells. Results showed that PQQ significantly increased intracellular cholesterol levels and testosterone synthesis, while reducing LDH release and PI uptake.	Cell Death Dis. 2023 Nov 7;14(11):723
KGN cells	20 µM	24 hours	To evaluate the effects of PQQ and MSC-Mito on mitochondrial function and oxidative stress in KGN cells. The results showed that the combined treatment significantly restored mitochondrial membrane potential and ATP production, reduced ROS and MDA levels, and increased SOD content.	Stem Cell Res Ther. 2024 Apr 5;15(1):97
Primary chicken hepatocytes	50, 100, 200 nM	24 hours	Improves lipid metabolism and hepatocyte tolerance to fatty degeneration and oxidative damage by enhancing mitochondrial biogenesis, thereby increasing anti-oxidative activity and anti-apoptosis capacity	Int J Mol Sci. 2021 Feb 1;22(3):1458
Human BM-MSCs	1, 5, 10, 20 µM	24 hours	To detect the effect of PQQ on the expression of Nrf2 and Keap1	Aging Cell. 2023 Sep;22(9):e13912
Primary cardiomyocytes	100 µM	24 hours	Evaluate the effect of PQQ on PE-induced cardiomyocyte hypertrophy, results showed PQQ significantly alleviated PE-induced hypertrophic activity	Front Pharmacol. 2022 Sep 27;13:977385
H9C2 cardiomyocytes	1-200 µM	24 hours	Evaluate the effect of PQQ on cell viability, results showed no cytotoxicity at 1-200 μM PQQ concentrations	Front Pharmacol. 2022 Sep 27;13:977385
HL-1 cardiomyocytes	1-200 µM	24 hours	Evaluate the effect of PQQ on cell viability, results showed no cytotoxicity at 1-200 μM PQQ concentrations	Front Pharmacol. 2022 Sep 27;13:977385
MLE-12 alveolar type II epithelial cells	40 µM	24 hours	To assess the effect of PQQ on PM2.5-induced cell migration capacity. Results showed that PQQ significantly attenuated the enhanced migratory ability induced by PM2.5.	J Cell Mol Med. 2024 Apr;28(8):e18299
MLE-12 alveolar type II epithelial cells	40 µM	24 hours	To investigate the inhibitory effect of PQQ on PM2.5-induced epithelial-mesenchymal transition (EMT). Results showed that PQQ reversed PM2.5-induced changes in cell morphology and reduced the expression of mesenchymal markers Vimentin and Snail.	J Cell Mol Med. 2024 Apr;28(8):e18299
MLE-12 alveolar type II epithelial cells	10, 20, 40 µM	24 hours	To evaluate the inhibitory effect of PQQ on PM2.5-induced upregulation of collagen expression. Results showed that PQQ significantly reduced COL1A1 protein expression in a dose- and time-dependent manner.	J Cell Mol Med. 2024 Apr;28(8):e18299
AC16 human myocardial cells	1 and 10 nM	24 hours	To investigate the protective effects of PQQ on AC16 cells under high glucose conditions. Results showed that 10 nmol/L PQQ significantly reduced high glucose-induced cell damage, inhibited NLRP3 inflammasome activation and NF-κB signaling pathway, decreased ROS production, and improved mitochondrial membrane potential.	Eur J Nutr. 2022 Jun;61(4):1823-1836
16-HBE cells	5-80 µM	24 or 48 hours	To examine the cytotoxicity of PQQ, results showed that PQQ reduced 16-HBE cell viability in a dose-dependent manner, but cell viability remained above 70% at 5-80 μM.	Mediators Inflamm. 2022 Oct 29;2022:1267841
H9c2 cells	1, 2.5, 5 µM	3 hours pretreatment followed by 24 hours exposure to Iso	To investigate the protective effects of PQQ against Iso-induced cardiac hypertrophy. Results showed that PQQ pretreatment significantly reduced Iso-induced cardiac hypertrophy, consistent with the results in AC16 cells.	Int J Mol Med. 2020 Mar;45(3):873-885
AC16 cells	1, 2.5, 5 µM	3 hours pretreatment followed by 24 hours exposure to Iso	To investigate the protective effects of PQQ against Iso-induced cardiac hypertrophy. Results showed that PQQ pretreatment significantly inhibited the expression of cardiac hypertrophy marker proteins, such as atrial natriuretic peptide, brain natriuretic peptide and β-myosin heavy chain, and inhibited the activation of the NF-κB signaling pathway.	Int J Mol Med. 2020 Mar;45(3):873-885
SH-SY5Y cells	100 µM	30 minutes	To investigate the protective effects of PQQ on rotenone-injured SH-SY5Y cells and its mechanisms. Results showed that PQQ promoted mitochondrial biogenesis via activation of the AMPK signaling pathway and alleviated rotenone-induced cell injury.	Acta Pharmacol Sin. 2021 May;42(5):665-678
Mouse brain microvascular endothelial bEND.3 cells	1, 10, 100 µM	48 or 72 hours	To investigate the protective effect of PQQ on high glucose-induced damage in bEND.3 cells. Results showed that PQQ significantly reversed high glucose-induced cell viability reduction, suppressed apoptosis and ROS production, and restored mitochondrial membrane potential and number.	Acta Pharmacol Sin. 2014 Nov;35(11):1402-10
CD4+ T cells	20-80 µM	5 days	To test the effect of PQQ on Th2 cell differentiation, results showed that PQQ significantly inhibited IL-4 and IL-5 production in a dose-dependent manner.	Mediators Inflamm. 2022 Oct 29;2022:1267841
IPEC-J2 cells	10 nM	6-hours pretreatment followed by 2-hours co-culture	To evaluate the protective effect of PQQ against H2O2-induced oxidative damage. Results showed that PQQ pretreatment significantly improved cell viability, increased the expression of tight junction proteins (ZO-1, ZO-2, Occludin, Claudin-1), reduced ROS and MDA levels, and upregulated nuclear Nrf2 and HO-1 protein expression.	J Anim Sci Biotechnol. 2021 Jun 18;12(1):77
Ram sperm	0 nM, 10 nM, 100 nM, 1000 nM, 10,000 nM	96 hours	To evaluate the effect of PQQ on chilled ram sperm quality, results showed that PQQ significantly improved sperm motility, membrane integrity, and acrosome integrity.	Antioxidants (Basel). 2024 Jan 15;13(1):104
Boar sperm	1000 nM	After freezing-thoursawing	Improved post-thaw sperm motility, viability, and acrosome integrity, reduced oxidative stress, and protected mitochondrial function.	Antioxidants (Basel). 2025 Jan 16;14(1):102

Laying hens	High-energy low-protein diet-induced metabolic dysfunction-associated fatty liver disease model	Dietary supplementation	0.08 and 0.16 mg/kg diet	Continued for 4 weeks	Significantly ameliorated liver biological functions, suppressed the progression of MAFLD mainly through enhanced lipid metabolism and protection of liver from oxidative injury	Int J Mol Sci. 2021 Feb 1;22(3):1458
Duroc × Landrace × Yorkshire crossbred pigs	Weaned piglet model	Oral (dietary supplementation)	0.15%, 0.30%, 0.45% PQQ·Na2	28 days	To investigate the effects of PQQ on growth performance, diarrhea incidence, and redox status in weaned pigs. Results showed that 0.45% PQQ significantly improved average daily gain (ADG) and gain-to-feed ratio (G:F), reduced diarrhea incidence and MDA content in liver and jejunum, and increased SOD activity in liver. 0.3% PQQ decreased ileal and liver MDA concentration, and 0.15% PQQ decreased ileal MDA concentration.	J Anim Sci Biotechnol. 2021 Jun 18;12(1):77
Laying hens	Laying hens performance model	Dietary supplementation	0.4 mg/kg	8 weeks	Increased the antioxidant ability of layers and eggs which might be in connection with the activation of the Nrf2/HO-1 pathway and optimized gut microflora	Food Chem X. 2023 Nov 30;20:101021
ICR mice	Rotenone-induced Parkinson’s disease model	Intraperitoneal injection	0.8, 4, 20 mg/kg/day	Once daily for 3 weeks	To investigate the neuroprotective effects of PQQ in a rotenone-induced Parkinson’s disease mouse model. Results showed that PQQ dose-dependently alleviated locomotor deficits and nigral dopaminergic neuron loss, and promoted mitochondrial biogenesis.	Acta Pharmacol Sin. 2021 May;42(5):665-678
SD rats	Sepsis model	Intraperitoneal injection	10 mg/kg	Administered 1 hour before surgery and continuously for 2 weeks post-surgery	PQQ treatment alleviated acute liver injury, inflammatory and oxidative stress damage and apoptosis of liver tissue cells in sepsis rats	Bioengineered. 2021 Dec;12(1):2459-2468
Balb/c mice	OVA-induced allergic airway inflammation model	Intraperitoneal injection	10 mg/kg or 20 mg/kg	Once daily for 11 days	To examine the effect of PQQ on allergic airway inflammation, results showed that PQQ significantly attenuated airway inflammation, reduced BALF inflammatory cell counts, altered the percentages of Th1, Th2, Th17, and Treg cells, and regulated the JAK-STAT signaling pathway.	Mediators Inflamm. 2022 Oct 29;2022:1267841
C57BL/6J mice	High-fat diet-induced obese mouse model	Intragastric administration	10 mg/kg/day	Once daily for 8 weeks	To investigate the effect of PQQ on lipid metabolism and testosterone synthesis in obese mice. Results showed that PQQ significantly improved abnormal lipid metabolism, increased testosterone levels, and improved testicular structure and sperm quality.	Cell Death Dis. 2023 Nov 7;14(11):723
C57BL/6 mice	Diabetic cardiomyopathy model	Oral	10, 20, or 40 mg/kg/day	Daily administration for 12 weeks	To investigate the protective effects of PQQ on diabetic cardiomyopathy. Results showed that PQQ significantly alleviated myocardial hypertrophy and fibrosis, enhanced antioxidant function, reduced inflammatory cytokine levels, and inhibited the NF-κB/NLRP3 inflammasome-mediated pyroptosis signaling pathway.	Eur J Nutr. 2022 Jun;61(4):1823-1836
C57BL/6J mice	Chemotherapy-induced premature ovarian insufficiency model	Oral	15 mg/kg PQQ	Once daily for three weeks	To evaluate the therapeutic effects of PQQ and MSC-Mito on ovarian function in POI mice. The results showed that the combined treatment significantly restored body weight, ovarian volume and relative weight, improved the estrous cycle, increased the number of follicles at various stages, reduced atretic follicles, and restored sex hormone secretion and antioxidant capacity.	Stem Cell Res Ther. 2024 Apr 5;15(1):97
Mice	Retinal axotomy explant model and Rotenone-induced retinal degeneration model	Intraperitoneal injection	20 mg/kg	Single injection or every 48 hours for 2 weeks	To evaluate the neuroprotective effect of PQQ on retinal ganglion cells, results showed PQQ was neuroprotective in both models	Acta Neuropathol Commun. 2023 Sep 8;11(1):146
C57/BL6 mice	Aβ1-42-induced Alzheimer's disease mouse model	Intragastric administration	20 mg/kg	Once daily for 14 days	To evaluate the effect of PQQ on cognitive dysfunction. Results showed PQQ significantly improved short-term memory and spatial learning in AD mice.	Adv Sci (Weinh). 2024 May;11(18):e2308970
Sprague-Dawley rats	Oral toxicokinetic study	Oral	250 mg/kg, 500 mg/kg, 1000 mg/kg	Single dose and 28-day repeated administration	Study the toxicokinetic properties and safety evaluation of PQQ disodium salt	Molecules. 2022 Nov 17;27(22):7947
Duroc × Landrace × Yorkshire crossbred piglets	Enterotoxigenic Escherichia coli K88 infection model	Dietary supplementation	3 mg/kg	14 days	To evaluate the effect of PQQ on gut inflammation and microbiota dysbiosis induced by ETEC K88. Results showed that PQQ supplementation significantly alleviated ETEC K88-induced jejunal mucosal barrier function damage and regulated colonic microbiota.	Front Microbiol. 2020 Jul 24;11:1754
Weaned piglets	LPS-induced intestinal inflammation model	Oral	3.0 mg/kg	14 days	Alleviated intestinal inflammation and cell apoptosis, improved intestinal barrier function via the MKK3/6-P38 pathway	Int J Mol Sci. 2024 Sep 8;25(17):9723
Pigs	Weaned piglets	Dietary supplementation	3.0 mg/kg	28 days	To compare the effects of pyrroloquinoline quinone (PQQ) and zinc oxide (ZnO) on growth performance, diarrhea indices, nutrient digestibility, antioxidant capacity, neurotransmitter levels, and metabolism in weaned pigs. Results showed that both PQQ and ZnO improved growth performance, nutrient digestibility, antioxidant capacity, and regulated neurotransmitter levels in weaned pigs.	Anim Nutr. 2023 Oct 4;15:409-419
C57BL/6 mice	Ovariectomy (OVX)-induced osteoporosis model	Dietary supplementation	4 mg/kg	Daily for 8 weeks	To evaluate the protective effect of PQQ on ovariectomy-induced osteoporosis. Results showed that PQQ supplementation could prevent OVX-induced bone loss and improve bone strength by inhibiting oxidative stress and osteocyte senescence.	Int J Biol Sci. 2019 Jan 1;15(1):58-68
Mice	Natural aging-induced osteoporosis model	Dietary supplementation	4 mg/kg diet	Starting from 6 or 12 months of age, lasting for 12 or 6 months	To evaluate the preventive effect of PQQ supplementation on natural aging-induced osteoporosis	Aging Cell. 2023 Sep;22(9):e13912
C57BL/6 male mice	Iso-induced cardiac hypertrophy model	Intraperitoneal injection	40 mg/kg	Once every 4 days for approximately 5 weeks	To investigate the protective effects of PQQ against Iso-induced cardiac hypertrophy. Results showed that PQQ pretreatment significantly reduced the increase in myocardial cell surface area induced by Iso and decreased the heart weight/body weight ratio.	Int J Mol Med. 2020 Mar;45(3):873-885
C57BL/6 mice	Transverse aortic constriction (TAC)-induced myocardial hypertrophy model	Gavage	40 mg/kg	Every other day for 6 weeks	Evaluate the effect of PQQ on TAC-induced myocardial hypertrophy and fibrosis, results showed PQQ significantly suppressed myocardial hypertrophy and fibrosis, and inhibited ferroptotic death of hypertrophic myocardial cells	Front Pharmacol. 2022 Sep 27;13:977385
C57BL/6J mice	PM2.5-induced pulmonary fibrosis model	Intraperitoneal injection	5 mg/kg	Twice a week for 12 weeks	To evaluate the protective effect of PQQ against PM2.5-induced pulmonary fibrosis. Results showed that PQQ significantly reduced collagen deposition, improved pulmonary function, and decreased the expression of EMT markers COL1A1, Vimentin, Snail, and TGF-β.	J Cell Mol Med. 2024 Apr;28(8):e18299

Bio Calculators
Preparing Stock Solutions		1mg	5mg	10mg
Preparing Stock Solutions	1 mM 5 mM 10 mM	2.67mL 0.53mL 0.27mL	13.36mL 2.67mL 1.34mL	26.73mL 5.35mL 2.67mL
Dissolving Methods	Animal experiment The prepared working fluid is recommended to be prepared now and used up as soon as possible in a short period of time. The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound. Protocol 1

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

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CAS No.: 122628-50-6

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CAS No.: 122628-50-6

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