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Chemical Structure| 902688-24-8 Chemical Structure| 902688-24-8

Structure of Qstatin
CAS No.: 902688-24-8

Chemical Structure| 902688-24-8

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Qstatin is a potent and selective inhibitor of Vibrio quorum sensing (QS). SmcR is the LuxR homologue in V. vulnificus.

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Product Details of Qstatin

CAS No. :902688-24-8
Formula : C7H5BrN2O2S2
M.W : 293.16
SMILES Code : O=S(N1N=CC=C1)(C2=CC=C(Br)S2)=O
MDL No. :MFCD05117319
InChI Key :MLRBBGFHILYDBK-UHFFFAOYSA-N
Pubchem ID :3237735

Safety of Qstatin

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P280-P301+P312-P302+P352-P305+P351+P338

Isoform Comparison

Biological Activity

In Vitro:

Cell Line
Concentration Treated Time Description References
Vibrio parahaemolyticus 500 µM 24 h QStatin affected the colony opacity of V. parahaemolyticus, indicating its inhibition of OpaR activity. PMC5790914
Vibrio harveyi 20 µM QStatin significantly inhibited the bioluminescence of V. harveyi, indicating its inhibition of LuxR activity. PMC5790914
Vibrio vulnificus 20 µM QStatin significantly inhibited the luminescence reporter gene expression in V. vulnificus WT, indicating its inhibition of SmcR activity. PMC5790914

In Vivo:

Species
Animal Model
Administration Dosage Frequency Description References
Artemia franciscana Artemia franciscana Aqueous solution 20 µM 60 hours QStatin significantly increased the survival rate of nauplii challenged with V. vulnificus, V. harveyi, and V. parahaemolyticus, indicating its attenuation of bacterial virulence through QS inhibition. PMC5790914

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3.41mL

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