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Chemical Structure| 64302-87-0 Chemical Structure| 64302-87-0

Structure of R162
CAS No.: 64302-87-0

Chemical Structure| 64302-87-0

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R162 is a potent inhibitor of glutamate dehydrogenase 1 (GDH1/GLUD1) and represses glioma cell growth.

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Product Details of R162

CAS No. :64302-87-0
Formula : C17H12O3
M.W : 264.28
SMILES Code : OC1=C2C(=O)C3=C(C=CC=C3)C(=O)C2=CC=C1CC=C
MDL No. :MFCD00666806
InChI Key :IMUBGIOLZQTIGI-UHFFFAOYSA-N
Pubchem ID :4412951

Safety of R162

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319
Precautionary Statements:P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313

Related Pathways of R162

GPCR

Isoform Comparison

Biological Activity

In Vitro:

Cell Line
Concentration Treated Time Description References
4T1 cells 1 µg/mL 4 hours Evaluate cellular uptake and cytotoxicity of MLipRIR NPs, showing effective internalization and significant cell death. Theranostics. 2021 Sep 13;11(19):9470-9491

In Vivo:

Species
Animal Model
Administration Dosage Frequency Description References
BALB/c mice 4T1 tumor model Intravenous injection 0.5 mg/kg Administered on days 0, 2, and 6, lasting for 14 days Evaluate tumor suppression effect of MLipRIR NPs, showing significant tumor growth inhibition and immunogenic cell death. Theranostics. 2021 Sep 13;11(19):9470-9491
Nude mice H1299 xenograft model Intraperitoneal injection 20 mg/kg/day Once daily for 35 days R162 significantly inhibited tumor growth and mass Cancer Cell. 2015 Feb 9;27(2):257-70
Human patients Cardiac surgery patients in ICU Through hospital water supply Approximately 10 mg/L hydrogen peroxide 4 to 6 days per month, 6 to 8 hours each time To evaluate the relationship between hospital water disinfection procedure and methemoglobinemia. Results showed that on disinfection days, the methemoglobin fraction significantly increased to 5.9% (median), with a maximum of 12.2%, compared to 1.0% on disinfection-free days. Crit Care. 2009;13(5):R162

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.78mL

0.76mL

0.38mL

18.92mL

3.78mL

1.89mL

37.84mL

7.57mL

3.78mL

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