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CAS No. :	89412-79-3
Formula :	C₄₇H₇₆O₁₆
M.W :	897.10
SMILES Code :	O=C([C@]12CCC(C)(C)C[C@@]1([H])C3=CC[C@]4([H])[C@@]5(C)CC[C@H](O[C@H]6[C@H](O[C@H]7[C@H](O[C@H]8[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O8)[C@@H](O)[C@H](O)[C@@H](CO)O7)[C@@H](O)[C@@H](O)CO6)C(C)(C)[C@]5([H])CC[C@@]4(C)[C@]3(C)CC2)O
Synonyms :	NSC382873; Raddeanin R3
MDL No. :	MFCD10566637

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302
Precautionary Statements:	P264-P270-P301+P312-P330-P501

HIBEpiC	0-160 μg/mL	24 hours	RA showed lower toxicity to normal cells	World J Gastroenterol. 2019 Jul 14;25(26):3380-3391
RAW264.7 cells	0.8 µM	0, 10, 30 minutes	RA significantly inhibited RANKL-induced phosphorylation of AKT.	Cell Death Dis. 2018 Mar 7;9(3):376
SNU-1 cells	0, 2, 4, 8, 16 µM	12 hours	RA effectively inhibited the proliferation of SNU-1 cells, with the inhibition rate rising to 86.26%±1.58% when the RA concentration reached 16 μM.	J Tradit Complement Med. 2024 Jul 20;15(2):161-169
HGC-27 cells	0, 2, 4, 8, 16 µM	12 hours	RA effectively inhibited the proliferation of HGC-27 cells, with the inhibition rate rising to 88.19%±0.34% when the RA concentration reached 16 μM.	J Tradit Complement Med. 2024 Jul 20;15(2):161-169
22Rv1 cells	3 µM	12 hours	To investigate the effect of RA on AR-V transcriptional activity, results showed that RA inhibited AR-V transactivating activity.	J Cell Mol Med. 2019 May;23(5):3656-3664
B16-OVA cells	5 µM	20 hours	RA significantly increased LacZ activity and IL-2, IFN-γ secretion, promoted DC maturation and CD8+ T cell activation	Adv Sci (Weinh). 2023 May;10(13):e2206737
MC38 cells	5 µM	20 hours	RA significantly increased HMGB1-Gluc activity and ATP release, upregulated CRT surface expression	Adv Sci (Weinh). 2023 May;10(13):e2206737
B16 cells	5 µM	20 hours	RA significantly increased HMGB1-Gluc activity and ATP release, upregulated CRT surface expression	Adv Sci (Weinh). 2023 May;10(13):e2206737
U251 cells	50 nM and 100 nM	24 hours	RA significantly inhibited the proliferation, migration, and invasion of U251 cells, and downregulated the expression of Skp2 and EMT-related proteins	J Cancer. 2025 Jan 1;16(1):44-54
U87 cells	50 nM and 100 nM	24 hours	RA significantly inhibited the proliferation, migration, and invasion of U87 cells, and downregulated the expression of Skp2 and EMT-related proteins	J Cancer. 2025 Jan 1;16(1):44-54
MDA-MB-231 cells	6.25, 12.5 µM	24 hours	RA significantly reduced proliferation and invasion of MDA-MB-231 cells.	Cell Death Dis. 2018 Mar 7;9(3):376
U251	0-800 nM	24 hours	RA inhibited the viability of GBM cell lines in a dose-dependent manner	Int J Med Sci. 2021 Feb 4;18(7):1609-1617
U87	0-800 nM	24 hours	RA inhibited the viability of GBM cell lines in a dose-dependent manner	Int J Med Sci. 2021 Feb 4;18(7):1609-1617
LN299	0-800 nM	24 hours	RA inhibited the viability of GBM cell lines in a dose-dependent manner	Int J Med Sci. 2021 Feb 4;18(7):1609-1617
T98G	0-800 nM	24 hours	RA inhibited the viability of GBM cell lines in a dose-dependent manner	Int J Med Sci. 2021 Feb 4;18(7):1609-1617
MDA-MB-231	2–8 µM	24 hours	RA dose-dependently enhanced autophagy, as evidenced by increased LC3 levels.	Acta Pharmacol Sin. 2018 Apr;39(4):642-648
MCF-7	2–8 µM	24 hours	RA dose-dependently enhanced autophagy, as evidenced by increased LC3 levels.	Acta Pharmacol Sin. 2018 Apr;39(4):642-648
T47D	2–8 µM	24 hours	RA dose-dependently enhanced autophagy, as evidenced by increased LC3 levels.	Acta Pharmacol Sin. 2018 Apr;39(4):642-648
H1975	0, 1, 2, 4 µM	24 hours	Raddeanin A inhibits NSCLC cell survival, inhibits invasion and migration and causes cell cycle arrest in G1 phase.	Transl Oncol. 2025 Jun;56:102382
HCC827	0, 1, 2, 4 µM	24 hours	Raddeanin A inhibits NSCLC cell survival, inhibits invasion and migration and causes cell cycle arrest in G1 phase.	Transl Oncol. 2025 Jun;56:102382
PC-9	0, 1, 2, 4 µM	24 hours	Raddeanin A inhibits NSCLC cell survival, inhibits invasion and migration and causes cell cycle arrest in G1 phase.	Transl Oncol. 2025 Jun;56:102382
A549	0, 1, 2, 4 µM	24 hours	Raddeanin A inhibits NSCLC cell survival, inhibits invasion and migration and causes cell cycle arrest in G1 phase.	Transl Oncol. 2025 Jun;56:102382
H1299	0, 1, 2, 4 µM	24 hours	Raddeanin A inhibits NSCLC cell survival, inhibits invasion and migration and causes cell cycle arrest in G1 phase.	Transl Oncol. 2025 Jun;56:102382
Human osteosarcoma cells SJSA	2 µM	24 hours	RA inhibited cell proliferation and induced apoptosis via ROS generation, which could be partially rescued by GSH pretreatment.	Cancer Sci. 2019 May;110(5):1746-1759.
Human osteosarcoma cells 143B	2 µM	24 hours	RA inhibited cell proliferation and induced apoptosis via ROS generation, which could be partially rescued by GSH pretreatment.	Cancer Sci. 2019 May;110(5):1746-1759.
JEG-3/VP16	8 µM	24 hours	RA significantly suppressed STAT3 activation and NFIL3 protein expression in a dose-dependent manner and induced Caspase 3-dependent apoptosis.	J Cell Physiol. 2018 Jul;233(7):5370-5382
JEG-3/5-FU	8 µM	24 hours	RA significantly suppressed STAT3 activation and NFIL3 protein expression in a dose-dependent manner and induced Caspase 3-dependent apoptosis.	J Cell Physiol. 2018 Jul;233(7):5370-5382
JEG-3/MTX	8 µM	24 hours	RA significantly suppressed STAT3 activation and NFIL3 protein expression in a dose-dependent manner and induced Caspase 3-dependent apoptosis.	J Cell Physiol. 2018 Jul;233(7):5370-5382
NPC-039 cells	0.25, 0.5, 1 µM	24 hours	Evaluate the effect of Raddeanin A on the apoptosis of NPC-039 cells. The results showed that Raddeanin A induced apoptosis in NPC-039 cells through both caspase-dependent and independent pathways.	J Cell Mol Med. 2024 Aug;28(16):e70016
FaDu cells	0.25, 0.5, 1 µM	24 hours	Evaluate the effect of Raddeanin A on the apoptosis of FaDu cells. The results showed that Raddeanin A induced apoptosis in FaDu cells through both caspase-dependent and independent pathways.	J Cell Mol Med. 2024 Aug;28(16):e70016
K562 cells	0.25, 0.5, 1 µM	24 hours	Evaluate the effect of Raddeanin A on the apoptosis of K562 cells. The results showed that Raddeanin A induced apoptosis in K562 cells through both caspase-dependent and independent pathways.	J Cell Mol Med. 2024 Aug;28(16):e70016
22Rv1 cells	0-6 µM	24 hours	To assess the effect of RA on the growth of CRPC cells, results showed that RA inhibited the growth of all AR-positive cells in a dose- and/or time-dependent manner.	J Cell Mol Med. 2019 May;23(5):3656-3664
LICCF	0-160 μg/mL	24 hours	RA reduced cell viability in a dose-dependent pattern	World J Gastroenterol. 2019 Jul 14;25(26):3380-3391
LIPF178C	0-160 μg/mL	24 hours	RA reduced cell viability in a dose-dependent pattern	World J Gastroenterol. 2019 Jul 14;25(26):3380-3391
LIPF155C	0-160 μg/mL	24 hours	RA reduced cell viability in a dose-dependent pattern	World J Gastroenterol. 2019 Jul 14;25(26):3380-3391
RBE	0-160 μg/mL	24 hours	RA reduced cell viability in a dose-dependent pattern	World J Gastroenterol. 2019 Jul 14;25(26):3380-3391
C-33A cells	0, 1, 2, 4, 6, 8 µM	24 hours and 48 hours	RA significantly reduced the viability of c-33A cells and inhibited their invasion and migration abilities.	Aging (Albany NY). 2021 Feb 17;13(5):7166-7179
Hela cells	0, 1, 2, 4, 6, 8 µM	24 hours and 48 hours	RA significantly reduced the viability of Hela cells and inhibited their invasion and migration abilities.	Aging (Albany NY). 2021 Feb 17;13(5):7166-7179
RPMI 8226 cells	6.091 µM (24 hours), 3.438 µM (48 hours)	24 hours, 48 hours	To evaluate the inhibitory effect of RA on the proliferation of RPMI 8226 cells, results showed that RA inhibited cell proliferation in a time- and concentration-dependent manner	Sci Rep. 2024 Nov 23;14(1):29061
MM.1R cells	3.905 µM (24 hours), 2.18 µM (48 hours)	24 hours, 48 hours	To evaluate the inhibitory effect of RA on the proliferation of MM.1R cells, results showed that RA inhibited cell proliferation in a time- and concentration-dependent manner	Sci Rep. 2024 Nov 23;14(1):29061
MM.1S cells	1.616 µM (24 hours), 1.058 µM (48 hours)	24 hours, 48 hours	To evaluate the inhibitory effect of RA on the proliferation of MM.1S cells, results showed that RA inhibited cell proliferation in a time- and concentration-dependent manner	Sci Rep. 2024 Nov 23;14(1):29061
MG63	3.977 ± 0.055 µM (IC50)	48 hours	RA inhibited cell proliferation and colony formation and induced apoptotic cell death in a dose-dependent manner	Int J Biol Sci. 2019 Jan 24;15(3):668-679
U2OSR	6.510 ± 0.062 µM (IC50)	48 hours	RA inhibited cell proliferation and colony formation and induced apoptotic cell death in a dose-dependent manner	Int J Biol Sci. 2019 Jan 24;15(3):668-679
U2OS	3.527 ± 0.018 µM (IC50)	48 hours	RA inhibited cell proliferation and colony formation and induced apoptotic cell death in a dose-dependent manner	Int J Biol Sci. 2019 Jan 24;15(3):668-679
KHOSR	2.053 ± 0.086 µM (IC50)	48 hours	RA inhibited cell proliferation and colony formation and induced apoptotic cell death in a dose-dependent manner	Int J Biol Sci. 2019 Jan 24;15(3):668-679
HOS	1.512 ± 0.034 µM (IC50)	48 hours	RA inhibited cell proliferation and colony formation and induced apoptotic cell death in a dose-dependent manner	Int J Biol Sci. 2019 Jan 24;15(3):668-679
GSCs (glioblastoma stem cells)	50 nM and 100 nM	5 days	RA significantly inhibited the sphere-forming ability of GSCs and downregulated the expression of Skp2 and stemness markers (Sox2, Nestin)	J Cancer. 2025 Jan 1;16(1):44-54
Bone marrow-derived macrophages (BMMs)	0, 0.2, 0.4, 0.8 µM	7 days	RA inhibited RANKL-induced formation of TRAP-positive multinucleated osteoclasts in a concentration-dependent manner.	Cell Death Dis. 2018 Mar 7;9(3):376
KHYG-1 cells	0.25, 0.5, 1 µM	72 hours	Evaluate the effect of Raddeanin A on the proliferation of KHYG-1 cells. The results showed that Raddeanin A treatment significantly increased the cytotoxicity of KHYG-1 cells against K562 cells and increased IFN-γ secretion.	J Cell Mol Med. 2024 Aug;28(16):e70016
C4-2 cells	3 µM	9 hours	To investigate the effect of RA on AR transcriptional activity, results showed that RA inhibited AR-FL transactivating activity.	J Cell Mol Med. 2019 May;23(5):3656-3664
Human osteosarcoma cell SJSA	2 μM	24 h	RA inhibited cell proliferation and induced apoptosis through ROS generation	Cancer Sci. 2019 May;110(5):1746-1759.
Human osteosarcoma cell 143B	2 μM	24 h	RA inhibited cell proliferation and induced apoptosis through ROS generation	Cancer Sci. 2019 May;110(5):1746-1759.

BALB/c nude mice	Nude mouse xenograft tumor model	Intraperitoneal injection	0.5 mg/kg, 1.0 mg/kg	Once every 2 days for 7 times over 30 days	Raddeanin A also demonstrated an inhibitory effect on NSCLC tumor growth in a nude mouse xenograft tumor model.	Transl Oncol. 2025 Jun;56:102382
C57BL/6 mice	MC38 tumor model	Intraperitoneal or intratumoral injection	1, 2, 4 mg/kg	Four injections over 16 days	RA significantly inhibited tumor growth and increased tumor-infiltrating CD8+ T cells and CD103+CD11c+ DCs	Adv Sci (Weinh). 2023 May;10(13):e2206737
BALB/c nude mice	Intracranial U87 xenograft model	Intraperitoneal injection	100 mg/kg/day	Once daily during the experiment	RA inhibited tumor growth, prolonged survival time, downregulated the expression of β-catenin, EMT markers and VEGF, and decreased vessel density in vivo	Int J Med Sci. 2021 Feb 4;18(7):1609-1617
BALB/c nude mice	U87 subcutaneous xenograft model and intracranial xenograft model	Intraperitoneal injection	100 mg/kg/day (subcutaneous model) and 200 mg/kg/day (intracranial model)	Once daily for 20 days	RA significantly inhibited the growth of U87 xenografts and downregulated the expression of Skp2, EMT markers, and stemness markers	J Cancer. 2025 Jan 1;16(1):44-54
BALB/c nude mice	SNU-1 xenograft tumor model	Intraperitoneal injection	2 mg/kg, 4 mg/kg, 6 mg/kg	Every other day for 35 days	Both RA and PTX showed significant anti-tumor effects, but the combination of low-dose RA with PTX did not further enhance the anti-tumor effect. Neither RA nor paclitaxel significantly damaged the liver of tumor-bearing nude mice, and the combined use of RA and PTX did not increase the risk of liver injury.	J Tradit Complement Med. 2024 Jul 20;15(2):161-169
BALB/c nude mice	KHOSR tibia orthotopic tumor model	Intraperitoneal injection	5 mg/kg	Every 3 days for 7-10 treatments	RA suppressed in vivo tumor growth and induced apoptosis	Int J Biol Sci. 2019 Jan 24;15(3):668-679
BALB/c nude mice	Orthotopic tibial osteosarcoma model	Intraperitoneal injection	5 mg/kg and 10 mg/kg	Every 3 days for 8 doses	RA significantly inhibited tumor growth and induced apoptosis, with a 58% reduction in tumor weight at 10 mg/kg dose.	Cancer Sci. 2019 May;110(5):1746-1759.
C57BL/6 mice	Acute intracerebral hemorrhage model	Intraperitoneal injection	50 mg/kg and 100 mg/kg	Single dose 15 minutes after ICH induction	RA significantly improved neurological behavioral scores in ICH mice, reduced the volume of intracerebral hematoma and cerebral edema, and reduced microglial infiltration around hemorrhagic lesions	Int J Med Sci. 2022 Jul 11;19(8):1235-1240
C57BL/6 mice	Ti-particle-induced calvarial osteolysis model	Intraperitoneal injection	50 or 100 µg/kg/day	Once daily for 14 days	RA significantly reduced Ti-particle-induced osteolysis.	Cell Death Dis. 2018 Mar 7;9(3):376
BALB/c athymic nude mice	Tibial orthotopic osteosarcoma model	Intraperitoneal injection	5 mg/kg and 10 mg/kg	Every 3 days for 8 doses	RA significantly inhibited tumor growth and induced apoptosis	Cancer Sci. 2019 May;110(5):1746-1759.

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CAS No.: 89412-79-3

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CAS No.: 89412-79-3

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Precautionary Statements-General

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Preparing Stock Solutions		1mg	5mg	10mg
Preparing Stock Solutions	1 mM 5 mM 10 mM	1.11mL 0.22mL 0.11mL	5.57mL 1.11mL 0.56mL	11.15mL 2.23mL 1.11mL
Dissolving Methods	Animal experiment Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn: in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day; The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound. Protocol 1 Protocol 2

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed