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CAS No. :	1887095-82-0
Formula :	C₉₁H₁₃₈N₁₂O₂₄
M.W :	1784.14
SMILES Code :	NC1=C2C(C3=CC=C4OC(N)=NC4=C3)=NN(CCCCNC(CCOCCOCCOCCOCCOCCOCCOCCOCCN5N=NC(COCCO[C@@H]6CC[C@@H](C[C@@H](C)[C@@]7(CC([C@H](C)/C=C(C)/[C@@H](O)[C@@H](OC)C([C@H](C)C[C@H](C)/C=C/C=C\C=C(C)\[C@@H](OC)C[C@@]8(CC[C@@H](C)[C@@](C(C(N9CCCC[C@]9(C(O7)=O)[H])=O)=O)(O)O8)[H])=O)=O)[H])C[C@H]6OC)=C5)=O)C2=NC=N1
MDL No. :	MFCD32633594

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H315-H319-H335
Precautionary Statements:	P261-P305+P351+P338

K562 cells	3 nM	24 hours	Evaluate the effect of IFITM expression on the intracellular activity of RapaLink-1, results show that IFITM expression promotes the intracellular activity of RapaLink-1	Science. 2022 Dec 9;378(6624):1097-1104
Beta-TC-6 cells	10 nM	24 hours	To investigate the effects of RapaLink-1 on amino acid metabolism and mitochondrial functions. Results showed that RapaLink-1 significantly decreased L-aspartate, L-asparagine, L-glutamate, and glycine levels, and reduced ATP production and non-mitochondrial oxygen consumption.	Nutrients. 2022 Jul 22;14(15):3022
PC3 cells	0.3 nM	24 hours	Chronic low-dose RapaLink1 treatment substantially inhibited mTORC1 activity without affecting mTORC2 activity.	Sci Signal. 2021 Sep 21;14(701):eabe0161
Non-cancerous neural stem cells (iNSC)	15.5 nM (IC50)	4 days	RL1 showed weaker inhibitory effects on non-cancerous neural stem cells, indicating selectivity for cancer cells.	Cancers (Basel). 2020 Dec 21;12(12):3859
Glioblastoma stem cells (GSCs)	1.5, 6, 12, 24, 48 nM	4 days	RL1 significantly inhibited cell growth, proliferation, migration, and clonogenic potential of GSCs, and reduced the expression of stem cell markers (CD133, SOX2) and EMT markers (CD44, ZEB1).	Cancers (Basel). 2020 Dec 21;12(12):3859
3T3-L1 adipocytes	3 nM, 10 nM and 20 nM	4 hours	High-dose RapaLink1 substantially inhibited insulin-induced glucose uptake, indicating a major role for mTORC2, but not mTORC1, in acute insulin-regulated glucose uptake.	Sci Signal. 2021 Sep 21;14(701):eabe0161
MCF7 cells	10 nM	4 hours	To monitor mTOR signaling by western blot, results showed that RapaLink-1 significantly reduced the levels of phospho-S6 and phospho-4EBP, while the addition of FK506 completely blocked this effect	Nature. 2022 Sep;609(7928):822-828
HEK-293E cells	3 nM	4 hours	Selectively and almost completely blocked mTORC1 activity toward both rapamycin-sensitive and rapamycin-resistant sites without any demonstrable effect on mTORC2 targets.	Sci Signal. 2021 Sep 21;14(701):eabe0161
SU-DHL-6	12.5 nM and 50 nM	48 hours	Evaluate the sensitivity of RapaLink-1 in EZH2 wild-type and mutant lymphoma cells	Sci Transl Med. 2017 Jun 28;9(396):eaak9969
SU-DHL-4	12.5 nM and 50 nM	48 hours	Evaluate the sensitivity of RapaLink-1 in EZH2 wild-type and mutant lymphoma cells	Sci Transl Med. 2017 Jun 28;9(396):eaak9969
SU-DHL-10	12.5 nM and 50 nM	48 hours	Evaluate the sensitivity of RapaLink-1 in EZH2 wild-type and mutant lymphoma cells	Sci Transl Med. 2017 Jun 28;9(396):eaak9969
DoHH2	12.5 nM and 50 nM	48 hours	Evaluate the sensitivity of RapaLink-1 in EZH2 wild-type and mutant lymphoma cells	Sci Transl Med. 2017 Jun 28;9(396):eaak9969
Toledo	12.5 nM and 50 nM	48 hours	Evaluate the sensitivity of RapaLink-1 in EZH2 wild-type and mutant lymphoma cells	Sci Transl Med. 2017 Jun 28;9(396):eaak9969
OCI-LY19	12.5 nM and 50 nM	48 hours	Evaluate the sensitivity of RapaLink-1 in EZH2 wild-type and mutant lymphoma cells	Sci Transl Med. 2017 Jun 28;9(396):eaak9969
Normal human lung fibroblasts (NHLFs)	2 nM	48 hours	RapaLink-1 completely inhibited TGF-β-induced ATF4 accumulation and metabolic reprogramming, including increases in glycolysis and mitochondrial oxygen consumption.	Am J Respir Cell Mol Biol. 2020 Nov;63(5):601-612
BM18 PDX organoids	0.0003 µM (IC50)	48 hours	To evaluate the cytotoxic effect of RapaLink-1 on BM18 PDX organoids, results showed that RapaLink-1 significantly reduced organoid viability.	Front Oncol. 2020 Jun 23;10:1012
LAPC9 PDX organoids	0.0046 µM (IC50)	48 hours	To evaluate the cytotoxic effect of RapaLink-1 on LAPC9 PDX organoids, results showed that RapaLink-1 significantly reduced organoid viability.	Front Oncol. 2020 Jun 23;10:1012
HeLa cells	1 nM and 3 nM	48 hours	RapaLink1 significantly inhibited cell proliferation, showing better efficacy than rapamycin.	Sci Signal. 2021 Sep 21;14(701):eabe0161
HMLER cells	5 nM	6 days	Inhibition of mTOR signaling, reduction of CD24lowCD44high stem cell population and mammosphere formation	Sci Signal. 2019 Feb 26;12(570):eaau8544
K562 cells	10 nM	72 hours	To evaluate the effect of RapaLink-1 on cell proliferation, results showed that CRISPRi-mediated knockdown of FKBP12 gene significantly impeded the cellular activity of RapaLink-1	Nature. 2022 Sep;609(7928):822-828

Male mice	Alcohol Use Disorder model	Intraperitoneal injection	1 mg/kg	Three times a week for 4 weeks	RapaLink-1 blocked mTORC1 activation in the liver, while RapaBlock protected mTORC1 activity in the periphery. Co-administration of RapaLink-1 and RapaBlock inhibited alcohol-dependent mTORC1 activation in the nucleus accumbens and attenuated alcohol seeking and drinking.	Nat Commun. 2021 Jul 27;12(1):4407
BALB/cnu/nu mice	Glioblastoma xenograft model	Intraperitoneal injection	1 mg/kg RapaLink-1 and 40 mg/kg RapaBlock	Every 5 days for 25-30 days	To evaluate the therapeutic effect of the combination of RapaLink-1 and RapaBlock, results showed that the combination significantly suppressed tumor growth and improved survival without detectable systemic toxicity	Nature. 2022 Sep;609(7928):822-828
NSG mice	Orthotopic mammary fat pad implantation model	Intraperitoneal injection	1.5 mg/kg	Every 5 days for 20 days, then once a week for 2 weeks	RapaLink-1 almost completely inhibited tumor formation	Sci Signal. 2019 Feb 26;12(570):eaau8544
CB17/SCID mice	LAPC9 PDX model	Intraperitoneal injection	1.5 mg/kg	Every 5-7 days, during the experiment period	To evaluate the anti-tumor effect of RapaLink-1 in vivo on LAPC9 PDX model, results showed that RapaLink-1 significantly delayed tumor growth.	Front Oncol. 2020 Jun 23;10:1012
Rats	Middle cerebral artery occlusion (MCAO) model	Intraperitoneal injection	2 mg/kg	Single dose, 10 minutes after MCAO	To investigate the effects of Rapalink-1 on neuronal survival and BBB disruption in the early stage of cerebral ischemia–reperfusion. Results showed that Rapalink-1 increased infarct size and BBB disruption.	Front Physiol. 2021 Jul 20;12:706528
Drosophila melanogaster	Adult flies	Food supplemented	6 μM	For three days	In contrast to rapamycin, RapaLink1 significantly shortened fly survival under starvation conditions.	Sci Signal. 2021 Sep 21;14(701):eabe0161

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CAS No.: 1887095-82-0

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CAS No.: 1887095-82-0

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Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed