Structure of Rapastinel
CAS No.: 117928-94-6
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The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
Rapastinel is a putative NMDAR functional glycine-site partial agonist.
Synonyms: GLYX-13; BV-102; TPPT-amide
4.5
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Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
CAS No. : | 117928-94-6 |
Formula : | C18H31N5O6 |
M.W : | 413.47 |
SMILES Code : | O=C([C@@H]1CCCN1C([C@H]([C@@H](C)O)N)=O)N2CCC[C@H]2C(N[C@@H]([C@@H](C)O)C(N)=O)=O |
Synonyms : |
GLYX-13; BV-102; TPPT-amide
|
MDL No. : | MFCD12912477 |
InChI Key : | GIBQQARAXHVEGD-BSOLPCOYSA-N |
Pubchem ID : | 14539800 |
GHS Pictogram: |
![]() |
Signal Word: | Warning |
Hazard Statements: | H302-H315-H319-H335 |
Precautionary Statements: | P261-P305+P351+P338 |
In Vitro:
Cell Line
|
Concentration | Treated Time | Description | References |
CA1 pyramidal cells | 1 μM | 25–30 min | GLYX-13 reduced inhibitory input onto CA1 pyramidal cells and increased synaptically driven pyramidal cell excitability. | PMC5879689 |
Rat cortical neurons | 10-300 nM | Rapastinel enhanced NMDA-induced calcium influx | PMC6403082 | |
HEK cells | 30-100 nM | Rapastinel enhanced NMDAR-dependent neuronal intracellular calcium mobilization | PMC6403082 |
In Vivo:
Species
|
Animal Model
|
Administration | Dosage | Frequency | Description | References |
Mice | Long-term isoflurane exposure-induced cognitive impairment model | Intravenous injection | 1 mg/kg | Single dose, lasting 2 hours | GLYX-13 pretreatment alleviates isoflurane-induced cognitive dysfunction by protecting against perturbation of the NR2B/CaMKII/CREB signaling pathway | PMC6862406 |
Rats | Depression model | Subcutaneous injection | 10 and 30 mg/kg | Single dose | Rapastinel produced rapid and sustained antidepressant-like effects in rat mPFC | PMC6403082 |
Mice | Chronic unpredictable stress (CUS) model | Intravenous injection | 0.5, 5, and 10 mg/kg | 3 consecutive days | Rapastinel significantly reversed CUS-induced depression-like behaviors and produced antidepressant effects by enhancing ERK/mTOR/VGF/BDNF/TrkB signaling. | PMC9780240 |
Clinical Trial:
NCT Number | Conditions | Phases | Recruitment | Completion Date | Locations |
NCT01234558 | Major Depressive Disorder | PHASE2 | COMPLETED | 2025-07-12 | Mulitple, Evanston, Illinois, ... More >>60201, United States Less << |
NCT03668600 | Depressive Disorder, Major | PHASE3 | TERMINATED | 2019-07-03 | University of Alabama at Birmi... More >>ngham, Birmingham, Alabama, 35294, United States|Harmonex Neuroscience Research, Dothan, Alabama, 36303, United States|NoesisPharma, Phoenix, Arizona, 85016, United States|Woodland International Research Group, Little Rock, Arkansas, 72211, United States|Woodland Research Northwest, Rogers, Arkansas, 72758, United States|California Pharmaceutical Research Institute, Inc, Anaheim, California, 92804, United States|Southern California Research LLC., Beverly Hills, California, 90036, United States|ATP Clinical Research Inc., Costa Mesa, California, 92626, United States|ProScience Research Group, Culver City, California, 90230, United States|Pharmacology Research Institute, Encino, California, 91316, United States|Behavioral Research Specialists, LLC, Glendale, California, 91206, United States|Sun Valley Research Center, Imperial, California, 92251, United States|Irvine Center for Clinical Research, Inc, Irvine, California, 92614, United States|Synergy Clinical Research Center of Escondido, Lemon Grove, California, 91945, United States|Pharmacology Research Institute, Los Alamitos, California, 90720, United States|CITrials, Riverside, California, 92506, United States|California Neuroscience Research, Sherman Oaks, California, 91403, United States|Viking Clinical Research, Temecula, California, 92591, United States|Pacific Clinical Research Medical, Upland, California, 91786, United States|Comprehensive Psychiatric Care, Norwich, Connecticut, 06360, United States|Gulfcoast Clinical Research Center, Fort Myers, Florida, 33912, United States|Reliable Clinical Research, Hialeah, Florida, 33012, United States|Meridien Research, Lakeland, Florida, 33805, United States|Innovative Clinical Research, Inc, Lauderhill, Florida, 33319, United States|Research Centers of America, Oakland Park, Florida, 33334, United States|Medical Research Group of Central Florida, Orange City, Florida, 32763, United States|David A. Medina, MD, Orlando, Florida, 32819, United States|Institute for Advanced Medical Research, Atlanta, Georgia, 30341, United States|iResearch Atlanta, LLC, Decatur, Georgia, 30030, United States|Northwest Behavioral Research Center, Marietta, Georgia, 30060, United States|Attalla Consultants, LLC, Smyrna, Georgia, 30082, United States|Alexian Brothers Center for Psychiatric Research, Hoffman Estates, Illinois, 60169, United States|Capstone Clinical Research, Libertyville, Illinois, 60048, United States|AMR - Baber Research, Inc., Naperville, Illinois, 60563, United States|University of Kansas School of Medicine Clinical Trial Unit, Wichita, Kansas, 67214, United States|Lake Charles Clinical Trials, Lake Charles, Louisiana, 70629, United States|Louisiana Clinical Research, Shreveport, Louisiana, 71101, United States|ActivMed Practices & Research, Inc., Methuen, Massachusetts, 01844, United States|Coastal Research Associates, South Weymouth, Massachusetts, 02190, United States|University of Massachusetts Medical School, Worcester, Massachusetts, 01655, United States|Precise Research Centers, Flowood, Mississippi, 39232, United States|Psychiatric Care and Research Center, O'Fallon, Missouri, 63368, United States|St. Charles Psychiatric Associates, Saint Charles, Missouri, 63304, United States|Premier Psychiatric Research Institute, LLC, Lincoln, Nebraska, 68526, United States|Healthy Perspectives - Innovative Mental Health Services. PLLC, Nashua, New Hampshire, 03060, United States|Bio Behavioral Health, Toms River, New Jersey, 08755, United States|Albuquerque Neuroscience, Inc, Albuquerque, New Mexico, 87109, United States|SPRI Clinical Trials, LLC, Brooklyn, New York, 11235, United States|Manhattan Behavioral Medicine, New York, New York, 10022, United States|Finger Lakes Clinical Research, Rochester, New York, 14618, United States|Richmond Behavioral Associates, Staten Island, New York, 10312, United States|Patient Priority Clinical Sites, Cincinnati, Ohio, 45215, United States|The Ohio State University Department of Psychiatry, Columbus, Ohio, 43210, United States|Midwest Clinical Research Center LLC, Dayton, Ohio, 45417, United States|Professional Psychiatric Services, Mason, Ohio, 45040, United States|Red River Medical Research Center, LLC, Oklahoma City, Oklahoma, 73112, United States|Sooner Clinical Research, Inc, Oklahoma City, Oklahoma, 73112, United States|Paradigm Research Professionals, Oklahoma City, Oklahoma, 73118, United States|Summit Research Network LLC, Portland, Oregon, 97210, United States|Lehigh Center for Clinical Research, Allentown, Pennsylvania, 18104, United States|Dr. Cherian Verghese, Norristown, Pennsylvania, 19403, United States|Carolina Clinical Trials, Inc., Charleston, South Carolina, 29407, United States|Coastal Carolina Research Center, Mount Pleasant, South Carolina, 29464, United States|Research Strategies of Memphis, LLC, Memphis, Tennessee, 38119, United States|Donald J. Garcia, Jr., MD, PA, Austin, Texas, 78737, United States|Community Clinical Research, Austin, Texas, 78754, United States|Houston Clinical Trials, Bellaire, Texas, 77401, United States|North Texas Clinical Trials, Fort Worth, Texas, 76104, United States|Earle Research, Houston, Texas, 77058, United States|Red Oak Psychiatry Associates, PA, Houston, Texas, 77090, United States|Clinical Trials of Texas, San Antonio, Texas, 78229, United States|Grayline Clinical Drug Trials, Wichita Falls, Texas, 76309, United States|Psychiatric and Behavioral Solutions, Salt Lake City, Utah, 84105, United States|Psychiatric Alliance of the Blue Ridge, Inc, Charlottesville, Virginia, 22903, United States Less << |
NCT03002077 | Depressive Disorder, Major | PHASE3 | COMPLETED | 2018-12-06 | University of Alabama at Birmi... More >>ngham, Birmingham, Alabama, 35294, United States|Harmonex, Inc., Dothan, Alabama, 36303, United States|NoesisPharma, Phoenix, Arizona, 85032, United States|Woodland International Research Group, Little Rock, Arkansas, 72211, United States|Woodland Research Northwest, Rogers, Arkansas, 72758, United States|California Pharmaceutical Research Institute, Inc, Anaheim, California, 92804, United States|Southern California Research LLC., Beverly Hills, California, 90036, United States|ATP Clinical Research Inc., Costa Mesa, California, 92626, United States|ProScience Research Group, Culver City, California, 90230, United States|Collaborative Neuroscience Network, LLC, Garden Grove, California, 92845, United States|Behavioral Research Specialists, LLC, Glendale, California, 91206, United States|Sun Valley Research Center, Imperial, California, 92251, United States|Irvine Center for Clinical Research, Inc, Irvine, California, 92614, United States|Synergy Clinical Research Center of Escondido, Lemon Grove, California, 91945, United States|Synergy San Diego, Lemon Grove, California, 91945, United States|Pharmacology Research Institute, Los Alamitos, California, 90720, United States|Pacific Research Partners; LLC., Oakland, California, 94607, United States|Excell Research, Oceanside, California, 92056, United States|NRC Research Institute, Orange, California, 92868, United States|Asclepes Research Centers, Panorama City, California, 91402, United States|Anderson Clinical Research, Redlands, California, 92374, United States|CITrials, Riverside, California, 92506, United States|Artemis Institute for Clinical Research, San Diego, California, 92103, United States|PCSD Feighner Research, San Diego, California, 92108, United States|Artemis Institute for Clinical Research, San Marcos, California, 92078, United States|Thomas M. Shiovitz, M.D., Inc., DBA California Neuroscience Research Medical Group, Inc.,, Sherman Oaks, California, 91403, United States|Viking Clinical Research, Temecula, California, 92591, United States|Pacific Clinical Research Medical, Upland, California, 91786, United States|MCB Clinical Research Center, Colorado Springs, Colorado, 80910, United States|Comprehensive Psychiatric Care, Norwich, Connecticut, 06360, United States|Meridien Research, Bradenton, Florida, 34201, United States|Gulfcoast Clinical Research Center, Fort Myers, Florida, 33912, United States|Sarkis Clinical Trials, Gainesville, Florida, 32607, United States|MD Clinical, Hallandale Beach, Florida, 33009, United States|Reliable Clinical Research, Hialeah, Florida, 33012, United States|Clinical Neuroscience Solutions, Inc, Jacksonville, Florida, 32256, United States|Meridien Research, Lakeland, Florida, 33805, United States|Innovative Clinical Research, Inc, Lauderhill, Florida, 33319, United States|Innova Clinical Trials Inc., Miami, Florida, 33145, United States|International Research Associates, LLC, Miami, Florida, 33183, United States|Research Centers of America, Oakland Park, Florida, 33334, United States|Medical Research Group of Central Florida, Orange City, Florida, 32763, United States|Clinical Neuroscience Solutions, Inc, Orlando, Florida, 32801, United States|Combined Research Orlando Phase I-IV, Orlando, Florida, 32807, United States|Millenia Psychiatry & Research, Inc, Orlando, Florida, 32839, United States|Olympian Clinical Research, Tampa, Florida, 33609, United States|University of South Florida, Psychiatry and Behavioral Neurosciences, Tampa, Florida, 33613, United States|Institute for Advanced Medical Research, Atlanta, Georgia, 30005, United States|Atlanta Center for Medical Research, Atlanta, Georgia, 30331, United States|iResearch Atlanta, LLC, Decatur, Georgia, 30030, United States|Northwest Behavioral Research Center, Marietta, Georgia, 30060, United States|Iris Research, Smyrna, Georgia, 30080, United States|Great Lakes Clinical Trials, Chicago, Illinois, 60640, United States|Alexian Brothers Center for Psychiatric Research, Hoffman Estates, Illinois, 60169, United States|Capstone Clinical Research, Libertyville, Illinois, 60048, United States|AMR - Baber Research, Inc., Naperville, Illinois, 60563, United States|Psychiatric Associates, Overland Park, Kansas, 66211, United States|Heartland Research Associates, Wichita, Kansas, 67207, United States|Lake Charles Clinical Trials, Lake Charles, Louisiana, 70629, United States|Louisiana Clinical Research, Shreveport, Louisiana, 71101, United States|J Gary Booker, MD APMC, Shreveport, Louisiana, 71104, United States|Sheppard Pratt Health System, Baltimore, Maryland, 21204, United States|Pharmasite Research, Inc, Baltimore, Maryland, 21208, United States|CBH Health, Gaithersburg, Maryland, 20850, United States|Boston Clinical Trials, Boston, Massachusetts, 02131, United States|ActivMed Practices & Research, Inc., Methuen, Massachusetts, 01844, United States|Coastal Research Associates, South Weymouth, Massachusetts, 02190, United States|Adams Clinical Trials, Watertown, Massachusetts, 02472, United States|University of Massachusetts Medical School, Worcester, Massachusetts, 01655, United States|Precise Research Centers, Flowood, Mississippi, 39232, United States|Psychiatric Care and Research Center, O'Fallon, Missouri, 63368, United States|St. Charles Psychiatric Associates - Midwest Research Group, Saint Charles, Missouri, 63304, United States|Millennium Psychiatric Associates, Saint Louis, Missouri, 63141, United States|Premier Psychiatric Research Institute, LLC, Lincoln, Nebraska, 68526, United States|Altea Research, Las Vegas, Nevada, 89102, United States|Healthy Perspectives - Innovative Mental Health Services. PLLC, Nashua, New Hampshire, 03060, United States|Hassman Research Institute, LLC, Berlin, New Jersey, 08009, United States|Center for Emotional Fitness, Cherry Hill, New Jersey, 08002, United States|Pharmaceutical Research Associates Inc, Marlton, New Jersey, 08053, United States|Global Medical Institute, LLC, Princeton, New Jersey, 08540, United States|Bio Behavioral Health, Toms River, New Jersey, 08755, United States|Albuquerque Neuroscience, Inc, Albuquerque, New Mexico, 87109, United States|SPRI Clinical Trials, Inc, Brooklyn, New York, 11235, United States|Bioscience Research, Mount Kisco, New York, 10549, United States|Manhattan Behavioral Medicine, New York, New York, 10022, United States|Eastside Comprehensive Medical Center, LLC, New York, New York, 10128, United States|The Medical Research Network, LLC, New York, New York, 10128, United States|Fieve Clinical Research, New York, New York, 10168, United States|Finger Lakes Clinical Research, Rochester, New York, 14618, United States|Richmond Behavioral Associates, Staten Island, New York, 10312, United States|Carolina Clinical Trials, Inc., Charleston, North Carolina, 29407, United States|New Hope Clinical Research Inc., Charlotte, North Carolina, 28211, United States|Richard H. Weisler, MD, PA, Raleigh, North Carolina, 27609, United States|Neuro-Behavioral Clinical Research, Inc, Canton, Ohio, 44718, United States|Patient Priority Clinical Site, LLC, Cincinnati, Ohio, 45215, United States|The Ohio State University Department of Psychiatry, Columbus, Ohio, 43210, United States|Midwest Clinical Research Center LLC, Dayton, Ohio, 45417, United States|Charak Clinical Research Center, Garfield Heights, Ohio, 44125, United States|Lindner Center of Hope, Mason, Ohio, 45040, United States|Professional Psychiatric Services, Mason, Ohio, 45040, United States|IPS Research, Oklahoma City, Oklahoma, 73103, United States|Red River Medical Research Center, LLC, Oklahoma City, Oklahoma, 73112, United States|Sooner Clinical Research, Inc, Oklahoma City, Oklahoma, 73112, United States|Paradigm Research Professionals, Oklahoma City, Oklahoma, 73118, United States|Summit Research Network, Portland, Oregon, 97210, United States|Lehigh Center for Clinical Research, Allentown, Pennsylvania, 18104, United States|Suburban Research Associates, Media, Pennsylvania, 19063, United States|Keystone Clinical Studies, LLC, Norristown, Pennsylvania, 20006, United States|Coastal Carolina Research Center, Inc., Mount Pleasant, South Carolina, 29464, United States|Clinical Neuroscience Solutions, Inc, Memphis, Tennessee, 38119, United States|Research Strategies of Memphis, LLC, Memphis, Tennessee, 38119, United States|Donald J. Garcia, Jr., MD, PA, Austin, Texas, 78737, United States|Community Clinical Research, Inc., Austin, Texas, 78754, United States|BioBehavioral Research of Austin, Austin, Texas, 78759, United States|Houston Clinical Trials, LLC, Bellaire, Texas, 77401, United States|Relaro Medical Trials, Dallas, Texas, 75243, United States|El Campo Clinical Trials, El Campo, Texas, 77347, United States|North Texas Clinical Trials, Fort Worth, Texas, 76104, United States|Earle Research, Houston, Texas, 77058, United States|Red Oak Psychiatry Associates, PA, Houston, Texas, 77090, United States|Clinical Trials of Texas, San Antonio, Texas, 78229, United States|Family Psychiatry of The Wood, The Woodlands, Texas, 77381, United States|Grayline Clinical Drug Trials, Wichita Falls, Texas, 76309, United States|Psychiatric and Behavioral Solutions, Salt Lake City, Utah, 84105, United States|Pharmaceutical Research Associates, Inc, Salt Lake City, Utah, 84106, United States|Psychiatric Alliance of the Blue Ridge, Inc., Charlottesville, Virginia, 22903, United States|NorthWest Clinical Research Center, Bellevue, Washington, 98007, United States|Pacific Institute of Medical Sciences, Bothell, Washington, 98011, United States Less << |
Bio Calculators | ||||
Preparing Stock Solutions | ![]() |
1mg | 5mg | 10mg |
1 mM 5 mM 10 mM |
2.42mL 0.48mL 0.24mL |
12.09mL 2.42mL 1.21mL |
24.19mL 4.84mL 2.42mL |
Tags: Rapastinel | GLYX-13 | GLYX13 | GLYX 13 | iGluR | Ionotropic glutamate receptors | NMDAR modulator | glycine site partial agonist | synaptic plasticity | glutamatergic signaling | 117928-94-6
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H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
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