Size	Price	VIP Price	US Stock	Global Stock	In Stock
{[ item.pr_size ]}		Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

CAS No. :	1020315-31-4
Formula :	C₂₃H₂₀F₃N₅O₂
M.W :	455.43
SMILES Code :	O=C(N(CC1)CCC1=CC2=CC(OC3=CC=C(C=N3)C(F)(F)F)=CC=C2)NC4=CC=CN=N4
Synonyms :	PF-04457845; PF-4457845; PF4457845, redafamdastat
MDL No. :	MFCD18782721
InChI Key :	BATCTBJIJJEPHM-UHFFFAOYSA-N
Pubchem ID :	24771824

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H315-H320-H335
Precautionary Statements:	P261-P280-P301+P312-P302+P352-P305+P351+P338

HEK293T cells	0.0040 µM (IC50)	30 minutes	Inhibition of FAAH activity	Science. 2017 Jun 9;356(6342):1084-1087
HEK293T cells	0.011 µM (IC50)	4 hours	Inhibition of FAAH activity	Science. 2017 Jun 9;356(6342):1084-1087
Rat FAAH (rFAAH)	1 nM to 10 µM	1 to 60 minutes	PF-04457845 inhibited rFAAH with high potency (kinact/Ki value of 32,400 M−1s−1; IC50 of 7.4 nM) via an irreversible mechanism.	J Pharmacol Exp Ther. 2011 Jul;338(1):114-24
Human FAAH (hFAAH)	5 to 625 nM	1 to 60 minutes	PF-04457845 inhibited hFAAH with high potency (kinact/Ki value of 40,300 M−1s−1; IC50 of 7.2 nM) via an irreversible mechanism (i.e., carbamylation of the catalytic serine nucleophile).	J Pharmacol Exp Ther. 2011 Jul;338(1):114-24
COS-7 cells	0.3 to 3000 nM	1, 3, or 24 hours	Evaluation of PF-04457845's inhibitory effect on human recombinant FAAH, showing that PF-04457845 exhibited potent FAAH inhibitory activity in COS-hFAAH cells.	Br J Pharmacol. 2020 May;177(9):2123-2142
HK-2 cells	1 µM	30 min pretreatment followed by 48 hours	Inhibited TGF-β1-induced profibrogenic markers, restored epithelial marker E-cadherin expression, and maintained cell morphology.	Biochim Biophys Acta Mol Basis Dis. 2022 Oct 1;1868(10):166456
Rat FAAH (rFAAH)	7.4 nM (IC50)	60 min preincubation	Evaluate the inhibitory activity of PF-04457845 on rFAAH, showing high inhibitory potency	ACS Med Chem Lett. 2011 Feb 10;2(2):91-96
Human FAAH (hFAAH)	7.2 nM (IC50)	60 min preincubation	Evaluate the inhibitory activity of PF-04457845 on hFAAH, showing high inhibitory potency	ACS Med Chem Lett. 2011 Feb 10;2(2):91-96
HN12 (p53 mutant)	1 µM and 2 µM	Day 3 and Day 6	To evaluate the effect of FAAH inhibitor on the antitumor efficacy of cisplatin, results showed that FAAH inhibitor did not interfere with the antitumor effect of cisplatin on HN12 cells	Mol Pharmacol. 2023 Apr;103(4):230-240
HN30 (p53 wild-type)	1 µM and 2 µM	Day 3 and Day 6	To evaluate the effect of FAAH inhibitor on the antitumor efficacy of cisplatin, results showed that FAAH inhibitor did not interfere with the antitumor effect of cisplatin on HN30 cells	Mol Pharmacol. 2023 Apr;103(4):230-240

Rats	Complete Freund’s adjuvant (CFA)-induced inflammatory pain model	Oral	0.003 to 10 mg/kg	Single administration, lasting 24 hours	PF-04457845 exhibited significant analgesic effects in the CFA model (minimum effective dose of 0.1 mg/kg), accompanied by near-complete inhibition of FAAH activity and sustained elevation of anandamide levels in the brain. Additionally, PF-04457845 at 10 mg/kg had no effect on motility, catalepsy, or body temperature.	J Pharmacol Exp Ther. 2011 Jul;338(1):114-24
Rats	Juvenile rats	Oral gavage	0.02 mg/kg	Daily for 7 days	To investigate the effects of developmental PF-04457845 exposure on behavior, results showed increased motor activity and social play behavior.	Neurotoxicology. 2020 Mar;77:127-136
Rat	Juvenile rat model	Oral	0.02 mg/kg	Once daily from postnatal day 10 to day 16	To investigate the inhibition of FAAH by PF-04457845 and its long-term effects on protein expression in the amygdala. Results showed that PF-04457845 significantly inhibited FAAH activity and led to differential expression of 142 proteins in the amygdala during adolescence (PND38), affecting glutamatergic and GABAergic signaling pathways.	Neurotoxicology. 2021 Jul;85:234-244
Mice	NMRI mice	Oral	0.03 and 0.1 mg/kg	Single dose	Evaluation of the pharmacodynamic and pharmacokinetic properties of PF-04457845 in mice, showing that PF-04457845 was detectable in both plasma and brain, with brain exposure approximately 10-fold lower than in plasma.	Br J Pharmacol. 2020 May;177(9):2123-2142
Mice	Chronic constriction injury (CCI) model	Intraperitoneal injection	0.05, 0.1, 0.5, and 1.0 mg/kg	Single dose, behavioral tests conducted 2 hours post-injection	To determine the dose-dependent effects of PF04457845 on CCI-induced thermal hyperalgesia and mechanical allodynia. Results showed that 1.0 mg/kg PF04457845 completely blocked both thermal hyperalgesia and mechanical allodynia in CCI mice.	Cells. 2023 Apr 27;12(9):1275
Rats	CFA-induced inflammatory pain model	Oral	0.1 mg/kg	Single dose, evaluated after 4 hours	Evaluate the analgesic effect of PF-04457845 in an inflammatory pain model, showing significant reduction in mechanical allodynia at 0.1 mg/kg dose	ACS Med Chem Lett. 2011 Feb 10;2(2):91-96
Rats	Sprague-Dawley rats	Oral	1 mg/kg	Single dose, 1 hour before tracer injection	Evaluate the inhibitory effect of PF-04457845 on FAAH, showing significant reduction of tracer uptake in all brain regions (37%–73% at 90 min)	Nucl Med Biol. 2012 Oct;39(7):1058-67
Human	Healthy volunteers	Oral	1, 4, or 20 mg	Single dose	To evaluate the inhibitory effect of PF-04457845 on FAAH activity in the human brain. Results showed that PF-04457845 inhibited ≥91% of FAAH activity at a dose of 1 mg.	J Cereb Blood Flow Metab. 2015 Nov;35(11):1827-35
Rat	Pain model	Oral	10 mg	Single dose	To evaluate the in vivo efficacy of PF-04457845 in a pain model, showing good efficacy.	CPT Pharmacometrics Syst Pharmacol. 2014 Jan 15;3(1):e91
Male Sprague-Dawley rats	Acute restraint stress model	Intraperitoneal (i.p.) or intracerebroventricular (i.c.v.)	10 mg/kg (systemic), 3 μg or 30 μg (intracerebroventricular)	Single dose, 2 hours before stress	To assess the effects of PF-04457845 on homeostatic feeding and stress-induced changes in food intake. Results showed that i.c.v. administration of 30 μg PF-04457845 attenuated stress-induced anorexia via CB1 receptors but reduced homeostatic feeding in unstressed animals through an unknown mechanism.	Br J Pharmacol. 2019 May;176(10):1524-1540
Mice	Complete Freund’s adjuvant (CFA)-induced arthritis model	Oral	1–30 mg/kg	Single administration on day 3, 7, or 14 after CFA injection	To evaluate the antihyperalgesic effects of PF-04457845 in a chronic inflammatory pain model. Results showed that PF-04457845 significantly reduced mechanical and thermal hyperalgesia at doses of 3–30 mg/kg, but was less effective than URB937.	Pharmacol Res. 2012 May;65(5):553-63
Sprague Dawley rats	Early-life inflammation model	Oral or intra-amygdala	1mg/kg (oral) or 10ng (intra-amygdala)	Single administration, testing window 4-6 hours post-administration	To evaluate the ameliorative effects of FAAH inhibitor on social behavior deficits induced by early-life inflammation. Results showed that PF-04457845 reversed LPS-induced social behavior deficits but had no significant effect on the control group.	Brain Behav Immun. 2016 Nov;58:237-247
C57BL/6 male mice	No specific model used	Intranasal, intraperitoneal, and oral	5 mg/kg	Every other day for 20 days for a total of 10 drug treatments	To evaluate the inhibitory effects of PF-04457845 on FAAH activity via different administration routes. Results showed that PF-04457845 potently inhibits FAAH regardless of the route selected.	Int J Mol Sci. 2019 Sep 11;20(18):4503

{[proInfo.proName]}

CAS No.: 1020315-31-4

{[proInfo.proName]}

CAS No.: 1020315-31-4

Alternative Products

Product Details of Redafamdastat

Safety of Redafamdastat

Isoform Comparison

Biological Activity

Protocol

References

Historical Records

Categories

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

Molarity Calculator

Total Compounds Calculator

Dissolution Calculator

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed