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Chemical Structure| 737789-87-6 Chemical Structure| 737789-87-6

Structure of Relugolix
CAS No.: 737789-87-6

Chemical Structure| 737789-87-6

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Relugolix is a non-peptide, orally active gonadotropin-releasing hormone (GnRH) antagonist with IC50 of 0.33 nM in the presence of 40% fetal bovine serum. It possesses higher affinity and potent antagonistic activity compared with TAK-013.

Synonyms: TAK-385; RVT-601

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Product Details of Relugolix

CAS No. :737789-87-6
Formula : C29H27F2N7O5S
M.W : 623.63
SMILES Code : O=C(NOC)NC1=CC=C(C(S2)=C(CN(C)C)C(C(N3C4=NN=C(OC)C=C4)=O)=C2N(CC5=C(F)C=CC=C5F)C3=O)C=C1
Synonyms :
TAK-385; RVT-601
MDL No. :MFCD25976856
InChI Key :AOMXMOCNKJTRQP-UHFFFAOYSA-N
Pubchem ID :10348973

Safety of Relugolix

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Related Pathways of Relugolix

GPCR

Isoform Comparison

Biological Activity

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT05467176 Prostate Cancer ACTIVE_NOT_RECRUITING 2028-05-31 Urology Centers of Alabama, Ho... More >>mewood, Alabama, 35209, United States|Urology Associates of Mobile, Mobile, Alabama, 36607, United States|Dignity Health, Phoenix, Arizona, 85013, United States|Arizona Urology Specialists, PLLC, Tucson, Arizona, 85704, United States|Arkansas Urology Research Center, Little Rock, Arkansas, 72211, United States|City of Hope, Duarte, California, 91010, United States|Urology Associates of Central California, Fresno, California, 93720, United States|UCSD, La Jolla, California, 92097, United States|USC Norris Cancer Center, Los Angeles, California, 90033, United States|Tower Urology, Los Angeles, California, 90048, United States|VA Greater Los Angeles Medical Center, Los Angeles, California, 90073, United States|Tri Valley Urology, Murrieta, California, 92562, United States|Genesis Research LLC, San Diego, California, 92123, United States|Golden State Urology, Stockton, California, 95219, United States|Rocky Mountain Regional VA Medical Center, Aurora, Colorado, 80045, United States|The Urology Center of Colorado, Denver, Colorado, 80211, United States|Banner MD Anderson Cancer Center, Greeley, Colorado, 80631, United States|Colorado Urology, Lakewood, Colorado, 80228, United States|Urology Associates, Lone Tree, Colorado, 80124, United States|The Stamford Hospital, Stamford, Connecticut, 06902, United States|Urologic Surgeons of Washington, Washington, D.C., District of Columbia, 20036, United States|MemorialCare, Long Beach Memorial Medical Center, Washington, District of Columbia, 20037, United States|Bay Pines VA Healthcare System, Bay Pines, Florida, 33744, United States|Manatee Medical Research Institute, LLC, Bradenton, Florida, 34205, United States|Advanced Urology Institute, Daytona Beach, Florida, 32114, United States|Memorial Healthcare System, Hollywood, Florida, 33021, United States|United Medical Group, Miami, Florida, 33135, United States|SG Research LLC, Miami, Florida, 33145, United States|Genesis Care USA, Naples, Florida, 34119, United States|Florida Urology Partners, LLP, Tampa, Florida, 33607, United States|Emory University, Atlanta, Georgia, 30342, United States|Georgia Urology, Decatur, Georgia, 30033, United States|PRiSMS Group LLC, Arlington Heights, Illinois, 60005, United States|Associated Urological Specialists, Chicago Ridge, Illinois, 60415, United States|Northwestern University, Evanston, Illinois, 60208, United States|UroPartners Research, Glenview, Illinois, 60026, United States|Comprehensive Urologic Care, Lake Barrington, Illinois, 60010, United States|Duly Health and Care, Lisle, Illinois, 60532, United States|Advanced Urology Associates, New Lenox, Illinois, 60451, United States|Urology of Indiana, Carmel, Indiana, 46032, United States|Urologic Specialists of Northwest Indiana, Merrillville, Indiana, 46410, United States|Greater Regional Health, Creston, Iowa, 50801, United States|University of Kansas Medical Center, Kansas City, Kansas, 66160, United States|Wichita Urology Group, P.A., Wichita, Kansas, 67226, United States|Baptists Health Lexington, Lexington, Kentucky, 40503, United States|Southern Urology, Lafayette, Louisiana, 70508, United States|John Hopkins, Baltimore, Maryland, 20777, United States|Chesapeake Urology Associates, Baltimore, Maryland, 21204, United States|Maryland Oncology Hematology, Columbia, Maryland, 21044, United States|Medstar Georgetown University Hospital, Columbia, Maryland, 21044, United States|Michigan Institute of Urology, Troy, Michigan, 48084, United States|GenesisCare USA, Troy, Michigan, 48098, United States|Minnesota Urology, Woodbury, Minnesota, 55125, United States|Specialty Clinical Research of St. Louis, Saint Louis, Missouri, 63141, United States|Summit Medical Group, P.A. | New Jersey Urology, Berkeley Heights, New Jersey, 907922, United States|AtlanticCare Cancer Institute, Egg Harbor Township, New Jersey, 08234, United States|The Valley Hospital, Paramus, New Jersey, 07652, United States|Regional Cancer Care Associates, Teaneck, New Jersey, 07666, United States|Crystal Run Healthcare, Middletown, New York, 10941, United States|Optum Medical Care, P. C., Mount Kisco, New York, 10549, United States|Mount Sinai Hospital, New York, New York, 10029, United States|SUNY Upstate Medical Institution, Syracuse, New York, 13210, United States|Associated Medical Professionals of NY, PLLC, Syracuse, New York, 95054, United States|Mohawk Valley Health Services, Utica, New York, 13502, United States|DJL Clinical Research, PLLC, Charlotte, North Carolina, 28210, United States|Durham VA Healthcare, Durham, North Carolina, 27705, United States|GenesisCare USA, Greenville, North Carolina, 27834, United States|Associated Urologist of North Carolina, Raleigh, North Carolina, 27612, United States|Clinical Inquest Center Ltd, Beavercreek, Ohio, 45431, United States|NEO Urology Associates, Inc., Boardman, Ohio, 44512, United States|University of Cincinnati Medical Center, Cincinnati, Ohio, 45267, United States|University Hospitals, Cleveland, Ohio, 44106, United States|Central Ohio Urology Group, Gahanna, Ohio, 43230, United States|Premier Clinical Research LLC dba STAT Research, Springboro, Ohio, 45440, United States|The University of Toledo, Toledo, Ohio, 43606, United States|Oregon Urology Institute, Springfield, Oregon, 97477, United States|Spokenword Clinical Trials, Easton, Pennsylvania, 18045, United States|Keystone Urology Specialist, Lancaster, Pennsylvania, 17604, United States|GU, Inc., Latrobe, Pennsylvania, 15650, United States|Carolina Urologic Research Center, LLC, Myrtle Beach, South Carolina, 29572, United States|Lowcountry Urology Clinics, North Charleston, South Carolina, 29406, United States|The Conrad Pearson Clinic, Germantown, Tennessee, 38138, United States|University of Tennessee Medical Center, Knoxville, Tennessee, 37920, United States|Urology Austin, Austin, Texas, 78759, United States|Hmu, Crc Llc, Houston, Texas, 77027, United States|MD Anderson, Houston, Texas, 77030, United States|New Horizon Medical Group, LLC, Houston, Texas, 77042, United States|Ascend Pharma Holdings, Houston, Texas, 77079, United States|Urology San Antonio, P.A. dba USA Clinical Trials, San Antonio, Texas, 78229, United States|The Urology Place, San Antonio, Texas, 78240, United States|Potomac Urology Center, PC, Alexandria, Virginia, 22311, United States|MedAtlantic, Richmond, Virginia, 23235, United States|Urology of Virginia, PLLC, Virginia Beach, Virginia, 23462, United States|Spokane Urology, P.S., Spokane, Washington, 99202, United States|Wisconsin Institute of Urology, Neenah, Wisconsin, 54956, United States|Aspirus, Wausau, Wisconsin, 54401, United States Less <<
NCT02141659 Hormone Treatment-na?ve Partic... More >>ipants With Prostate Cancer Less << PHASE1 COMPLETED 2017-04-20 Sakura-shi, Chiba, Japan|Maeba... More >>shi-shi, Gunma, Japan|Sapporo-shi, Hokkaido, Japan|Kanazawa-shi, Ishikawa, Japan|Yokohama-shi, Kanagawa, Japan|Chiyoda-ku, Tokyo, Japan Less <<
NCT06462014 Prostate Cancer ACTIVE_NOT_RECRUITING 2025-12-31 Pfizer, New York, New York, 10... More >>001, United States Less <<

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.60mL

0.32mL

0.16mL

8.02mL

1.60mL

0.80mL

16.04mL

3.21mL

1.60mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

References

 

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