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Chemical Structure| 1173671-63-0 Chemical Structure| 1173671-63-0

Structure of Rhosin
CAS No.: 1173671-63-0

Chemical Structure| 1173671-63-0

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Rhosin is a specific Rho inhibitor which binds to WT RhoA with an affinity ~0.4 μM Kd while does not interfere with the binding of Cdc42 or Rac1.

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Product Citations

Product Citations

Miao, Zhijun ; Xu, Anan ; Shen, Gang ; Tang, Siyi ; Luo, Jie ; Yang, Jiajian , et al.

Abstract: Immunogenic cell death (ICD) induced by chemotherapeutics holds promise for cancer therapy, but limited drug penetration across the bladder mucosa and an immune-excluded tumor microenvironment (TME) have hindered success in bladder cancer. Here, we develop fluorinated albumin nanocages as transmucosal delivery vesicles that concurrently target cancer-associated fibroblasts (CAFs) and tumor cells to potentiate chemoimmunotherapy. Surface fluorination enables mucosal penetration, while recognition of secreted protein acidic and cysteine-rich (SPARC) protein ensures selective uptake by CAFs and tumor cells. Encapsulated chemotherapeutics enhance ICD through inhibition of the pathway, promoting tumor cell death. Simultaneous CAF disruption reduces stromal fibrosis, facilitating anti-PD-L1 antibody delivery and T-cell infiltration. This dual-targeting strategy synergizes ICD with immune checkpoint blockade to eradicate bladder tumors by recruiting cytotoxic T cells and suppressing immunosuppressive phenotypes. Ex vivo studies in freshly resected human bladder tumors further validated the translational potential. Our findings highlight fluorinated albumin nanocages as a versatile transmucosal platform to remodel the tumor-stroma axis and amplify chemoimmunotherapy in bladder cancer.

Keywords: uorinated albumin nanocages ; transmucosal delivery ; cancer-associated fibroblasts ; chemoimmunotherapy ; bladder cancer

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Product Details of Rhosin

CAS No. :1173671-63-0
Formula : C20H18N6O
M.W : 358.40
SMILES Code : O=C(N/N=C/C1=CC=C2N=CC=NC2=C1)[C@H](N)CC3=CNC4=C3C=CC=C4
MDL No. :MFCD04006470

Safety of Rhosin

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Related Pathways of Rhosin

GPCR

Isoform Comparison

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.79mL

0.56mL

0.28mL

13.95mL

2.79mL

1.40mL

27.90mL

5.58mL

2.79mL

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