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Chemical Structure| 324579-65-9 Chemical Structure| 324579-65-9

Structure of RNF5 inhibitor inh-02
CAS No.: 324579-65-9

Chemical Structure| 324579-65-9

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RNF5 inhibitor inh-02 is a potent inhibitor of the E3 ubiquitin ligase RNF5/RMA1. It significantly restores F508del-CFTR in bronchial epithelial cells with the F508del mutation (EC50 = 2.2 μM), making it suitable for cystic fibrosis research.

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Product Details of RNF5 inhibitor inh-02

CAS No. :324579-65-9
Formula : C23H20N4S
M.W : 384.50
SMILES Code : CC(N1CC2=CC=CC=C2)=NSC1=NC(C3=CC=CC=C3)=NC4=CC=CC=C4

Safety of RNF5 inhibitor inh-02

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H302-H318
Precautionary Statements:P280-P301+P312+P330-P305+P351+P338+P310
Class:9
UN#:3077
Packing Group:

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Biological Activity

Description
The RNF5 inhibitor inh-02 effectively inhibits the E3 ubiquitin ligase RNF5/RMA1. It results in substantial rescue of F508del-CFTR (EC50=2.2 μM) in bronchial epithelial cells carrying the F508del mutation. This inhibitor holds promise for cystic fibrosis research [1].

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Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.60mL

0.52mL

0.26mL

13.00mL

2.60mL

1.30mL

26.01mL

5.20mL

2.60mL

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