Rolipram | PDE4 Inhibitor

Size	Price	VIP Price	US Stock	Global Stock	In Stock
{[ item.pr_size ]}		Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

CAS No. :	61413-54-5
Formula :	C₁₆H₂₁NO₃
M.W :	275.34
SMILES Code :	O=C1NCC(C2=CC=C(OC)C(OC3CCCC3)=C2)C1
Synonyms :	(R,S)-Rolipram; ZK 62711; ME-3167
MDL No. :	MFCD00270906
InChI Key :	HJORMJIFDVBMOB-UHFFFAOYSA-N
Pubchem ID :	5092

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H315-H319-H335
Precautionary Statements:	P261-P305+P351+P338

J774 mouse macrophage cell line	2 μM	1 hour	Rolipram enhanced LPS-induced MKP-1 mRNA and protein expression and inhibited p38 MAPK phosphorylation.	PMC3724109
Primary mouse peritoneal macrophages	2 μM	1 hour	Rolipram enhanced LPS-induced MKP-1 mRNA expression.	PMC3724109
Human eosinophils	0.03-0.2 µM	15 minutes	To investigate the effect of Rolipram on PAF- and C5a-stimulated LTC4 synthesis in human eosinophils, results showed that Rolipram significantly inhibited LTC4 synthesis.	PMC1909817
DRG neurons	0.1, 0.25, 0.5, 1.0, and 2.0 µM	18 hours	Rolipram overcame inhibition by both MAG and myelin in a dose-dependent manner, completely blocking inhibition by MAG at 0.5 μM.	PMC423273
CHO cells	0.1, 0.25, 0.5, 1.0, and 2.0 µM	18 hours	Rolipram overcame inhibition by both MAG and myelin in a dose-dependent manner, completely blocking inhibition by MAG at 0.5 μM.	PMC423273
LX2 human hepatic stellate cells	10 μM	24 hours	Rolipram significantly attenuated TGF β1-mediated cell migration/wound closure	PMC10653049
U251 cells	100 μM	48 hours	To evaluate the cytotoxic effect of NEO214 on U251 cells, results showed that NEO214 was cytotoxic to both TMZ-sensitive and TMZ-resistant glioma cells.	PMC10621246
U251TR cells	100 μM	48 hours	To evaluate the cytotoxic effect of NEO214 on U251TR cells, results showed that NEO214 was cytotoxic to both TMZ-sensitive and TMZ-resistant glioma cells.	PMC10621246
T98G cells	100 μM	48 hours	To evaluate the cytotoxic effect of NEO214 on T98G cells, results showed that NEO214 was cytotoxic to both TMZ-sensitive and TMZ-resistant glioma cells.	PMC10621246
Rat mixed neural cell myelinating cultures	10 nM–10 μM	7 days	Rolipram enhanced neurite density in areas closely surrounding the lesion and induced significant neurite outgrowth across the lesion over a broad concentration range of 10 nM–10 μM. Rolipram enhanced myelination surrounding the lesion at a concentration range of 10–50 nM, but inhibited myelination at higher concentrations.	PMC3997278

Athymic rats	C5 hemisection model	Local delivery	Low dose: 25 µg/ml, High dose: 500 µg/ml	Single administration, lasted for 8 weeks	To evaluate the functional and anatomical recovery effects of Rolipram on spinal cord injury repair. Low-dose Rolipram significantly improved functional and anatomical recovery, while high-dose Rolipram was similar to the untreated group and resulted in reduced animal survival rates.	PMC3698241
Sprague- Dawley rats	Acute inflammation model	Intraperitoneal injection	8 mg/kg	Single dose, 30 minutes before the experiment	Rolipram significantly inhibited PAF and LPS-induced leukocyte rolling, adhesion, and emigration by 100%, 95%, and 95%, respectively. Additionally, Rolipram reversed the decrease in leukocyte rolling velocity induced by PAF.	PMC1573309
Sprague- Dawley rats	Conscious and anesthetized rats	Intravenous infusion	0–1 mg/kg	60 minutes	To measure the binding site density (B max) and radioligand affinity (1/K D) of 11C-(R)-rolipram in the rat brain, and to study the differences in binding between conscious and anesthetized states. Results showed that B max and K D were significantly higher in conscious rats compared to anesthetized rats, and the in vitro K D was 3–7 times greater than the in vivo K D.	PMC2791885
Long Evan Hooded rats	spinal cord hemisection model	subcutaneous injection	0.4 or 0.8 µmol/kg per hour	continuous for 10 days	Rolipram significantly promoted axon regeneration, attenuated the formation of the glial scar, and significantly enhanced functional recovery.	PMC423273
Nude mice	Intracranial glioma model	Subcutaneous injection	50 mg/kg	30 days, 5 days on, 2 days off	To evaluate the anti-tumor effect of NEO214 in an intracranial glioma model, results showed that NEO214 significantly delayed tumor growth and prolonged the survival of mice.	PMC10621246
BALB/c mice	LPS-induced lung inflammation model	Intraperitoneal injection	20 mg/kg	Single injection, lasting 45 minutes	To investigate the effect of Rolipram on LPS-induced lung inflammation, the results showed that Rolipram significantly reduced TNF-α levels in the BALF and almost completely inhibited LPS-induced neutrophil infiltration.	PMC1565207
C57BL/6 mice	Carrageenan-induced paw inflammation model	Intraperitoneal injection	100 mg/kg	Single dose, 3 hours duration	Rolipram significantly attenuated carrageenan-induced paw inflammation in WT mice but had no significant effect in MKP-1(–/–) mice.	PMC3724109
Balb/C mice	Klebsiella pneumoniae infection model	Oral	3–30 mg/kg	Administered 24 and 2 hours prior to infection and daily thereafter	To assess the effects of rolipram on the antibacterial host response in mice infected with Klebsiella pneumoniae. Results showed that rolipram treatment was associated with earlier lethality and significant inhibition of TNF-α production, along with enhanced IL-10 production in lung tissue. Rolipram treatment did not affect KC expression and neutrophil recruitment in lung tissue but inhibited neutrophil phagocytosis of K. pneumoniae.	PMC1574107
ICR mice	Antidepressant- and anxiolytic-like behavior model	Intraperitoneal injection	0.31, 0.62, 1.25 mg/kg	Once daily for 17-23 days	Rolipram produced antidepressant- and anxiolytic-like effects on behavior by increasing cAMP and pCREB levels in the hippocampus and prefrontal cortex, and increasing Sox2 expression in the hippocampus.	PMC2743762
Sprague- Dawley rats	Bone cancer pain model	Intrathecal injection	12.5, 25, 50, 100 µg/kg	Daily injection for 7 days	Rolipram significantly alleviated mechanical allodynia and thermal hyperalgesia in rats with bone cancer pain by inhibiting the spinal JNK/CCL2 signaling pathway and astrocytic activation	PMC5065302
C57BL/6J mice	CCl4-induced liver fibrosis model	Targeted hepatic delivery	3.3 mg/kg body weight	24 hours after each CCl4 administration, for 4 weeks	Rolipram attenuated SMAD3 signaling and stellate cell activation marker αSMA, reduced collagen deposition	PMC10653049

{[proInfo.proName]}

CAS No.: 61413-54-5

{[proInfo.proName]}

CAS No.: 61413-54-5

Alternative Products

Product Details of Rolipram

Safety of Rolipram

Isoform Comparison

Biological Activity

Protocol

References

Historical Records

Categories

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

Molarity Calculator

Total Compounds Calculator

Dissolution Calculator

NCT01805518	Adverse Mental/Physical Effect... More >>s of Low Dose S. Tortuosum. Less <<	Phase 1	Completed	-	Puerto Rico ... More >> Michel A. Woodbury, MD San Juan, Puerto Rico, 00918 Less <<
NCT02743377	Nervous System Disease	Phase 1 Phase 2	Recruiting	March 25, 2020	United States, Maryland ... More >> National Institutes of Health Clinical Center Recruiting Bethesda, Maryland, United States, 20892 Contact: For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR) 800-411-1222 ext TTY8664111010 prpl@cc.nih.gov Less <<
NCT01602900	Huntington Disease	Phase 1	Completed	-	United Kingdom ... More >> GSK Investigational Site London, United Kingdom, NW10 7EW GSK Investigational Site London, United Kingdom, W12 ONN Less <<
NCT00250172	Dosimetry Hea... More >>lthy Less <<	Phase 1	Completed	-	United States, Maryland ... More >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 Less <<
NCT01215552	Healthy Elderly Volunteers	Phase 1	Terminated(The experimental de... More >>sign was not sufficient to answer the proposed questions. A new study design is now being considered.) Less <<	-	United States, New York ... More >> Brookhaven National Laboratory Upton, New York, United States, 11973 Less <<
NCT00011375	Multiple Sclerosis	PHASE2	COMPLETED	2025-04-04	National Institute of Neurolog... More >>ical Disorders and Stroke (NINDS), Bethesda, Maryland, 20892, United States Less <<
NCT00369798	Major Depressive Disorder ... More >> Healthy Less <<	Phase 1	Completed	-	United States, Maryland ... More >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 Less <<

Bio Calculators
Preparing Stock Solutions		1mg	5mg	10mg
Preparing Stock Solutions	1 mM 5 mM 10 mM	3.63mL 0.73mL 0.36mL	18.16mL 3.63mL 1.82mL	36.32mL 7.26mL 3.63mL
Dissolving Methods	Animal experiment Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn: in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day; The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound. Protocol 1 Protocol 2

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed