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Chemical Structure| 2832047-80-8 Chemical Structure| 2832047-80-8

Structure of RP-6685
CAS No.: 2832047-80-8

Chemical Structure| 2832047-80-8

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RP-6685 is a selective and orally active DNA polymerase θ (Polθ) inhibitor with an IC50 of 5.8 nM. This compound demonstrates significant antitumor activity in mouse tumor xenograft models, making it suitable for cancer treatment and DNA damage repair research.

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Product Details of RP-6685

CAS No. :2832047-80-8
Formula : C22H14F7N5O
M.W : 497.37
SMILES Code : O=C(N(CC#CC1=NN=C(N)C=C1)C2=CC=C(F)C=C2)CC3=NC=C(C(F)(F)F)C=C3C(F)(F)F
MDL No. :MFCD34676750

Safety of RP-6685

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Related Pathways of RP-6685

DNA

Isoform Comparison

Biological Activity

Description
RP-6685, characterized by potent, selective, and oral activity as a DNA polymerase theta (Polθ) inhibitor, showcases an IC50 value of 5.8 nM in a PicoGreen assay and demonstrates antitumor efficacy in a mouse tumor xenograft model[1].

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