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Chemical Structure| 2262452-06-0 Chemical Structure| 2262452-06-0

Structure of RU.521
CAS No.: 2262452-06-0

Chemical Structure| 2262452-06-0

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RU.521 (RU320521) is a potent and selective inhibitor of cyclic GMP-AMP synthase (cGAS), inhibiting cGAS-mediated interferon upregulation with an IC50 of 0.7 μM. It also reduces interferon expression in macrophages from a mouse model of Aicardi-Goutières syndrome (AGS).

Synonyms: RU320521; RU-521

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Product Details of RU.521

CAS No. :2262452-06-0
Formula : C19H12Cl2N4O3
M.W : 415.23
SMILES Code : ClC1=C2C(N=C(N3C(O)=C(C4OC(C5=C4C=CC=C5)=O)C(C)=N3)N2)=CC=C1Cl
Synonyms :
RU320521; RU-521
MDL No. :MFCD32173679
InChI Key :IAWZUQAOMURCLV-UHFFFAOYSA-N
Pubchem ID :135397653

Safety of RU.521

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Isoform Comparison

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.41mL

0.48mL

0.24mL

12.04mL

2.41mL

1.20mL

24.08mL

4.82mL

2.41mL

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