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Chemical Structure| 202825-46-5 Chemical Structure| 202825-46-5

Structure of Safinamide mesylate
CAS No.: 202825-46-5

Chemical Structure| 202825-46-5

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Safinamide mesylate is mesylate salt of safinamide, selectively and reversibly inhibits MAO-B with IC50 of 98 nM, and exhibits 5918-fold selectivity against MAO-A.

Synonyms: FCE 26743 mesylate; EMD 1195686 mesylate; PNU-151774E

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Product Details of Safinamide mesylate

CAS No. :202825-46-5
Formula : C18H23FN2O5S
M.W : 398.45
SMILES Code : C[C@H](NCC1=CC=C(OCC2=CC=CC(F)=C2)C=C1)C(N)=O.CS(=O)(O)=O
Synonyms :
FCE 26743 mesylate; EMD 1195686 mesylate; PNU-151774E
MDL No. :MFCD15145475

Safety of Safinamide mesylate

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H301-H318-H400
Precautionary Statements:P273-P280-P301+P310-P305+P351+P338
Class:6.1
UN#:2811
Packing Group:

Isoform Comparison

Biological Activity

Description
Safinamide mesylate (FCE 26743; EMD 1195686) is a potent, selective, and reversible inhibitor of monoamine oxidase B (MAO-B), demonstrating an IC50 of 0.098 µM, significantly more selective over MAO-A with an IC50 of 580 nM[1].

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT00627640 Idiopathic Parkinson's Disease Phase 3 Completed - -
NCT00605683 Idiopathic Parkinson's Disease Phase 3 Completed - -
NCT03753763 Multiple System Atrophy Phase 2 Not yet recruiting March 31, 2020 -

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.51mL

0.50mL

0.25mL

12.55mL

2.51mL

1.25mL

25.10mL

5.02mL

2.51mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

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