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CAS No. :	121521-90-2
Formula :	C₃₆H₃₀O₁₆
M.W :	718.61
SMILES Code :	O=C(O)[C@H](OC([C@@H]1[C@@H](C2=CC=C(O)C(O)=C2)OC3=C(O)C=CC(/C=C/C(O[C@@H](C(O)=O)CC4=CC=C(O)C(O)=C4)=O)=C13)=O)CC5=CC=C(O)C(O)=C5
Synonyms :	Lithospermic acid B; Lithospermate B; Danfensuan B
MDL No. :	MFCD07779133

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H315-H319-H335
Precautionary Statements:	P261-P305+P351+P338

LO2 cells	0.05 to 20 μM	24 hours	Salvianolic acid B inhibited ferroptosis in LO2 cells by upregulating Ecm1, reducing ROS activity and lipid peroxidation damage, and upregulating xCT and Gpx4 protein expression.	PMC10808927
Human adipose-derived stem cells (h-ADSCs)	10, 50, 100 μM	24 hours	To evaluate the effect of salvianolic acid B on cell proliferation, results showed that appropriate concentrations of salvianolic acid B (10, 50 μmol/L) increased the proportion of EdU-positive cells.	PMC8447755
3T3-L1 cells	10, 50, 100 μM	24 hours	To evaluate the effect of salvianolic acid B on cell proliferation, results showed that appropriate concentrations of salvianolic acid B (10, 50 μmol/L) increased the proportion of EdU-positive cells.	PMC8447755
H9c2 cells	40 and 80 µM	24 hours	Sal B inhibited glucose deprivation-induced apoptosis in H9c2 cells by reducing Bax expression and increasing Bcl-2 expression.	PMC10685573
Neonatal rat cardiac fibroblasts	12.5–50 µM	24 hours	Inhibited high glucose-induced proliferation, migration, phenotypic transformation, and collagen secretion in cardiac fibroblasts	PMC10712074
Oligodendrocyte precursor cells	20 µg/mL	3 days	Promoted the differentiation of oligodendrocyte precursor cells, with the most effective dose being 20 µg/mL.	PMC4829017
Human adipose-derived stem cells (h-ADSCs)	10, 50, 100 μM	4 and 8 days	To evaluate the effect of salvianolic acid B on adipogenic differentiation, results showed that salvianolic acid B promoted adipogenic differentiation, with 50 μmol/L showing the most obvious effect.	PMC8447755
3T3-L1 cells	10, 50, 100 μM	4 and 8 days	To evaluate the effect of salvianolic acid B on adipogenic differentiation, results showed that salvianolic acid B promoted adipogenic differentiation, with 50 μmol/L showing the most obvious effect.	PMC8447755
NIH-3T3 mouse embryonic fibroblasts	50 μg/ml	48 hours	To detect the effect of Sal B-DPI on TGF-β1-induced expression of fibrosis-related factors in NIH-3T3 cells, results showed Sal B-DPI significantly reduced the expression of fibrosis-related factors.	PMC9237582
NIH-3T3 mouse embryonic fibroblasts	50 μg/ml	48 hours	To detect the effect of Sal B-DPI on TGF-β1-induced NIH-3T3 cell migration, results showed Sal B-DPI significantly inhibited cell migration.	PMC9237582
NIH-3T3 mouse embryonic fibroblasts	25, 50 and 125 μg/ml	48 hours	To detect the effect of Sal B-DPI on TGF-β1-induced collagen deposition in NIH-3T3 cells, results showed Sal B-DPI (>50 μg/ml) significantly inhibited collagen content.	PMC9237582
NIH-3T3 mouse embryonic fibroblasts	25, 50, 100, 125, 150, 175 and 200 μg/ml	48 hours	To verify the effect of Sal B-DPI on NIH-3T3 cell proliferation, results showed Sal B-DPI (<125 μg/ml) had no significant effect on cell viability.	PMC9237582
Human HSC-LX2 cells	40 μM	48 hours	Inhibited the expression of HSC activation markers α-SMA and Collagen I	PMC10203340
SH-SY5Y-APP751 cells	10 μM	48 hours	Reduced BACE1 expression and Golgi sorting, decreased Aβ generation	PMC10618533
HUVECs cells	80 µM	6 hours	Sal B promoted tube formation and migration in HUVECs and increased the expressions of VEGF and PDGF.	PMC10685573
Human adipose-derived stem cells (h-ADSCs)	10, 50, 100 μM	72 hours	To explore the effect of salvianolic acid B on cell viability, results showed that appropriate concentrations of salvianolic acid B (less than 100 μmol/L) did not reduce cell viability and may increase cell proliferation in the range of 10 to 75 μmol/L.	PMC8447755
3T3-L1 cells	10, 50, 100 μM	72 hours	To explore the effect of salvianolic acid B on cell viability, results showed that appropriate concentrations of salvianolic acid B (less than 100 μmol/L) did not reduce cell viability and may increase cell proliferation in the range of 10 to 75 μmol/L.	PMC8447755

Zebrafish larvae	Wild-type AB zebrafish larvae and transgenic tg(sp7:egfp) zebrafish larvae	Exposure in water solution	0.2–2 μM	Half medium replaced daily for 6 days	To evaluate the protective effects of Sal B on osteogenesis in dexamethasone-treated larval zebrafish, results showed that Sal B stimulates bone formation and rescues GC-caused inhibition on osteogenesis by counteracting oxidative stress and increasing the expression of osteoblast-specific genes.	PMC5057235
ICR mice	Isoproterenol-induced myocardial ischemia model	Intraperitoneal injection	10 mg/kg	Once daily for 7 days	Sal B inhibited cardiomyocyte apoptosis and promoted angiogenesis by regulating autophagy, thereby improving myocardial ischemia.	PMC10685573
Sprague-Dawley rats	Bleomycin-induced pulmonary fibrosis model	Pulmonary administration	10 mg/kg (measured as Sal B)	Once daily for 28 days	To evaluate the therapeutic effect of Sal B-DPI on bleomycin-induced pulmonary fibrosis in rats, results showed Sal B-DPI significantly improved lung function and reduced inflammation and fibrosis.	PMC9237582
C57BL/6J mice	Subarachnoid hemorrhage model	Intraperitoneal injection	10 mg/kg, 20 mg/kg, 40 mg/kg	Starting 1 h after SAH, every 24 h for 3 days	SalB ameliorated SAH-induced functional deficits, significantly mitigated microglial activation, pro-inflammatory cytokines release, and neuronal injury. Mechanistically, SalB inhibited NLRP3 inflammasome activation and increased SIRT1 expression.	PMC10410262
Nude mice	Coleman fat graft model	Local injection	10, 50 μM	Once every 2 days for 4 weeks	To evaluate the effect of salvianolic acid B on fat graft survival, results showed that salvianolic acid B improved the survival rate of fat grafts, with 50 μmol/L showing the most significant effect.	PMC8447755
C57BL/6 mice	DSS-induced colitis model	Intragastric	100 mg/kg	Once daily for six consecutive days	Sal B enhanced TJ barrier function by down-regulating MLCK and up-regulating occludin, significantly reducing IL-1β-induced colitis recurrence rate	PMC7339324
Sprague-Dawley rats	Spinal cord injury model	Intraperitoneal injection	20 mg/kg	Once a day for 8 weeks	Promoted remyelination and recovery of neurological function after spinal cord injury, and reduced caspase-3 expression.	PMC4829017
5×FAD transgenic mice	Early-stage Alzheimer’s disease model	Intragastric administration	20 mg/kg/day	Once daily for 3 months	Ameliorated retinal functional and structural deficits, reduced Aβ plaque deposition and microglial activation	PMC10618533
Mice	Allergic asthma model	Intraperitoneal injection	20 μM	Injected 2 hours before each challenge, for 3 days	To investigate the protective effect of Salvianolic acid B on allergic airway inflammation. Results showed that SAB treatment significantly attenuated airway inflammation, mucus secretion, and collagen deposition.	PMC10334828
C57BL/6 male mice	CCl4-induced liver fibrosis model	Intraperitoneal injection	30 mg/kg/day	Once daily for 4 weeks	Significantly alleviated hepatic fibrogenesis by inhibiting HSC activation and collagen deposition	PMC10203340
Male C57BL/6J mice	Unilateral ureteral obstruction (UUO) and folic acid (FA)-induced renal fibrosis models	Tail vein injection	40 mg/kg	Once daily for 10 days	To evaluate the protective effects of salvianolic acid B against renal fibrosis. Results showed that salvianolic acid B significantly attenuated UUO-induced renal injury and fibrosis, inhibited EMT, inflammatory cytokine production, and collagen deposition.	PMC10043283
C57BL/6 mice	CCl4-induced liver fibrosis model	Intragastric administration	5.6 mg/kg, 11.2 mg/kg, 22.4 mg/kg	Once daily for 3 weeks	Salvianolic acid B significantly attenuated CCl4-induced liver fibrosis in mice by upregulating Ecm1 and inhibiting hepatocyte ferroptosis.	PMC10808927
C57BL/6J mice	Diabetic cardiomyopathy model	Gavage	Low-dose group 1.5 mg/kg/day, high-dose group 3 mg/kg/day	6 days/week for 8 weeks	Improved cardiac function, inhibited collagen deposition and phenotypic transformation, and ameliorated myocardial fibrosis in DCM mice by upregulating Smad7	PMC10712074

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CAS No.: 121521-90-2

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CAS No.: 121521-90-2

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NCT01761227	Vascular Dementia	Phase 2	Completed	-	China, Beijing ... More >> Dongzhimen Hospital ,Beijing University of Chinese Medicine Beijing, Beijing, China, 100700 Less <<
NCT03306550	Angina, Stable	Not Applicable	Not yet recruiting	October 10, 2018	-

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed