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CAS No. :	5578-73-4
Formula :	C₂₀H₁₄ClNO₄
M.W :	367.78
SMILES Code :	C[N+]1=CC2=C3C(OCO3)=CC=C2C(C=CC4=C5)=C1C4=CC6=C5OCO6.[Cl-]
Synonyms :	Sanguinarin chloride; Sanguinarium chloride; Sanguinarine (chloride)
MDL No. :	MFCD00012126
InChI Key :	GIZKAXHWLRYMLE-UHFFFAOYSA-M
Pubchem ID :	68635

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302
Precautionary Statements:	P280-P305+P351+P338

16HBE	1 µM, 5 µM	48 hours	Assessed toxicity to normal cells	Transl Oncol. 2022 Mar;17:101345.
HT-115	3 µM		Induces cell death	Cell Death Discov. 2023 Mar 13;9(1):94.
HCT-116	3 µM		Induces cell death	Cell Death Discov. 2023 Mar 13;9(1):94.
MDA-MB-231	1 µM	14 days	SC significantly reduced the number of colonies formed by MDA-MB-231 cells in soft agar.	Cells. 2022 Apr 28;11(9):1485.
Mouse mammary epithelial cells (mMECs)	5, 25, 50 µM	1-hour pretreatment followed by 6-hours LPS stimulation	To evaluate the protective effect of SG against LPS-induced oxidative stress. Results showed that SG significantly inhibited LPS-induced ROS increase and enhanced the activities of antioxidant enzymes (SOD and GSH-Px).	Cells. 2022 Nov 18;11(22):3658.
MDA-MB-468 cells	1.5 µM	24 hours	To evaluate the effect of sanguinarine chloride on the viability of TNF-α-activated TNBC cells. Results showed that sanguinarine chloride significantly inhibited the viability of MDA-MB-468 cells with an IC50 value of 2.97 µM.	Int J Mol Sci. 2022 Jul 28;23(15):8329.
MDA-MB-231 cells	2 µM	24 hours	To evaluate the effect of sanguinarine chloride on the viability of TNF-α-activated TNBC cells. Results showed that sanguinarine chloride significantly inhibited the viability of MDA-MB-231 cells with an IC50 value of 3.11 µM.	Int J Mol Sci. 2022 Jul 28;23(15):8329.
NCI-H1688	30 µM, 10 µM, 5 µM, 1 µM	24 hours, 48 hours, 72 hours	Inhibited SCLC cell proliferation, colony formation, cell cycle, migration and invasion, and promoted apoptosis	Transl Oncol. 2022 Mar;17:101345.
Prostate cancer cells (LNCaP, VCaP, 22RV1, PC3, DU145)	0.5, 1.0 µM	24, 48 hours	To evaluate the effects of S.C on the viability and migration ability of prostate cancer cells. The results showed that S.C significantly inhibited the viability, clonogenicity, and migration ability of prostate cancer cells.	Chin Med. 2024 Jan 9;19(1):7.
HEK293T cells	1 µM	4 days	To evaluate the effect of sanguinarine on the proliferation of Rac1b cells, results showed that sanguinarine significantly inhibited the proliferation of Rac1b cells, increased the level of cleaved PARP-89, and decreased both the level of cyclin-D1 and the percentage of BrdU positive cells.	Acta Pharmacol Sin. 2015 Feb;36(2):229-40.
HTC75	1 µM	48 hours	SC inhibited telomerase activity in a dose-dependent manner with an IC50 of 1.21 μM.	Cells. 2022 Apr 28;11(9):1485.
HEK293T	1 µM	48 hours	Screening for natural hTERT inhibitors, SC significantly reduced GFP fluorescence intensity, indicating its inhibitory effect on hTERT expression.	Cells. 2022 Apr 28;11(9):1485.
HTC75 cells	1 µM	48 hours	Evaluate the inhibitory effect of SC on telomerase activity, results showed SC suppresses telomerase activity in a dose-dependent manner	Cells. 2022 Apr 28;11(9):1485.
LX-2 hepatic stellate cells	0.75 µM, 1.50 µM, 3.00 µM	48 hours	To evaluate the toxicity of sanguinarine chloride and its derivatives on normal hepatic stellate cells. The results showed that the toxicity of the sanguinarine chloride derivative was lower than that of sanguinarine chloride.	Int J Mol Sci. 2023 Apr 30;24(9):8113.
Human erythroleukemia cells (HEL cells)	0.75 µM, 1.50 µM, 3.00 µM	48 hours	To evaluate the inhibitory effect of sanguinarine chloride and its derivatives on the proliferation of HEL cells. The results showed that sanguinarine chloride and its derivatives significantly inhibited the proliferation of HEL cells in a dose-dependent manner.	Int J Mol Sci. 2023 Apr 30;24(9):8113.

Caenorhabditis elegans	Wild-type N2 and mutants	Administered via NGM agar plates	0.1, 0.2, 0.4 mM	Treatment started at L4 larval stage	Sanguinarine extends healthspan and enhances innate immunity via ROS-mediated PMK-1/SKN-1 pathway activation	iScience. 2022 Feb 4;25(3):103874
Sprague-Dawley rats	Chronic constriction injury (CCI) model	Intraperitoneal injection	1.00, 2.50 and 6.25 mg/kg	Once every two days	Sanguinarine chloride alleviates neuropathic pain by suppressing p38MAPK signaling and downregulating the expression of TNF-α, IL-1β, IL-6 and NF-κB activation.	Drug Des Devel Ther. 2020 Nov 4;14:4725-4733
Nude mice	MDA-MB-231 cell-derived xenograft model	Intravenous injection	1.1 μg/kg	Every 3 days for 24 days	Evaluate the anti-tumor efficacy of SC in vivo, results showed SC significantly inhibited tumor growth	Cells. 2022 Apr 28;11(9):1485.
BALB/C nude mice	NCI-H1688 xenograft model	Intraperitoneal injection	2.5 mg/kg	Every three days for three weeks	Evaluated the anti-tumor effect of Sanguinarine chloride on SCLC in vivo	Transl Oncol. 2022 Mar;17:101345.
NCG mice	DU145 xenograft model	Intraperitoneal injection	2.5 mg/kg and 5.0 mg/kg	Every two days, total seven times	Evaluate the inhibitory effect of S.C on prostate tumor growth, results showed S.C significantly inhibited tumor growth	Chin Med. 2024 Jan 9;19(1):7.
C57BL/6J mice	Destabilization of medial meniscus (DMM)-induced osteoarthritis model	Intraarticular injection	5 μM	Every 5 days for 8 weeks	To evaluate the protective effect of Sanguinarine chloride (SC) on DMM-induced osteoarthritis, results showed that SC significantly alleviated the severity of osteoarthritis.	JCI Insight. 2023 Feb 8;8(3):e166688
BALB/c mice	LPS-induced mastitis model	Intraperitoneal injection	5, 25, 50 μM	Twice every six hours	To evaluate the protective effect of SG against LPS-induced mastitis. Results showed that SG significantly alleviated mammary tissue congestion, inflammatory cell infiltration, and acinar structure destruction, reduced TNF-α and IL-1β expression, decreased MPO activity, and enhanced the integrity of the blood–milk barrier.	Cells. 2022 Nov 18;11(22):3658.
NCr nude mice	HT-29 xenograft model	Intraperitoneal injection	6 mg/kg	Every 3 days for 24 days	Significantly suppresses tumor growth via oxeiptosis-associated features	Cell Death Discov. 2023 Mar 13;9(1):94.
Grass carp	High-fat diet-induced intestinal dysfunction model	Dietary administration	600 μg/kg and 1200 μg/kg	Three times a day for 56 days	Sanguinarine chloride enhanced the immunity of grass carp and alleviated the damage of the intestinal physical and immune barriers by regulating the MLCK and NF-κB signaling molecules. Furthermore, sanguinarine improved intestinal microbiota homeostasis by regulating the structure of the intestinal microbiota.	Antioxidants (Basel). 2023 Jun 29;12(7):1366

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CAS No.: 5578-73-4

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CAS No.: 5578-73-4

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Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed