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Chemical Structure| 1224844-38-5 Chemical Structure| 1224844-38-5

Structure of Sapanisertib
CAS No.: 1224844-38-5

Chemical Structure| 1224844-38-5

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Sapanisertib (INK-128; MLN0128; TAK-228) serves as an orally available ATP-dependent mTOR1/2 inhibitor, exhibiting an IC50 of 1 nM for mTOR kinase.

Synonyms: INK-128; TAK-228; MLN0128

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Product Details of Sapanisertib

CAS No. :1224844-38-5
Formula : C15H15N7O
M.W : 309.33
SMILES Code : NC1=C2C(N(C(C)C)N=C2C3=CC=C(OC(N)=N4)C4=C3)=NC=N1
Synonyms :
INK-128; TAK-228; MLN0128
MDL No. :MFCD22124893
InChI Key :GYLDXIAOMVERTK-UHFFFAOYSA-N
Pubchem ID :45375953

Safety of Sapanisertib

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Related Pathways of Sapanisertib

PI3K-AKT

Isoform Comparison

Biological Activity

Target
  • mTOR

    mTOR, Ki:1.4 nM

In Vitro:

Cell Line
Concentration Treated Time Description References
H460 2μM 24 or 48 h MLN0128 durably inhibited HIF1α and GLUT1 expression and reduced glucose metabolism. PMC4654699
BON cells 100 nM 48 h To evaluate the effect of Sapanisertib on TF expression, results showed that Sapanisertib significantly reduced TF mRNA and protein expression. PMC6345540
Human cutaneous melanoma cells (WM3311, WM2032, WM853–2, WM858) 40 nM 72 h To evaluate the cytotoxicity of Sapanisertib on human cutaneous melanoma cells, results showed reduced cell survival. PMC8914349
Canine MM cells (M1, M5, M2, M3, Jones) 40 nM 4 and 24 h To evaluate the inhibitory effect of Sapanisertib on the PI3K/mTOR signaling pathway, results showed reduced levels of p-AKT and p-S6. PMC8914349
A549 2μM 24 h MLN0128 significantly inhibited mTORC1 and mTORC2 signaling pathways and induced apoptosis. PMC4654699
SK-BR-3 0.2 μM 24 h To evaluate the effect of Sapanisertib in combination with Neratinib on downstream signaling pathways in HER2+ cells. Results showed that Sapanisertib combined with Neratinib significantly inhibited phosphorylation of 4E-BP1 and S6. PMC8075007
BT-474 0.2 μM 24 h To evaluate the effect of Sapanisertib in combination with Neratinib on downstream signaling pathways in HER2+ cells. Results showed that Sapanisertib combined with Neratinib significantly inhibited phosphorylation of 4E-BP1 and S6. PMC8075007
HCC-1954 0.2 μM 24 h To evaluate the effect of Sapanisertib in combination with Neratinib on downstream signaling pathways in HER2+ cells. Results showed that Sapanisertib combined with Neratinib significantly inhibited phosphorylation of 4E-BP1 and S6. PMC8075007
Bone marrow cells 0 nM, 25 nM, 50 nM, 100 nM 4 days To investigate the effect of INK128 on the accumulation of MDSCs, results showed that INK128 inhibited the accumulation of MDSCs. PMC7944919
BON cells 100 nM 48 h Sapanisertib inhibited mTOR signaling and suppressed TF levels. PMC6345540

In Vivo:

Species
Animal Model
Administration Dosage Frequency Description References
Mice SHH-driven medulloblastoma model Intraperitoneal injection 0.1 mg/kg or 0.2 mg/kg Daily or every other day until P35 To test the efficacy of combining Sapanisertib with Palbociclib, results showed that the combination significantly prolonged mouse survival and reduced recurrence during therapy. PMC8791615
Nude mice BON tumor model Oral gavage 3 mg/kg Every other day for 34 days To evaluate the effect of Sapanisertib on BON tumor growth, results showed that Sapanisertib significantly reduced tumor volume and TF protein expression. PMC6345540
Nude mice Canine MM xenograft model Oral 2.0 mg/Kg Every other day for 3 weeks To evaluate the tumor growth inhibitory effect of Sapanisertib on the canine MM xenograft model, results showed inhibited tumor growth. PMC8914349
Mice KL luc mice Intraperitoneal injection 1.0mg/kg Once daily for 5 days MLN0128 potently inhibited mTORC1 and mTORC2 signaling pathways and reduced glucose metabolism. PMC4654699
Mice Diabetic mice model Intraperitoneal injection 1 mg/kg Once daily for 45 days To investigate the effect of INK128 on wound healing in diabetic mice, results showed that INK128 promoted wound healing. PMC7944919
Nude mice Orthotopic neuroblastoma xenograft model Intraperitoneal injection 2 mg/kg Once daily for 28 days INK128 significantly inhibited tumor growth in the orthotopic neuroblastoma xenograft model PMC4593396
Nude mice BON tumor model Oral gavage 3 mg/kg Every other day for 35 days Sapanisertib significantly reduced TF protein and co-factor activity in BON tumors, and the tumors were smaller compared to those in control mice. PMC6345540

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT02244463 Anaplastic Thyroid Cancer|Thyr... More >>oid Cancer|Differentiated Thyroid Cancer Less << PHASE1|PHASE2 COMPLETED 2022-04-28 Hoag Memorial Hospital Presbyt... More >>erian, Newport Beach, California, 92663, United States|Dana-Farber Cancer Institute, Boston, Massachusetts, 02115, United States|University of Michigan Medical School, Ann Arbor, Michigan, 48109, United States Less <<
NCT03047213 Locally Advanced Bladder Uroth... More >>elial Carcinoma|Metastatic Transitional Cell Carcinoma|Metastatic Urothelial Carcinoma|Recurrent Bladder Carcinoma|Stage III Bladder Urothelial Carcinoma AJCC v6 and v7|Stage IV Bladder Urothelial Carcinoma AJCC v7 Less << PHASE2 ACTIVE_NOT_RECRUITING 2025-11-11 Los Angeles General Medical Ce... More >>nter, Los Angeles, California, 90033, United States|USC / Norris Comprehensive Cancer Center, Los Angeles, California, 90033, United States|Keck Medical Center of USC Pasadena, Pasadena, California, 91105, United States|University of California Davis Comprehensive Cancer Center, Sacramento, California, 95817, United States|Smilow Cancer Center/Yale-New Haven Hospital, New Haven, Connecticut, 06510, United States|Yale University, New Haven, Connecticut, 06520, United States|Northwestern University, Chicago, Illinois, 60611, United States|University of Kansas Clinical Research Center, Fairway, Kansas, 66205, United States|Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore, Maryland, 21287, United States|Brigham and Women's Hospital, Boston, Massachusetts, 02115, United States|Dana-Farber Cancer Institute, Boston, Massachusetts, 02215, United States|University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan, 48109, United States|Nebraska Medicine-Bellevue, Bellevue, Nebraska, 68123, United States|Nebraska Medicine-Village Pointe, Omaha, Nebraska, 68118, United States|University of Nebraska Medical Center, Omaha, Nebraska, 68198, United States|UNC Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina, 27599, United States|University of Pittsburgh Cancer Institute (UPCI), Pittsburgh, Pennsylvania, 15232, United States|Vanderbilt Breast Center at One Hundred Oaks, Nashville, Tennessee, 37204, United States|Vanderbilt University/Ingram Cancer Center, Nashville, Tennessee, 37232, United States|Huntsman Cancer Institute/University of Utah, Salt Lake City, Utah, 84112, United States Less <<
NCT02091531 Metastatic Castration-Resistan... More >>t Prostate Cancer Less << PHASE2 COMPLETED 2025-10-18 Memorial Sloan Kettering Cance... More >>r Center, New York, New York, 10065, United States Less <<
NCT03370302 Advanced Nonhematological Neop... More >>lasms Less << PHASE1 TERMINATED 2019-08-28 National Cancer Center Hospita... More >>l East, Kashiwa-shi, Chiba-Ken, 277-8577, Japan|National Cancer Center Hospital, Chuo-ku, Tokyo-To, 104-0045, Japan|Asan Medical Center, Seoul, 05505, Korea, Republic of|National Taiwan-University Hospital, Taipei, 100, Taiwan Less <<
NCT02893930 Pancreatic Neuroendocrine Tumo... More >>r G1|Pancreatic Neuroendocrine Tumor G2|Refractory Pancreatic Neuroendocrine Carcinoma Less << PHASE2 COMPLETED 2022-12-21 Mayo Clinic Hospital in Arizon... More >>a, Phoenix, Arizona, 85054, United States|Mayo Clinic in Arizona, Scottsdale, Arizona, 85259, United States|CHI Saint Vincent Cancer Center Hot Springs, Hot Springs, Arkansas, 71913, United States|PCR Oncology, Arroyo Grande, California, 93420, United States|Sutter Auburn Faith Hospital, Auburn, California, 95602, United States|Sutter Cancer Centers Radiation Oncology Services-Auburn, Auburn, California, 95603, United States|Alta Bates Summit Medical Center-Herrick Campus, Berkeley, California, 94704, United States|Mills-Peninsula Medical Center, Burlingame, California, 94010, United States|Sutter Cancer Centers Radiation Oncology Services-Cameron Park, Cameron Park, California, 95682, United States|Eden Hospital Medical Center, Castro Valley, California, 94546, United States|Sutter Davis Hospital, Davis, California, 95616, United States|Palo Alto Medical Foundation-Fremont, Fremont, California, 94538, United States|Cedars Sinai Medical Center, Los Angeles, California, 90048, United States|Memorial Medical Center, Modesto, California, 95355, United States|Palo Alto Medical Foundation-Camino Division, Mountain View, California, 94040, United States|Palo Alto Medical Foundation-Gynecologic Oncology, Mountain View, California, 94040, United States|Sutter Cancer Research Consortium, Novato, California, 94945, United States|Palo Alto Medical Foundation Health Care, Palo Alto, California, 94301, United States|Stanford Cancer Institute Palo Alto, Palo Alto, California, 94304, United States|Sutter Cancer Centers Radiation Oncology Services-Roseville, Roseville, California, 95661, United States|Sutter Roseville Medical Center, Roseville, California, 95661, United States|Sutter Medical Center Sacramento, Sacramento, California, 95816, United States|California Pacific Medical Center-Pacific Campus, San Francisco, California, 94115, United States|Palo Alto Medical Foundation-Santa Cruz, Santa Cruz, California, 95065, United States|Sutter Pacific Medical Foundation, Santa Rosa, California, 95403, United States|Palo Alto Medical Foundation-Sunnyvale, Sunnyvale, California, 94086, United States|Sutter Cancer Centers Radiation Oncology Services-Vacaville, Vacaville, California, 95687, United States|Sutter Solano Medical Center/Cancer Center, Vallejo, California, 94589, United States|University of Colorado Hospital, Aurora, Colorado, 80045, United States|Penrose-Saint Francis Healthcare, Colorado Springs, Colorado, 80907, United States|Rocky Mountain Cancer Centers-Penrose, Colorado Springs, Colorado, 80907, United States|UCHealth Memorial Hospital Central, Colorado Springs, Colorado, 80909, United States|Porter Adventist Hospital, Denver, Colorado, 80210, United States|Mercy Medical Center, Durango, Colorado, 81301, United States|Southwest Oncology PC, Durango, Colorado, 81301, United States|Poudre Valley Hospital, Fort Collins, Colorado, 80524, United States|Mountain Blue Cancer Care Center, Golden, Colorado, 80401, United States|Rocky Mountain Cancer Centers-Lakewood, Lakewood, Colorado, 80228, United States|Saint Anthony Hospital, Lakewood, Colorado, 80228, United States|Littleton Adventist Hospital, Littleton, Colorado, 80122, United States|Longmont United Hospital, Longmont, Colorado, 80501, United States|Rocky Mountain Cancer Centers-Longmont, Longmont, Colorado, 80501, United States|Parker Adventist Hospital, Parker, Colorado, 80138, United States|Rocky Mountain Cancer Centers-Parker, Parker, Colorado, 80138, United States|Saint Mary Corwin Medical Center, Pueblo, Colorado, 81004, United States|Rocky Mountain Cancer Centers - Pueblo, Pueblo, Colorado, 81008, United States|Rocky Mountain Cancer Centers-Thornton, Thornton, Colorado, 80260, United States|Middlesex Hospital, Middletown, Connecticut, 06457, United States|Pali Momi Medical Center, 'Aiea, Hawaii, 96701, United States|Queen's Cancer Center - Pearlridge, 'Aiea, Hawaii, 96701, United States|The Cancer Center of Hawaii-Pali Momi, 'Aiea, Hawaii, 96701, United States|Hawaii Cancer Care Inc - Waterfront Plaza, Honolulu, Hawaii, 96813, United States|Island Urology, Honolulu, Hawaii, 96813, United States|Queen's Cancer Cenrer - POB I, Honolulu, Hawaii, 96813, United States|Queen's Medical Center, Honolulu, Hawaii, 96813, United States|Straub Clinic and Hospital, Honolulu, Hawaii, 96813, United States|University of Hawaii Cancer Center, Honolulu, Hawaii, 96813, United States|Hawaii Cancer Care Inc-Liliha, Honolulu, Hawaii, 96817, United States|Kuakini Medical Center, Honolulu, Hawaii, 96817, United States|Queen's Cancer Center - Kuakini, Honolulu, Hawaii, 96817, United States|The Cancer Center of Hawaii-Liliha, Honolulu, Hawaii, 96817, United States|Kapiolani Medical Center for Women and Children, Honolulu, Hawaii, 96826, United States|Wilcox Memorial Hospital and Kauai Medical Clinic, Lihue, Hawaii, 96766, United States|Saint Alphonsus Cancer Care Center-Boise, Boise, Idaho, 83706, United States|Saint Alphonsus Cancer Care Center-Caldwell, Caldwell, Idaho, 83605, United States|Kootenai Health - Coeur d'Alene, Coeur d'Alene, Idaho, 83814, United States|Walter Knox Memorial Hospital, Emmett, Idaho, 83617, United States|Idaho Urologic Institute-Meridian, Meridian, Idaho, 83642, United States|Saint Alphonsus Medical Center-Nampa, Nampa, Idaho, 83686, United States|Kootenai Clinic Cancer Services - Post Falls, Post Falls, Idaho, 83854, United States|Kootenai Cancer Clinic, Sandpoint, Idaho, 83864, United States|Rush - Copley Medical Center, Aurora, Illinois, 60504, United States|Saint Joseph Medical Center, Bloomington, Illinois, 61701, United States|Illinois CancerCare-Bloomington, Bloomington, Illinois, 61704, United States|Illinois CancerCare-Canton, Canton, Illinois, 61520, United States|Memorial Hospital of Carbondale, Carbondale, Illinois, 62902, United States|SIH Cancer Institute, Carterville, Illinois, 62918, United States|Illinois CancerCare-Carthage, Carthage, Illinois, 62321, United States|Centralia Oncology Clinic, Centralia, Illinois, 62801, United States|Northwestern University, Chicago, Illinois, 60611, United States|Carle on Vermilion, Danville, Illinois, 61832, United States|Cancer Care Specialists of Illinois - Decatur, Decatur, Illinois, 62526, United States|Decatur Memorial Hospital, Decatur, Illinois, 62526, United States|Carle Physician Group-Effingham, Effingham, Illinois, 62401, United States|Crossroads Cancer Center, Effingham, Illinois, 62401, United States|Illinois CancerCare-Eureka, Eureka, Illinois, 61530, United States|Illinois CancerCare-Galesburg, Galesburg, Illinois, 61401, United States|Western Illinois Cancer Treatment Center, Galesburg, Illinois, 61401, United States|Northwestern Medicine Cancer Center Delnor, Geneva, Illinois, 60134, United States|Illinois CancerCare-Kewanee Clinic, Kewanee, Illinois, 61443, United States|Northwestern Medicine Lake Forest Hospital, Lake Forest, Illinois, 60045, United States|Illinois CancerCare-Macomb, Macomb, Illinois, 61455, United States|Carle Physician Group-Mattoon/Charleston, Mattoon, Illinois, 61938, United States|Good Samaritan Regional Health Center, Mount Vernon, Illinois, 62864, United States|Cancer Care Center of O'Fallon, O'Fallon, Illinois, 62269, United States|Illinois CancerCare-Ottawa Clinic, Ottawa, Illinois, 61350, United States|Illinois CancerCare-Pekin, Pekin, Illinois, 61554, United States|OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center, Pekin, Illinois, 61554, United States|Illinois CancerCare-Peoria, Peoria, Illinois, 61615, United States|OSF Saint Francis Radiation Oncology at Peoria Cancer Center, Peoria, Illinois, 61615, United States|Methodist Medical Center of Illinois, Peoria, Illinois, 61636, United States|OSF Saint Francis Medical Center, Peoria, Illinois, 61637, United States|Illinois CancerCare-Peru, Peru, Illinois, 61354, United States|Valley Radiation Oncology, Peru, Illinois, 61354, United States|Illinois CancerCare-Princeton, Princeton, Illinois, 61356, United States|Southern Illinois University School of Medicine, Springfield, Illinois, 62702, United States|Springfield Clinic, Springfield, Illinois, 62702, United States|Memorial Medical Center, Springfield, Illinois, 62781, United States|Southwest Illinois Health Services LLP, Swansea, Illinois, 62226, United States|Carle Cancer Center, Urbana, Illinois, 61801, United States|The Carle Foundation Hospital, Urbana, Illinois, 61801, United States|Northwestern Medicine Cancer Center Warrenville, Warrenville, Illinois, 60555, United States|Rush-Copley Healthcare Center, Yorkville, Illinois, 60560, United States|Deaconess Clinic Downtown, Evansville, Indiana, 47713, United States|Chancellor Center for Oncology, Newburgh, Indiana, 47630, United States|Reid Health, Richmond, Indiana, 47374, United States|Medical Oncology and Hematology Associates-West Des Moines, Clive, Iowa, 50325, United States|Mercy Cancer Center-West Lakes, Clive, Iowa, 50325, United States|Alegent Health Mercy Hospital, Council Bluffs, Iowa, 51503, United States|Greater Regional Medical Center, Creston, Iowa, 50801, United States|Mercy Medical Center - Des Moines, Des Moines, Iowa, 50314, United States|Mission Cancer and Blood - Laurel, Des Moines, Iowa, 50314, United States|Siouxland Regional Cancer Center, Sioux City, Iowa, 51101, United States|Mercy Medical Center-West Lakes, West Des Moines, Iowa, 50266, United States|Cancer Center of Kansas - Chanute, Chanute, Kansas, 66720, United States|Cancer Center of Kansas - Dodge City, Dodge City, Kansas, 67801, United States|Cancer Center of Kansas - El Dorado, El Dorado, Kansas, 67042, United States|Cancer Center of Kansas - Fort Scott, Fort Scott, Kansas, 66701, United States|Cancer Center of Kansas-Independence, Independence, Kansas, 67301, United States|Cancer Center of Kansas-Kingman, Kingman, Kansas, 67068, United States|Lawrence Memorial Hospital, Lawrence, Kansas, 66044, United States|Cancer Center of Kansas-Liberal, Liberal, Kansas, 67905, United States|Cancer Center of Kansas-Manhattan, Manhattan, Kansas, 66502, United States|Cancer Center of Kansas - McPherson, McPherson, Kansas, 67460, United States|Cancer Center of Kansas - Newton, Newton, Kansas, 67114, United States|Cancer Center of Kansas - Parsons, Parsons, Kansas, 67357, United States|Cancer Center of Kansas - Pratt, Pratt, Kansas, 67124, United States|Cancer Center of Kansas - Salina, Salina, Kansas, 67401, United States|Cancer Center of Kansas - Wellington, Wellington, Kansas, 67152, United States|Cancer Center of Kansas-Wichita Medical Arts Tower, Wichita, Kansas, 67208, United States|Ascension Via Christi Hospitals Wichita, Wichita, Kansas, 67214, United States|Cancer Center of Kansas - Wichita, Wichita, Kansas, 67214, United States|Cancer Center of Kansas - Winfield, Winfield, Kansas, 67156, United States|Flaget Memorial Hospital, Bardstown, Kentucky, 40004, United States|Commonwealth Cancer Center-Corbin, Corbin, Kentucky, 40701, United States|Saint Joseph Radiation Oncology Resource Center, Lexington, Kentucky, 40504, United States|Saint Joseph Hospital East, Lexington, Kentucky, 40509, United States|Saint Joseph London, London, Kentucky, 40741, United States|Jewish Hospital, Louisville, Kentucky, 40202, United States|Saints Mary and Elizabeth Hospital, Louisville, Kentucky, 40215, United States|UofL Health Medical Center Northeast, Louisville, Kentucky, 40245, United States|Jewish Hospital Medical Center South, Shepherdsville, Kentucky, 40165, United States|Mercy Medical Center, Springfield, Massachusetts, 01104, United States|Saint Joseph Mercy Hospital, Ann Arbor, Michigan, 48106, United States|University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan, 48109, United States|Saint Joseph Mercy Brighton, Brighton, Michigan, 48114, United States|Trinity Health IHA Medical Group Hematology Oncology - Brighton, Brighton, Michigan, 48114, United States|Saint Joseph Mercy Canton, Canton, Michigan, 48188, United States|Trinity Health IHA Medical Group Hematology Oncology - Canton, Canton, Michigan, 48188, United States|Caro Cancer Center, Caro, Michigan, 48723, United States|Saint Joseph Mercy Chelsea, Chelsea, Michigan, 48118, United States|Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital, Chelsea, Michigan, 48118, United States|Hematology Oncology Consultants-Clarkston, Clarkston, Michigan, 48346, United States|Newland Medical Associates-Clarkston, Clarkston, Michigan, 48346, United States|Beaumont Hospital - Dearborn, Dearborn, Michigan, 48124, United States|Wayne State University/Karmanos Cancer Institute, Detroit, Michigan, 48201, United States|Ascension Saint John Hospital, Detroit, Michigan, 48236, United States|Great Lakes Cancer Management Specialists-Doctors Park, East China Township, Michigan, 48054, United States|Weisberg Cancer Treatment Center, Farmington Hills, Michigan, 48334, United States|Genesee Cancer and Blood Disease Treatment Center, Flint, Michigan, 48503, United States|Genesee Hematology Oncology PC, Flint, Michigan, 48503, United States|Genesys Hurley Cancer Institute, Flint, Michigan, 48503, United States|Hurley Medical Center, Flint, Michigan, 48503, United States|Academic Hematology Oncology Specialists, Grosse Pointe Woods, Michigan, 48236, United States|Great Lakes Cancer Management Specialists-Van Elslander Cancer Center, Grosse Pointe Woods, Michigan, 48236, United States|Michigan Breast Specialists-Grosse Pointe Woods, Grosse Pointe Woods, Michigan, 48236, United States|Allegiance Health, Jackson, Michigan, 49201, United States|Sparrow Hospital, Lansing, Michigan, 48912, United States|Hope Cancer Clinic, Livonia, Michigan, 48154, United States|Trinity Health Saint Mary Mercy Livonia Hospital, Livonia, Michigan, 48154, United States|Great Lakes Cancer Management Specialists-Macomb Medical Campus, Macomb, Michigan, 48044, United States|Michigan Breast Specialists-Macomb Township, Macomb, Michigan, 48044, United States|Saint Mary's Oncology/Hematology Associates of Marlette, Marlette, Michigan, 48453, United States|Monroe Cancer Center, Monroe, Michigan, 48162, United States|21st Century Oncology-Pontiac, Pontiac, Michigan, 48341, United States|Hope Cancer Center, Pontiac, Michigan, 48341, United States|Newland Medical Associates-Pontiac, Pontiac, Michigan, 48341, United States|Saint Joseph Mercy Oakland, Pontiac, Michigan, 48341, United States|Huron Medical Center PC, Port Huron, Michigan, 48060, United States|Lake Huron Medical Center, Port Huron, Michigan, 48060, United States|Great Lakes Cancer Management Specialists-Rochester Hills, Rochester Hills, Michigan, 48309, United States|Ascension Saint Mary's Hospital, Saginaw, Michigan, 48601, United States|Oncology Hematology Associates of Saginaw Valley PC, Saginaw, Michigan, 48604, United States|Bhadresh Nayak MD PC-Sterling Heights, Sterling Heights, Michigan, 48312, United States|Ascension Saint Joseph Hospital, Tawas City, Michigan, 48764, United States|Advanced Breast Care Center PLLC, Warren, Michigan, 48088, United States|Great Lakes Cancer Management Specialists-Macomb Professional Building, Warren, Michigan, 48093, United States|Macomb Hematology Oncology PC, Warren, Michigan, 48093, United States|Michigan Breast Specialists-Warren, Warren, Michigan, 48093, United States|Saint John Macomb-Oakland Hospital, Warren, Michigan, 48093, United States|Saint Mary's Oncology/Hematology Associates of West Branch, West Branch, Michigan, 48661, United States|Huron Gastroenterology PC, Ypsilanti, Michigan, 48106, United States|Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus, Ypsilanti, Michigan, 48197, United States|Sanford Joe Lueken Cancer Center, Bemidji, Minnesota, 56601, United States|Essentia Health Saint Joseph's Medical Center, Brainerd, Minnesota, 56401, United States|Fairview Ridges Hospital, Burnsville, Minnesota, 55337, United States|Mercy Hospital, Coon Rapids, Minnesota, 55433, United States|Essentia Health - Deer River Clinic, Deer River, Minnesota, 56636, United States|Essentia Health Saint Mary's - Detroit Lakes Clinic, Detroit Lakes, Minnesota, 56501, United States|Essentia Health Cancer Center, Duluth, Minnesota, 55805, United States|Essentia Health Saint Mary's Medical Center, Duluth, Minnesota, 55805, United States|Miller-Dwan Hospital, Duluth, Minnesota, 55805, United States|Fairview Southdale Hospital, Edina, Minnesota, 55435, United States|Lake Region Healthcare Corporation-Cancer Care, Fergus Falls, Minnesota, 56537, United States|Essentia Health - Fosston, Fosston, Minnesota, 56542, United States|Unity Hospital, Fridley, Minnesota, 55432, United States|Essentia Health Hibbing Clinic, Hibbing, Minnesota, 55746, United States|Fairview Clinics and Surgery Center Maple Grove, Maple Grove, Minnesota, 55369, United States|Minnesota Oncology Hematology PA-Maplewood, Maplewood, Minnesota, 55109, United States|Saint John's Hospital - Healtheast, Maplewood, Minnesota, 55109, United States|Abbott-Northwestern Hospital, Minneapolis, Minnesota, 55407, United States|Hennepin County Medical Center, Minneapolis, Minnesota, 55415, United States|Health Partners Inc, Minneapolis, Minnesota, 55454, United States|Monticello Cancer Center, Monticello, Minnesota, 55362, United States|New Ulm Medical Center, New Ulm, Minnesota, 56073, United States|Essentia Health - Park Rapids, Park Rapids, Minnesota, 56470, United States|North Memorial Medical Health Center, Robbinsdale, Minnesota, 55422, United States|Mayo Clinic in Rochester, Rochester, Minnesota, 55905, United States|Park Nicollet Clinic - Saint Louis Park, Saint Louis Park, Minnesota, 55416, United States|Regions Hospital, Saint Paul, Minnesota, 55101, United States|United Hospital, Saint Paul, Minnesota, 55102, United States|Essentia Health Sandstone, Sandstone, Minnesota, 55072, United States|Saint Francis Regional Medical Center, Shakopee, Minnesota, 55379, United States|Lakeview Hospital, Stillwater, Minnesota, 55082, United States|Sanford Thief River Falls Medical Center, Thief River Falls, Minnesota, 56701, United States|Essentia Health Virginia Clinic, Virginia, Minnesota, 55792, United States|Ridgeview Medical Center, Waconia, Minnesota, 55387, United States|Rice Memorial Hospital, Willmar, Minnesota, 56201, United States|Minnesota Oncology Hematology PA-Woodbury, Woodbury, Minnesota, 55125, United States|Sanford Cancer Center Worthington, Worthington, Minnesota, 56187, United States|Fairview Lakes Medical Center, Wyoming, Minnesota, 55092, United States|Saint Louis Cancer and Breast Institute-Ballwin, Ballwin, Missouri, 63011, United States|Central Care Cancer Center - Bolivar, Bolivar, Missouri, 65613, United States|Parkland Health Center-Bonne Terre, Bonne Terre, Missouri, 63628, United States|Cox Cancer Center Branson, Branson, Missouri, 65616, United States|Saint Francis Medical Center, Cape Girardeau, Missouri, 63703, United States|Southeast Cancer Center, Cape Girardeau, Missouri, 63703, United States|Capital Region Southwest Campus, Jefferson City, Missouri, 65109, United States|Freeman Health System, Joplin, Missouri, 64804, United States|Mercy Hospital Joplin, Joplin, Missouri, 64804, United States|Delbert Day Cancer Institute at PCRMC, Rolla, Missouri, 65401, United States|Mercy Clinic-Rolla-Cancer and Hematology, Rolla, Missouri, 65401, United States|Heartland Regional Medical Center, Saint Joseph, Missouri, 64506, United States|Saint Louis Cancer and Breast Institute-South City, Saint Louis, Missouri, 63109, United States|Missouri Baptist Medical Center, Saint Louis, Missouri, 63131, United States|Mercy Hospital Saint Louis, Saint Louis, Missouri, 63141, United States|Sainte Genevieve County Memorial Hospital, Sainte Genevieve, Missouri, 63670, United States|Mercy Hospital Springfield, Springfield, Missouri, 65804, United States|CoxHealth South Hospital, Springfield, Missouri, 65807, United States|Missouri Baptist Sullivan Hospital, Sullivan, Missouri, 63080, United States|Missouri Baptist Outpatient Center-Sunset Hills, Sunset Hills, Missouri, 63127, United States|Mercy Hospital Washington, Washington, Missouri, 63090, United States|Community Hospital of Anaconda, Anaconda, Montana, 59711, United States|Billings Clinic Cancer Center, Billings, Montana, 59101, United States|Bozeman Deaconess Hospital, Bozeman, Montana, 59715, United States|Benefis Healthcare- Sletten Cancer Institute, Great Falls, Montana, 59405, United States|Great Falls Clinic, Great Falls, Montana, 59405, United States|Saint Peter's Community Hospital, Helena, Montana, 59601, United States|Kalispell Regional Medical Center, Kalispell, Montana, 59901, United States|Community Medical Hospital, Missoula, Montana, 59804, United States|CHI Health Saint Francis, Grand Island, Nebraska, 68803, United States|Heartland Hematology and Oncology, Kearney, Nebraska, 68845, United States|CHI Health Good Samaritan, Kearney, Nebraska, 68847, United States|Saint Elizabeth Regional Medical Center, Lincoln, Nebraska, 68510, United States|Alegent Health Immanuel Medical Center, Omaha, Nebraska, 68122, United States|Hematology and Oncology Consultants PC, Omaha, Nebraska, 68122, United States|Alegent Health Bergan Mercy Medical Center, Omaha, Nebraska, 68124, United States|Alegent Health Lakeside Hospital, Omaha, Nebraska, 68130, United States|Creighton University Medical Center, Omaha, Nebraska, 68131, United States|Midlands Community Hospital, Papillion, Nebraska, 68046, United States|Carson Tahoe Regional Medical Center, Carson City, Nevada, 89703, United States|Cancer and Blood Specialists-Henderson, Henderson, Nevada, 89052, United States|Comprehensive Cancer Centers of Nevada - Henderson, Henderson, Nevada, 89052, United States|Comprehensive Cancer Centers of Nevada-Horizon Ridge, Henderson, Nevada, 89052, United States|Las Vegas Cancer Center-Henderson, Henderson, Nevada, 89052, United States|OptumCare Cancer Care at Seven Hills, Henderson, Nevada, 89052, United States|Comprehensive Cancer Centers of Nevada-Southeast Henderson, Henderson, Nevada, 89074, United States|GenesisCare USA - Henderson, Henderson, Nevada, 89074, United States|Desert West Surgery, Las Vegas, Nevada, 89102, United States|OptumCare Cancer Care at Charleston, Las Vegas, Nevada, 89102, United States|University Medical Center of Southern Nevada, Las Vegas, Nevada, 89102, United States|Cancer and Blood Specialists-Shadow, Las Vegas, Nevada, 89106, United States|Radiation Oncology Centers of Nevada Central, Las Vegas, Nevada, 89106, United States|GenesisCare USA - Las Vegas, Las Vegas, Nevada, 89109, United States|HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway, Las Vegas, Nevada, 89109, United States|HealthCare Partners Medical Group Oncology/Hematology-San Martin, Las Vegas, Nevada, 89113, United States|Radiation Oncology Centers of Nevada Southeast, Las Vegas, Nevada, 89119, United States|Cancer Therapy and Integrative Medicine, Las Vegas, Nevada, 89121, United States|Ann M Wierman MD LTD, Las Vegas, Nevada, 89128, United States|Cancer and Blood Specialists-Tenaya, Las Vegas, Nevada, 89128, United States|Comprehensive Cancer Centers of Nevada - Northwest, Las Vegas, Nevada, 89128, United States|GenesisCare USA - Vegas Tenaya, Las Vegas, Nevada, 89128, United States|HealthCare Partners Medical Group Oncology/Hematology-Tenaya, Las Vegas, Nevada, 89128, United States|OptumCare Cancer Care at MountainView, Las Vegas, Nevada, 89128, United States|Comprehensive Cancer Centers of Nevada-Summerlin, Las Vegas, Nevada, 89144, United States|Summerlin Hospital Medical Center, Las Vegas, Nevada, 89144, United States|Las Vegas Cancer Center-Medical Center, Las Vegas, Nevada, 89148-2405, United States|Comprehensive Cancer Centers of Nevada, Las Vegas, Nevada, 89148, United States|GenesisCare USA - Fort Apache, Las Vegas, Nevada, 89148, United States|OptumCare Cancer Care at Fort Apache, Las Vegas, Nevada, 89148, United States|HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills, Las Vegas, Nevada, 89149, United States|Comprehensive Cancer Centers of Nevada - Central Valley, Las Vegas, Nevada, 89169, United States|University Cancer Center, Las Vegas, Nevada, 89169, United States|Hope Cancer Care of Nevada-Pahrump, Pahrump, Nevada, 89048, United States|Renown Regional Medical Center, Reno, Nevada, 89502, United States|Saint Mary's Regional Medical Center, Reno, Nevada, 89503, United States|Radiation Oncology Associates, Reno, Nevada, 89509, United States|Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey, 08903, United States|Montefiore Medical Center-Einstein Campus, Bronx, New York, 10461, United States|Montefiore Medical Center-Weiler Hospital, Bronx, New York, 10461, United States|Montefiore Medical Center - Moses Campus, Bronx, New York, 10467, United States|Mount Sinai Hospital, New York, New York, 10029, United States|University of Rochester, Rochester, New York, 14642, United States|Southeastern Medical Oncology Center-Clinton, Clinton, North Carolina, 28328, United States|Southeastern Medical Oncology Center-Goldsboro, Goldsboro, North Carolina, 27534, United States|Wayne Memorial Hospital, Goldsboro, North Carolina, 27534, United States|Onslow Memorial Hospital, Jacksonville, North Carolina, 28546, United States|Southeastern Medical Oncology Center-Jacksonville, Jacksonville, North Carolina, 28546, United States|Sanford Bismarck Medical Center, Bismarck, North Dakota, 58501, United States|Essentia Health Cancer Center-South University Clinic, Fargo, North Dakota, 58103, United States|Sanford South University Medical Center, Fargo, North Dakota, 58103, United States|Sanford Broadway Medical Center, Fargo, North Dakota, 58122, United States|Sanford Roger Maris Cancer Center, Fargo, North Dakota, 58122, United States|Essentia Health - Jamestown Clinic, Jamestown, North Dakota, 58401, United States|Indu and Raj Soin Medical Center, Beavercreek, Ohio, 45431, United States|Dayton Physicians LLC-Miami Valley South, Centerville, Ohio, 45459, United States|Miami Valley Hospital South, Centerville, Ohio, 45459, United States|Good Samaritan Hospital - Cincinnati, Cincinnati, Ohio, 45220, United States|Oncology Hematology Care Inc-Kenwood, Cincinnati, Ohio, 45236, United States|Bethesda North Hospital, Cincinnati, Ohio, 45242, United States|TriHealth Cancer Institute-Westside, Cincinnati, Ohio, 45247, United States|TriHealth Cancer Institute-Anderson, Cincinnati, Ohio, 45255, United States|Ohio State University Comprehensive Cancer Center, Columbus, Ohio, 43210, United States|Good Samaritan Hospital - Dayton, Dayton, Ohio, 45406, United States|Miami Valley Hospital, Dayton, Ohio, 45409, United States|Dayton Physician LLC-Miami Valley Hospital North, Dayton, Ohio, 45415, United States|Miami Valley Hospital North, Dayton, Ohio, 45415, United States|Armes Family Cancer Center, Findlay, Ohio, 45840, United States|Blanchard Valley Hospital, Findlay, Ohio, 45840, United States|Orion Cancer Care, Findlay, Ohio, 45840, United States|Atrium Medical Center-Middletown Regional Hospital, Franklin, Ohio, 45005-1066, United States|Dayton Physicians LLC-Atrium, Franklin, Ohio, 45005, United States|Dayton Physicians LLC-Wayne, Greenville, Ohio, 45331, United States|Wayne Hospital, Greenville, Ohio, 45331, United States|Greater Dayton Cancer Center, Kettering, Ohio, 45409, United States|First Dayton Cancer Care, Kettering, Ohio, 45420, United States|Kettering Medical Center, Kettering, Ohio, 45429, United States|Dayton Physicians LLC-Signal Point, Middletown, Ohio, 45042, United States|Dayton Physicians LLC-Wilson, Sidney, Ohio, 45365, United States|Springfield Regional Cancer Center, Springfield, Ohio, 45504, United States|Springfield Regional Medical Center, Springfield, Ohio, 45505, United States|ProMedica Flower Hospital, Sylvania, Ohio, 43560, United States|Dayton Physicians LLC-Upper Valley, Troy, Ohio, 45373, United States|Upper Valley Medical Center, Troy, Ohio, 45373, United States|Mercy Hospital Oklahoma City, Oklahoma City, Oklahoma, 73120, United States|Saint Alphonsus Medical Center-Baker City, Baker City, Oregon, 97814, United States|Saint Alphonsus Medical Center-Ontario, Ontario, Oregon, 97914, United States|Lehigh Valley Hospital-Cedar Crest, Allentown, Pennsylvania, 18103, United States|Lehigh Valley Hospital - Muhlenberg, Bethlehem, Pennsylvania, 18017, United States|Sanford Cancer Center Oncology Clinic, Sioux Falls, South Dakota, 57104, United States|Sanford USD Medical Center - Sioux Falls, Sioux Falls, South Dakota, 57117-5134, United States|Memorial Hospital, Chattanooga, Tennessee, 37404, United States|Pulmonary Medicine Center of Chattanooga-Hixson, Hixson, Tennessee, 37343, United States|Memorial GYN Plus, Ooltewah, Tennessee, 37363, United States|Saint Joseph Regional Cancer Center, Bryan, Texas, 77802, United States|Sovah Health Martinsville, Martinsville, Virginia, 24115, United States|Harrison HealthPartners Hematology and Oncology-Bremerton, Bremerton, Washington, 98310, United States|Harrison Medical Center, Bremerton, Washington, 98310, United States|Highline Medical Center-Main Campus, Burien, Washington, 98166, United States|Saint Elizabeth Hospital, Enumclaw, Washington, 98022, United States|Saint Francis Hospital, Federal Way, Washington, 98003, United States|Saint Clare Hospital, Lakewood, Washington, 98499, United States|Harrison HealthPartners Hematology and Oncology-Poulsbo, Poulsbo, Washington, 98370, United States|Franciscan Research Center-Northwest Medical Plaza, Tacoma, Washington, 98405, United States|Northwest Medical Specialties PLLC, Tacoma, Washington, 98405, United States|United Hospital Center, Bridgeport, West Virginia, 26330, United States|WVUH-Berkely Medical Center, Martinsburg, West Virginia, 25401, United States|West Virginia University Healthcare, Morgantown, West Virginia, 26506, United States|Camden Clark Medical Center, Parkersburg, West Virginia, 26101, United States|Duluth Clinic Ashland, Ashland, Wisconsin, 54806, United States|Northwest Wisconsin Cancer Center, Ashland, Wisconsin, 54806, United States|Marshfield Clinic-Chippewa Center, Chippewa Falls, Wisconsin, 54729, United States|Marshfield Medical Center-EC Cancer Center, Eau Claire, Wisconsin, 54701, United States|Marshfield Clinic - Ladysmith Center, Ladysmith, Wisconsin, 54848, United States|Marshfield Medical Center-Marshfield, Marshfield, Wisconsin, 54449, United States|Medical College of Wisconsin, Milwaukee, Wisconsin, 53226, United States|Marshfield Clinic-Minocqua Center, Minocqua, Wisconsin, 54548, United States|Cancer Center of Western Wisconsin, New Richmond, Wisconsin, 54017, United States|Marshfield Medical Center-Rice Lake, Rice Lake, Wisconsin, 54868, United States|Marshfield Medical Center-River Region at Stevens Point, Stevens Point, Wisconsin, 54482, United States|Marshfield Clinic-Wausau Center, Wausau, Wisconsin, 54401, United States|Marshfield Medical Center - Weston, Weston, Wisconsin, 54476, United States|Marshfield Clinic - Wisconsin Rapids Center, Wisconsin Rapids, Wisconsin, 54494, United States|Billings Clinic-Cody, Cody, Wyoming, 82414, United States|Welch Cancer Center, Sheridan, Wyoming, 82801, United States Less <<
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NCT02197572 Advanced Solid Tumors PHASE1 COMPLETED 2019-02-28 Sarasota, Florida, United Stat... More >>es|Saint Louis, Missouri, United States|Bronx, New York, United States|Oklahoma City, Oklahoma, United States|Dallas, Texas, United States Less <<
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Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.23mL

0.65mL

0.32mL

16.16mL

3.23mL

1.62mL

32.33mL

6.47mL

3.23mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

References

 

Historical Records

Categories