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Chemical Structure| 218136-59-5 Chemical Structure| 218136-59-5

Structure of SC-26196
CAS No.: 218136-59-5

Chemical Structure| 218136-59-5

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SC-26196 is a selective Delta 6 desaturase inhibitor with IC50 = 0.2 μM. It had pharmacokinetic and pharmacodynamic profiles in mice and showed antiinflammatory properties. It resulted in 36-37% fewer tumors in Apc(Min/+) mice and 35% decrease in primary tumor size in nude mice bearing HT-29 human colon cancer cell xenografts.

Synonyms: α,α-Diphenyl-4-[(3-pyridinylmethylene)amino]-1-piperazinepentanenitrile

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Product Details of SC-26196

CAS No. :218136-59-5
Formula : C27H29N5
M.W : 423.55
SMILES Code : N#CC(C1=CC=CC=C1)(C2=CC=CC=C2)CCCN3CCN(/N=C/C4=CC=CN=C4)CC3
Synonyms :
α,α-Diphenyl-4-[(3-pyridinylmethylene)amino]-1-piperazinepentanenitrile
MDL No. :MFCD11226148

Safety of SC-26196

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P280-P301+P312-P302+P352-P305+P351+P338

Isoform Comparison

Biological Activity

In Vitro:

Cell Line
Concentration Treated Time Description References
NCI-H295R cells 10 μM 18 hours Analyze mitochondrial lipidome and steroidogenesis Sci Adv. 2023 Jul 21;9(29):eadf6710
Jurkat T cell leukemia cells 200 nM 144 hours To investigate the effect of SC26196 on Jurkat cell proliferation. Results showed that SC26196 did not significantly alter Jurkat cell proliferation. Front Immunol. 2018 Mar 5;9:432
Primary adrenocortical cells 10 μM 18 hours Measure mitochondrial membrane potential and oxygen consumption rate Sci Adv. 2023 Jul 21;9(29):eadf6710

In Vivo:

Species
Animal Model
Administration Dosage Frequency Description References
Mice Aged mouse heart model Oral 100 mg/kg/d Once daily for 4 weeks Inhibition of delta-6 desaturase activity, reversal of cardiac phospholipid remodeling, and significant attenuation of cardiac dilatation, hypertrophy, and contractile dysfunction in aged mice J Gerontol A Biol Sci Med Sci. 2014 Jul;69(7):799-809

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.36mL

0.47mL

0.24mL

11.80mL

2.36mL

1.18mL

23.61mL

4.72mL

2.36mL

Dissolving Methods
The prepared working fluid is recommended to be prepared now and used up as soon as possible in a short period of time. The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1

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