Size	Price	VIP Price	US Stock	Global Stock	In Stock
{[ item.pr_size ]}		Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

CAS No. :	1216720-69-2
Formula :	C₂₃H₂₇Cl₂N₅
M.W :	444.40
SMILES Code :	NC1=C2C3=C(N(CC4=CC=C(C(C)C)C=C4)C=C3)C=CC2=NC(NC5CC5)=N1.[H]Cl.[H]Cl
Synonyms :	SCH 79797 (hydrochloride); SCH79797 dihydrochloride
MDL No. :	MFCD04039788

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H315-H319
Precautionary Statements:	P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

P815 mouse mast cells	1.0 µM	16 hours	To evaluate the effect of SCH79797 (PAR1 inhibitor) on thrombin-induced mediator secretion from P815 cells. Results showed that SCH79797 reduced the secretion of VEGF, TNF-α, CCL-2, CXCL-5, and CXCL-1 but had no significant effect on IL-2 and IL-6 secretion.	Mediators Inflamm. 2019 Nov 14;2019:4952131
Human cardiomyocytes	10 µM	16 hours	SCH79797 attenuated thrombin-induced COX-2 expression and PGE2 production by inhibiting PAR1-dependent signaling pathways.	Br J Pharmacol. 2014 Oct;171(19):4504-19
E. coli MJF455	1 µM	16-17 hours	Evaluate the effect of SCH-79797 on bacterial growth, showing MscL expression-dependent growth inhibition	Antibiotics (Basel). 2022 Jul 19;11(7):970
Neural stem cells (NSCs)	35 or 70 nM	18 hours	SCH79797 promoted BrdU incorporation in PAR1+/+ NSCs, increasing proliferation by 39%.	Sci Rep. 2018 Jun 19;8(1):9360
Human tracheal smooth muscle cells (HTSMCs)	10 µM	1-hour pretreatment	SCH79797 significantly inhibited thrombin-induced upregulation of COX-2 mRNA levels and promoter activity	Mediators Inflamm. 2022 Apr 19;2022:4600029
Human umbilical vein endothelial cells (HUVECs)	150 nM	1-hour pretreatment, followed by 90 min hourseat stress and 6 or 12 hours recovery period	To investigate the effect of SCH79797 on heat stress-induced apoptosis in HUVECs. Results showed that SCH79797 significantly reduced cell apoptosis, caspase-3 activity, and expression of pro-apoptotic protein Bax, while increasing expression of anti-apoptotic protein Mcl-1.	Mol Med Rep. 2017 May;15(5):2595-2603
S. aureus MRSA USA300	6.3 μg/mL	2 hours	To evaluate efficacy against persister cells, SCH-79797 effectively killed persister cells	Cell. 2020 Jun 25;181(7):1518-1532.e14.
Cardiac fibroblasts	1 µM	2.5 hours	Inhibited ERK1/2 phosphorylation induced by thrombin or FXa	J Am Heart Assoc. 2020 Jun 16;9(12):e015616
E. coli lptD4213	6.2 μg/mL	3 hours	To assess bactericidal activity of SCH-79797, results showed significant reduction in colony forming units	Cell. 2020 Jun 25;181(7):1518-1532.e14.
Human neutrophils	10 µM	3 hours	Enhanced neutrophil killing of E. coli by increasing NET formation	J Antimicrob Chemother. 2018 Jun 1;73(6):1586-1594
Mouse neutrophils	10 µM	3 hours	Enhanced neutrophil killing of E. coli by increasing ROS production, NET formation, and CRAMP release	J Antimicrob Chemother. 2018 Jun 1;73(6):1586-1594
HEK293 cells	0.3 or 1 µM	3, 6, or 24 hours	Assessed cytotoxicity and apoptosis effects of SCH79797, showing no significant impact	J Am Heart Assoc. 2020 Jun 16;9(12):e015616
A rat VSMC line (A10)	0.1 µM	30 min	Significantly blocked thrombin-induced CTGF expression	Acta Pharmacol Sin. 2012 Jan;33(1):49-56
Primary rat aortic smooth muscle cells (RASMCs)	0.1 µM	30 min	Significantly blocked thrombin-induced CTGF expression	Acta Pharmacol Sin. 2012 Jan;33(1):49-56
E. coli MJF455	5 µM	30 minutes	Assess the effect of SCH-79797 on MscL channel activity via patch clamp, showing significant increase in channel activity	Antibiotics (Basel). 2022 Jul 19;11(7):970
SW480 cells	100 µM	48 hours	Attenuated the proliferation, migration and invasion of KLK8-upregulated RKO and SW480 cells	Cell Death Dis. 2021 Sep 22;12(10):860
RKO cells	100 µM	48 hours	Attenuated the proliferation, migration and invasion of KLK8-upregulated RKO and SW480 cells	Cell Death Dis. 2021 Sep 22;12(10):860
Oligodendrocyte progenitor cells (OPCs)	70 nM	48 hours	Inhibited PLP and MBP expression, reduced NogoA RNA levels	Glia. 2015 May;63(5):846-59
Human platelets	3 µM	5 min	Block PAR1, inhibit platelet aggregation and intracellular calcium signaling	Proc Natl Acad Sci U S A. 2005 Jan 4;102(1):216-20

Rat	Intraventricular hemorrhage model	Intracerebroventricular injection	0.15 nmol	Single injection, euthanized after 24 hours	To evaluate the inhibitory effect of SCH79797 on thrombin-induced hydrocephalus. Results showed that SCH79797 significantly reduced thrombin-induced ventricular enlargement and ventricular wall damage.	J Cereb Blood Flow Metab. 2014 Mar;34(3):489-94
Mice	PAR1−/− and PAR1+/+ mice	Bilateral intra-amygdala injection	1 µM	Single injection, lasting 15 minutes	To investigate the effect of SCH79797 on fear memory, results showed that pharmacological inhibition of PAR1 enhanced fear memory.	Mol Psychiatry. 2013 Oct;18(10):1136-45
Neonatal rat pups	Germinal matrix hemorrhage model	Intraperitoneal injection	10 mg/kg	Twice a day for three days	To evaluate the effects of PAR-1 antagonist SCH79797 on long-term neurofunctional and brain morphological outcomes after germinal matrix hemorrhage. Results showed that SCH79797 alone did not significantly improve neurofunctional recovery or reduce ventricular dilation and white matter loss.	J Cereb Blood Flow Metab. 2017 Sep;37(9):3135-3149
Mice	E. coli pneumonia model	Intratracheal administration	10 μM	Single dose, observed after 6 hours	Significantly improved survival, reduced lung injury and inflammation, and enhanced bacterial clearance	J Antimicrob Chemother. 2018 Jun 1;73(6):1586-1594
BALB/c nude mice	Xenograft model and metastasis model	Intraperitoneal injection	25 µg/mg	Once daily for 25 days	Reduced the tumour volume of xenograft model and decreased the metastatic nodules in the livers of metastasis model	Cell Death Dis. 2021 Sep 22;12(10):860
C57BL/6J mice	Pilocarpine-induced status epilepticus model	Intraperitoneal injection	25 mg/kg	Single dose, observed for 24 hours	To evaluate the effect of SCH79797 on LTP in a pilocarpine-induced status epilepticus model, results showed that SCH79797 prevented the reduction of LTP	Front Cell Neurosci. 2022 May 24;16:900925
Adult male Wistar rats	Lithium-pilocarpine induced status epilepticus model	Intraperitoneal injection	25 μg/kg	Once daily for 10 consecutive days	To evaluate the effect of PAR1 inhibition on animal survival, neuronal survival, epileptiform activity, and behavioral seizures post-SE. Results showed that SCH79797 significantly reduced mortality, decreased neuronal loss, and suppressed epileptiform activity and behavioral seizures.	Neurobiol Dis. 2015 Jun;78:68-76
Sprague-Dawley rats	Subarachnoid hemorrhage model	Intraperitoneal injection	25 μg/kg	Assessed at 24 hours	SCH79797 significantly reduced brain edema, Evans blue extravasation, and neurobehavioral deficits, and decreased PAR-1 expression while maintaining VE-cadherin levels	Stroke. 2013 May;44(5):1410-7
Sprague Dawley rats	Myocardial ischemia/reperfusion injury model	Intravenous injection	25 μg/kg	Single dose, 15 minutes before ischemia or during ischemia	To evaluate the protective effect of SCH79797 in vivo on myocardial ischemia/reperfusion injury, results showed that 25 μg/kg IV dose significantly reduced infarct size.	Basic Res Cardiol. 2007 Jul;102(4):350-8
Sprague Dawley rats	Intraventricular thrombin-induced hydrocephalus model	Intraperitoneal injection	25 μg/kg	Immediate administration, lasting for 24 hours	Inhibition of PAR1 attenuated thrombin-induced hydrocephalus and reversed the downregulation of VE-cadherin	CNS Neurosci Ther. 2019 Oct;25(10):1142-1150
Japanese white rabbits	Transient global cerebral ischemia/reperfusion injury model induced by cardiac arrest	Intravenous injection	25 μg/kg	Administered 10 minutes after restoration of spontaneous circulation and again 24 hours later	SCH79797 mitigates brain injury via anti-inflammatory and anti-apoptotic effects, possibly by modulating the ERK, JNK/c-Jun and PI3K/Akt pathways.	Neural Regen Res. 2017 Feb;12(2):242-249
Rats	Trigeminal neuralgia model	Intraperitoneal injection	25 μg/kg	Once a week	SCH79797 effectively ameliorated orofacial mechanical allodynia in the trigeminal neuralgia model	Front Mol Neurosci. 2022 Dec 20;15:1059980
Mice	Renin-overexpressing hypertensive mouse model	Continuous subcutaneous infusion	25 μg/kg/day	For 4 weeks	SCH79797 significantly reduced cardiac hypertrophy and fibrosis in Ren-Tg mice, decreased monocyte/macrophage deposition, and downregulated the expression of inflammatory and fibrotic-related genes	J Am Heart Assoc. 2020 Jun 16;9(12):e015616
Rats	Gastric ulcer model	Oral	5 nmol	Twice daily for 1 week	Significantly retard gastric ulcer healing	Proc Natl Acad Sci U S A. 2005 Jan 4;102(1):216-20
Sprague-Dawley rats	Surgical brain injury model	Intraperitoneal injection	5 or 25 μg/kg	Single dose, evaluated after 24 hours	SCH79797 reduced SBI-induced brain edema and neurological deficits, and decreased apoptosis by inhibiting the PAR-1/Ask1/JNK pathway.	Neurobiol Dis. 2013 Feb;50:13-20
Sprague-Dawley rats	Spinal cord injury (SCI) model	Intrathecally	50 μg/kg	Single injection, observed for 21 days	To evaluate the effect of SCH79797 on motor function recovery after SCI, results showed SCH79797 significantly reduced microglia/macrophage migration and improved motor function.	Neural Regen Res. 2023 Jun;18(6):1339-1346
Galleria mellonella	G. mellonella infection model	Injection	67 μg/larva	Single dose, survival rate observed	To assess antibiotic activity in an animal model, results showed significant prolongation of survival in infected wax worms	Cell. 2020 Jun 25;181(7):1518-1532.e14.

{[proInfo.proName]}

CAS No.: 1216720-69-2

{[proInfo.proName]}

CAS No.: 1216720-69-2

Alternative Products

Product Details of SCH79797 2HCl

Safety of SCH79797 2HCl

Related Pathways of SCH79797 2HCl

Isoform Comparison

Biological Activity

Protocol

References

Historical Records

Categories

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

Molarity Calculator

Total Compounds Calculator

Dissolution Calculator

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed