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CAS No. :	92-61-5
Formula :	C₁₀H₈O₄
M.W :	192.17
SMILES Code :	COC1=C(O)C=C2OC(=O)C=CC2=C1
Synonyms :	Gelseminic acid; Chrysatropic acid; NSC 405647
MDL No. :	MFCD00006872
InChI Key :	RODXRVNMMDRFIK-UHFFFAOYSA-N
Pubchem ID :	5280460

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H315-H319-H335
Precautionary Statements:	P261-P305+P351+P338

CCRF-CEM	26.1 µM (IC50)	72 hours	Evaluate the cytotoxicity of Scopoletin on CCRF-CEM cells	Molecules. 2016 Apr 15;21(4):496
SCN second-stage juveniles (J2)	81.00 µg/mL, 40.50 µg/mL, 20.25 µg/mL, 4.05 µg/mL, 0.81 µg/mL	12, 24, 48, 72, and 96 hours	Evaluate the nematicidal activity of Scopoletin against SCN J2. High concentrations of Scopoletin (T1 and T2) showed significant effects on J2 poisoning, while lower concentrations (T4 and T5) had negligible effects.	Life (Basel). 2021 Oct 26;11(11):1143
HeLa cells	250 µM	15 minutes	To test the antioxidant capacity of Sp under oxidative stress conditions, results showed that Sp significantly reduced 3-AT-induced oxidative radicals and improved cell viability.	Cell Death Dis. 2020 Sep 10;11(9):739
Horseradish peroxidase (HRP)	1 µM	150 msec to 5 sec	Scopoletin rapidly reacts with HRP to form a stable, spectroscopically distinguishable form of the enzyme, inhibiting HRP's reactions with molecular oxygen and indole-3-acetic acid (IAA).	Plant Physiol. 1972 Jun;49(6):1012-8
Phakopsora pachyrhizi uredospores	500 µM	16 hours	Scopoletin inhibited the germination of Pp spores, and this inhibition was reversible.	Plant J. 2019 Aug;99(3):397-413
Bone marrow-derived dendritic cells (BM-DCs)	100 µM	18 hours	Scopoletin significantly inhibited the activation of BM-DCs, reducing the expression of MHC II, CD80, and CD86.	Front Pharmacol. 2019 Aug 2;10:863
Rheumatoid arthritis fibroblast-like synoviocytes (HFLS-RA)	20 µM	24 and 48 hours	To evaluate the inhibitory effect of Scopoletin on HFLS-RA cell migration. Results showed that Scopoletin significantly reduced single-cell migration but only slightly inhibited collective migration.	Front Pharmacol. 2022 Jul 25;13:946210
Rheumatoid arthritis fibroblast-like synoviocytes (HFLS-RA)	20 µM	24 and 48 hours	To evaluate the inhibitory effect of Scopoletin on HFLS-RA cell proliferation. Results showed that Scopoletin significantly inhibited HFLS-RA proliferation at 30 μM and onwards.	Front Pharmacol. 2022 Jul 25;13:946210
Rat insulinoma 5f (RIN5f) cells	100 µM	24 hours	To evaluate the protective effect of SPL on palmitate-induced ER stress. SPL reduced the phosphorylation levels of IRE1α, PERK, and ATF6α induced by palmitate, indicating that SPL effectively inhibited ER stress in RIN5f cells.	Cell Stress Chaperones. 2018 Sep;23(5):857-869
SHSY-5Y cells	250 µM	24 hours	To evaluate the protective effects of Sp against MPP+-induced mitochondrial dysfunction and oxidative stress, results showed that Sp restored mitochondrial function and reduced oxidative stress.	Cell Death Dis. 2020 Sep 10;11(9):739
HEK 293 cells	2 mM	24 hours	Luciferase reporter assay confirmed Scopoletin activates HIV-1 LTR via NF-κB pathway	Int J Mol Sci. 2023 Aug 10;24(16):12649
Spodoptera frugiperda Sf9 cells	0, 10, 50, 90 µM	24 hours	To investigate the effect of scopoletin on intracellular free calcium [Ca2+]i levels in Sf9 cells. Results showed that scopoletin significantly elevated the [Ca2+]i levels in a concentration-dependent manner.	Front Physiol. 2019 Mar 6;10:164
Rheumatoid arthritis fibroblast-like synoviocytes (HFLS-RA)	20 µM	24 hours	To evaluate the inhibitory effect of Scopoletin on HFLS-RA cell invasion. Results showed that Scopoletin reduced the number of invasive cells, but the inhibitory rate was approximately half that of umbelliferone.	Front Pharmacol. 2022 Jul 25;13:946210
FL83B hepatocytes	5 µM–25 µM (IC50)	24 hours	To investigate the effects of scopoletin on MG-induced insulin resistance, results showed that scopoletin promoted Akt phosphorylation, restored PPARγ expression, suppressed PTP1B expression, and promoted GLUT2 plasma translocation.	Molecules. 2015 Feb 9;20(2):2786-801
SH-SY5Y cells	5 µM	3 hours pretreatment followed by 24 hours exposure to H2O2	To evaluate the neuroprotective effects of scopoletin against H2O2-induced neuronal cell death. Results showed that scopoletin pretreatment significantly increased cell viability (95.1±4.7%), reduced apoptotic cell count (13.3±1.2%) and ROS levels (100.0±1.4%), and maintained the expression levels of SIRT1, FoxO3a, ADAM10, BCL-2, and antioxidant enzymes (catalase and SOD2).	RSC Adv. 2020 Apr 27;10(28):16593-16606
Candida tropicalis ATCC 28707	50 mg/mL	48 hours	To evaluate the antifungal activity of scopoletin against a multidrug-resistant Candida tropicalis strain. Results showed scopoletin has a fungistatic effect, significantly reducing fungal growth curves and cell density (91.7% reduction).	Front Microbiol. 2020 Jul 7;11:1525
Raw 264.7 cells	1–20 µM	5 days	Scopoletin promoted the formation of TRAP-positive multinucleated osteoclasts and bone resorption, reversing the impairment of osteoclast differentiation by high glucose	Biomedicines. 2021 Jun 7;9(6):648
Alternaria alternata	48, 96, 240, 480 μg ml–1	6 days	To test the inhibitory effect of Scopoletin on the growth of Alternaria alternata. Results showed that Scopoletin significantly inhibited fungal growth, with higher concentrations showing stronger inhibition.	J Exp Bot. 2014 Aug;65(15):4305-15
MC3T3-E1 cells	1–20 µM	7 days	Scopoletin enhanced ALP activity and mineralized bone nodule deposition, ameliorating the impairment of osteoblast differentiation by high glucose	Biomedicines. 2021 Jun 7;9(6):648
Jurkat T cells (C11 cell line)	0.25-2.0 mM	72 hours	Scopoletin reactivated latent HIV-1 transcription in a time-dependent manner, with GFP+ cells increasing from 8.02% to 42.65%	Int J Mol Sci. 2023 Aug 10;24(16):12649
Jurkat T cells (A10.6 cell line)	0.2-1.6 mM	72 hours	Scopoletin reactivated latent HIV-1 transcription in a dose-dependent manner, with GFP+ cells increasing from 10.72% to 28.87%	Int J Mol Sci. 2023 Aug 10;24(16):12649
CEM/ADR5000	37.5 µM (IC50)	72 hours	Evaluate the cytotoxicity of Scopoletin on CEM/ADR5000 cells	Molecules. 2016 Apr 15;21(4):496
CEM/ADR5000	37.5 ± 2.9 µM (IC50)	72 hours	Evaluate the cytotoxicity of Scopoletin on CEM/ADR5000 cells	Molecules. 2016 Apr 15;21(4):496
CCRF-CEM	26.1 ± 1.6 µM (IC50)	72 hours	Evaluate the cytotoxicity of Scopoletin on CCRF-CEM cells	Molecules. 2016 Apr 15;21(4):496

Tetranychus cinnabarinus (carmine spider mite)	Adult female mites	Dip method	0.938 mg/mL (LC50)	48 hours	To evaluate the acaricidal toxicity of scopoletin against T. cinnabarinus. Results showed that scopoletin exhibited significant acaricidal activity with an LC50 value of 0.938 mg/mL.	Front Physiol. 2019 Mar 6;10:164
Male mice	DSS-induced colitis model	Oral	1 mg/kg, 1.5 mg/kg, 2 mg/kg	Once daily, starting 14 days prior to and during DSS treatment	Scopoletin significantly improved DSS-induced colitis symptoms, including reduced weight loss and colonic shortening, decreased levels of TNF-α, IL-1β, and IL-12 cytokines, attenuated NLRP3 inflammasome activation, and modulated the immune response by elevating PPARγ expression and suppressing NF-κB pathway activation. Additionally, scopoletin altered gut microbiota composition by increasing beneficial Lactobacillus and Bifidobacteria and reducing E. coli, and enhanced tight junction proteins, indicating improved intestinal barrier integrity.	Inflammation. 2025 Apr;48(2):575-589
Sprague Dawley rats	High-fat, high-fructose diet (HFFD)-fed rats	Oral	1 mg/kg/day	Once daily for 45 days	To evaluate the effect of SPL on HFFD-induced pancreatic ER stress. SPL reduced the phosphorylation levels of IRE1α, PERK, and ATF6α induced by HFFD and inhibited the phosphorylation of JNK, indicating that SPL effectively alleviated pancreatic ER stress.	Cell Stress Chaperones. 2018 Sep;23(5):857-869
Db/db mice	Type 2 diabetes model	Oral	10 mg/kg	Once daily for 10 weeks	Scopoletin inhibited bone loss by enhancing the induction of bone turnover markers, increasing bone mineral density and content	Biomedicines. 2021 Jun 7;9(6):648
Wistar rats	MG-induced diabetic model	Oral administration	10 mg/kg	Once daily for 12 weeks	To investigate the protective effects of scopoletin against MG-induced hyperglycemia and insulin resistance, results showed that scopoletin improved OGTT results, reduced fasting blood glucose, restored C-peptide levels, ameliorated dyslipidemia, and promoted MG metabolism into D-lactic acid by activating Nrf2, thereby inhibiting AGEs generation.	Molecules. 2015 Feb 9;20(2):2786-801
Sprague-Dawley rats	Healthy rats	Oral	100 mg/kg	Single dose	Evaluate pharmacokinetics and biodistribution of Sco-Ms	Acta Pharmacol Sin. 2017 Mar;38(3):424-433
Zebrafish embryos	Zebrafish embryo developmental toxicity model	Aqueous solution exposure	18.5 µg/mL	Exposure solution changed daily until 120 hpf	Evaluated the metabolic effects of Scopoletin on zebrafish embryos, revealing significant metabolic disturbances	Metabolites. 2022 Oct 1;12(10):934
C57BL/6 mice	Complete Freund’s adjuvant (CFA)-induced chronic inflammation anxiety model	Intraperitoneal injection	2.0, 10.0, 50.0 mg/kg	Once daily for 14 consecutive days	SP dose-dependently ameliorated CFA-induced anxiety-like behaviors, inhibited microglia activation, decreased peripheral and central IL-1β, IL-6, and TNF-α levels, and modulated the imbalance of excitatory/inhibitory receptors and neurotransmitters	Mol Brain. 2020 Feb 4;13(1):15
Drosophila melanogaster	Park13 mutant flies	Oral administration	2.5 mM	Continuous treatment starting from 10 days AEL	To assess the neuroprotective effects of Sp in a Parkinson's disease model, results showed that Sp improved the survivability of dopaminergic neurons, reduced oxidative stress, and restored motor abilities.	Cell Death Dis. 2020 Sep 10;11(9):739
BALB/c nude mice	HepG2 xenograft model	Intraperitoneal injection	2.5, 5, 10 mg/kg	Once daily for 14 days	SC-III3 significantly inhibited tumor growth with inhibition rates of 31.2%, 38.6%, and 52.4%	BMC Cancer. 2014 Dec 19;14:987
Korean native chickens	High stocking density stress model	Dietary supplementation	20 mg/kg diet	Once daily for 35 days	To investigate the effects of Scopoletin on growth performance, antioxidant activity, and meat quality of chickens under high stocking density stress. Results showed that Scopoletin supplementation decreased MDA concentration in serum and leg muscle, increased catalase, superoxide dismutase, and total antioxidant capacity, and improved meat quality and growth performance.	Foods. 2021 Jun 29;10(7):1505
C57BL/6 mice	Experimental autoimmune encephalomyelitis (EAE) model	Intraperitoneal injection	50 mg/kg	Once daily for 20 days	Scopoletin significantly ameliorated the severity of EAE, reduced inflammation and demyelination in the CNS, and inhibited DC activation and Th1/Th17 cell polarization.	Front Pharmacol. 2019 Aug 2;10:863
Soybean (Glycine max)	Asian soybean rust model	Foliar spray	500 μM	Single treatment	Scopoletin protected soybean from SBR by directly inhibiting Pp development rather than activating the plant defense system.	Plant J. 2019 Aug;99(3):397-413
Soybean (Glycine max)	Soybean cyst nematode (Heterodera glycines) infection model	Seed coating	70:1 (w:v) seed coating	Field experiments in 2017 and 2018	Evaluate the biocontrol effect of Scopoletin against soybean cyst nematode. Scopoletin treatment significantly reduced nematode numbers in roots and soil, and promoted soybean growth and yield.	Life (Basel). 2021 Oct 26;11(11):1143
Rats	Healthy rats	Intravenous and oral	Intravenous 5 mg/kg; oral 5, 10, and 20 mg/kg	Single dose	To study the pharmacokinetics and oral bioavailability of Scopoletin in rats. The results showed that the oral bioavailability was 6.62% ± 1.72% for 5 mg/kg, 5.59% ± 1.16% for 10 mg/kg, and 5.65% ± 0.75% for 20 mg/kg.	Molecules. 2015 Oct 19;20(10):18988-9001

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CAS No.: 92-61-5

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CAS No.: 92-61-5

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Preparing Stock Solutions		1mg	5mg	10mg
Preparing Stock Solutions	1 mM 5 mM 10 mM	5.20mL 1.04mL 0.52mL	26.02mL 5.20mL 2.60mL	52.04mL 10.41mL 5.20mL
Dissolving Methods	Animal experiment Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn: in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day; The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound. Protocol 1 Protocol 2

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed