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Chemical Structure| 1933514-13-6 Chemical Structure| 1933514-13-6

Structure of Sebetralstat
CAS No.: 1933514-13-6

Chemical Structure| 1933514-13-6

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Sebetralstat is a plasma kallikrein inhibitor used in research for treating hereditary angioedema and other metabolic diseases.

Synonyms: KVD900

4.5 *For Research Use Only !

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Product Details of Sebetralstat

CAS No. :1933514-13-6
Formula : C26H26FN5O4
M.W : 491.51
SMILES Code : O=C(C1=CN(CC2=CC=C(CN3C=CC=CC3=O)C=C2)N=C1COC)NCC4=NC=CC(OC)=C4F
Synonyms :
KVD900
MDL No. :MFCD34567615

Safety of Sebetralstat

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Isoform Comparison

Biological Activity

In Vivo:

Species
Animal Model
Administration Dosage Frequency Description References
Sprague-Dawley rats Sprague-Dawley rats Intravenous and oral 1 mg/kg iv and 10 mg/kg po Single dose Evaluate pharmacokinetic parameters PMC9620001

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT06628713 Hereditary Angioedema AVAILABLE - KalVista Investigative Site, S... More >>cottsdale, Arizona, 85251, United States Less <<

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.03mL

0.41mL

0.20mL

10.17mL

2.03mL

1.02mL

20.35mL

4.07mL

2.03mL

 

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