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Structure of 1229022-83-6

Chemical Structure| 1229022-83-6

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Product Citations

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Yang, Ruili ; Xu, Jinchun ; Xu, Yi ; Huang, Chengqing ; Zhu, Feng ; Wang, Tian , et al.

Abstract: As a prevalent neurodevelopmental disease, whether ASD (autism spectrum disorder) can be ameliorated by the early use of a single microbe remains unknown. Here we report that Lacticaseibacillus rhamnosus GR-1 (LGR-1) prevented the occurrence of autism-like behaviors when administered exclusively to the pregnant mice, as evidenced by the improved behaviors and restored E/I balance in the prefrontal cortex of male pups. In parallel, the offspring microbiome was reshaped by LGR-1 treatment, mediated by the vertical transmission of maternal microbiome, with its roles validated by microbiota transplant and cross-fostering. In addition to gut commensals, the LGR-1-shaping vaginal microbiota also contributed to the establishment of “benecial” microbiome. Regarding key taxa in offspring, Akkermansia muciniphila was inuenced by LGR-1 and exerted effect on the ensuing behavior, through modulating immune pathways related to IL-17-producing cell population. In conclusion, a single microbe applied in utero protects offspring from autism-like behaviors via microbiome transmission, shedding light on the microbe-based avenue to mitigate the risk of ASD.

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Product Details of [ 1229022-83-6 ]

CAS No. :1229022-83-6
M.W : 146.24 kDa
SMILES Code : NONE
MDL No. :N/A

Safety of [ 1229022-83-6 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330
 

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