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CAS No. :	289656-45-7
Formula :	C₂₀H₁₅F₂NO
M.W :	323.34
SMILES Code :	O=C(N)C(C1=CC=C(F)C=C1)(C2=CC=C(F)C=C2)C3=CC=CC=C3
Synonyms :	ICA-17043
MDL No. :	MFCD09027349
InChI Key :	SCTZUZTYRMOMKT-UHFFFAOYSA-N
Pubchem ID :	216327

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H315-H319-H335
Precautionary Statements:	P261-P305+P351+P338

mouse microglial cells	7 nM	24 h	Senicapoc inhibited KCa3.1 currents, reduced ATP-induced Ca2+ signaling, and suppressed the expression of pro-inflammatory cytokines and enzymes.	PMC11106165
WM266-4 cells	30 µM	72 h	To evaluate the effect of Senicapoc on WM266-4 cell viability, results showed a significant decrease in cell viability	PMC10671816
Panc-1 cells	30 µM	72 h	To evaluate the effect of Senicapoc on Panc-1 cell viability, results showed a significant decrease in cell viability	PMC10671816
human CD3+ T cells	100 nM, 250 nM, 1 µM	48 h	To study the effect of Senicapoc on T cell proliferation and cytokine production, results showed that Senicapoc decreased the production of IL-2, IFN-γ, IL-12, and IL-17A, but not TNF-α and IL-10	PMC4216648
BDKO cells	0.5 µM	4 min	significantly blocked Tmem63b-mediated PLS	PMC11366033

C57BL/6J mice	transient middle cerebral artery occlusion model	intraperitoneal injection	10 mg/kg and 40 mg/kg	every 12 hours for a total of 14 doses	Senicapoc significantly reduced infarct area, improved neurological deficits, and decreased microglia/macrophage and T cell infiltration and activation.	PMC11106165
Mice	KCa3.1-overexpressing mice	Chow administration	30 mg/day	Once daily for 2 weeks	Senicapoc treatment prevented the intestinal phenotype in KCa3.1-overexpressing mice, including changes in water intake, frequency, and amplitude of duodenal contractions.	PMC6429421
mice	MPTP-induced Parkinson's disease model	oral	100 mg/kg	once daily for 5 days	To study the effect of Senicapoc on MPTP-induced Parkinson's disease model, results showed that Senicapoc improved locomotor ability, increased TH-positive neuron number, and attenuated microglial activation and neuroinflammation	PMC6931251

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CAS No.: 289656-45-7

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CAS No.: 289656-45-7

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NCT00102791	Sickle Cell Disease	PHASE3	TERMINATED	2025-06-07	Mobile, Alabama, United States... More >>\|Little Rock, Arkansas, United States\|Davis, California, United States\|Los Angeles, California, United States\|Oakland, California, United States\|Denver, Colorado, United States\|Hartford, Connecticut, United States\|Washington, District of Columbia, United States\|Holly Hill, Florida, United States\|Hollywood, Florida, United States\|Jacksonville, Florida, United States\|Augusta, Georgia, United States\|Savannah, Georgia, United States\|Chicago, Illinois, United States\|Iowa City, Iowa, United States\|New Orleans, Louisiana, United States\|Shreveport, Louisiana, United States\|Baltimore, Maryland, United States\|Boston, Massachusetts, United States\|Detroit, Michigan, United States\|Jackson, Mississippi, United States\|Kansas City, Missouri, United States\|Las Vegas, Nevada, United States\|Hackensack, New Jersey, United States\|New Brunswick, New Jersey, United States\|Newark, New Jersey, United States\|Bronx, New York, United States\|Brooklyn, New York, United States\|Chapel Hill, North Carolina, United States\|Durham, North Carolina, United States\|Greenville, North Carolina, United States\|Winston-Salem, North Carolina, United States\|Cincinnati, Ohio, United States\|Cleveland, Ohio, United States\|Philadelphia, Pennsylvania, United States\|Pittsburgh, Pennsylvania, United States\|Charleston, South Carolina, United States\|Memphis, Tennessee, United States\|Nashville, Tennessee, United States\|Houston, Texas, United States\|San Antonio, Texas, United States\|Richmond, Virginia, United States\|Porto Alegre, Brazil\|Rio de Janeiro, Brazil\|Sao Paulo, Brazil\|Creteil, France\|Kingston, Jamaica\|Port of Spain, Trinidad and Tobago\|London, United Kingdom Less <<
NCT00294541	Sickle Cell Disease\|Sickle Cel... More >>l Anemia Less <<	PHASE3	TERMINATED	2025-06-07	University of South Alabama, M... More >>obile, Alabama, 36617, United States\|Arkansas Children's Hospital, Little Rock, Arkansas, 72202, United States\|Children's Hospital Oakland, Oakland, California, 94609, United States\|University of California Davis Medical Center, Sacramento, California, 95817, United States\|University of Colorado Health Sciences Center, Denver, Colorado, 80262, United States\|Century Clinical Research, Inc., Holly Hill, Florida, 32117, United States\|University of Florida Health Science Center, Jacksonville, Florida, 32209, United States\|Medical College of Georgia, Augusta, Georgia, 30912, United States\|Memorial Health University Medical Center, Savannah, Georgia, 31404, United States\|University of Illinois Medical Center, Chicago, Illinois, 60612, United States\|Sickle Cell Center of Northern Louisiana, Shreveport, Louisiana, 71103, United States\|Johns Hopkins University School of Medicine, Baltimore, Maryland, 21205, United States\|Brigham and Women's Hospital, Boston, Massachusetts, 02115, United States\|Wayne State School of Medicine, Detroit, Michigan, 48201, United States\|University of Mississippi Medical Center, Jackson, Mississippi, 39216, United States\|Hackensack University Medical Center, Hackensack, New Jersey, 07601, United States\|Robert Wood Johnson Medical Center, New Brunswick, New Jersey, 08903, United States\|Newark Beth Israel Medical Center, Newark, New Jersey, 07112-2027, United States\|SUNY Downstate Medical Center, Brooklyn, New York, 11203, United States\|New York Methodist Hospital, Brooklyn, New York, 11215, United States\|University of North Carolina Hospitals, Chapel Hill, North Carolina, 27514, United States\|Duke University Medical Center, Durham, North Carolina, 27710, United States\|East Carolina University School of Medicine, Greenville, North Carolina, 27858, United States\|Wake Forest University School of Medicine, Winston-Salem, North Carolina, 27157, United States\|University of Cincinnati, Cincinnati, Ohio, 45219, United States\|Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, 19107, United States\|St. Christopher's Hospital for Children, Philadelphia, Pennsylvania, 19134-1095, United States\|Medical University of South Carolina, Charleston, South Carolina, 29425, United States\|Baylor College of Medicine, Houston, Texas, 77030, United States\|Medical College of Virginia, Richmond, Virginia, 23298-0157, United States\|Virginia Commonwealth University, Richmond, Virginia, 23298, United States Less <<
NCT00040677	Sickle Cell Disease ... More >> Sickle Cell Anemia Less <<	Phase 2	Completed	-	United States, Alabama ... More >> Study Site Birmingham, Alabama, United States United States, California Study Site Oakland, California, United States Study Site San Francisco, California, United States United States, District of Columbia Study Site Washington, District of Columbia, United States United States, Georgia Study Site Augusta, Georgia, United States United States, Illinois Study Site Chicago, Illinois, United States United States, Maryland Study Site Baltimore, Maryland, United States United States, Massachusetts Study Site Boston, Massachusetts, United States United States, Michigan Study Site Detroit, Michigan, United States United States, Mississippi Study Site Jackson, Mississippi, United States United States, New York Study Site Brooklyn, New York, United States Study Site New York, New York, United States United States, North Carolina Study Site Chapel Hill, North Carolina, United States Study Site Durham, North Carolina, United States United States, Pennsylvania Study Site Philadelphia, Pennsylvania, United States Study Site Pittsburgh, Pennsylvania, United States United States, Tennessee Study Site Nashville, Tennessee, United States United States, Texas Study Site Houston, Texas, United States United States, Virginia Study Site Richmond, Virginia, United States Less <<
NCT00861211	Atopic Asthma	Phase 2	Completed	-	United Kingdom ... More >> Guy's Drug Research Unit London, UK, United Kingdom, SE1 1YR Medicines Evaluation Unit Manchester, UK, United Kingdom, M23 9QZ Less <<
NCT00861185	Exercise Induced Asthma	Phase 2	Completed	-	United States, California ... More >> Huntington Beach, California, United States, 92647 Orange, California, United States, 92868 United States, Illinois Normal, Illinois, United States, 61761 United States, Louisiana Metairie, Louisiana, United States, 70006 United States, Missouri St. Louis, Missouri, United States, 63141 United States, New Jersey Skillman, New Jersey, United States, 08558 United States, New York North Syracuse, New York, United States, 13212 United States, Ohio Canton, Ohio, United States, 44718 United States, Washington Seattle,, Washington, United States, 98105 Less <<
NCT04594668	ARDS, Human\|COVID	PHASE2	UNKNOWN	2021-12-31	Aalborg University Hospital, A... More >>alborg, 9000, Denmark\|Aarhus University Hospital, Aarhus, 8000, Denmark\|Hvidovre Hospital, Hvidovre, 2650, Denmark\|Odense University Hospital, Odense, 5000, Denmark Less <<

Bio Calculators
Preparing Stock Solutions		1mg	5mg	10mg
Preparing Stock Solutions	1 mM 5 mM 10 mM	3.09mL 0.62mL 0.31mL	15.46mL 3.09mL 1.55mL	30.93mL 6.19mL 3.09mL
Dissolving Methods	Animal experiment Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn: in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day; The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound. Protocol 1 Protocol 2

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed