Type	HazMat fee for 500 gram (Estimated)
Excepted Quantity	USD 0.00
Limited Quantity	USD 15-60
Inaccessible (Haz class 6.1), Domestic	USD 80+
Inaccessible (Haz class 6.1), International	USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic	USD 100+
Accessible (Haz class 3, 4, 5 or 8), International	USD 200+

Size	Price	VIP Price	US Stock	Global Stock	In Stock
{[ item.pr_size ]}		Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

CAS No. :	256414-75-2
Formula :	C₂₀H₁₀F₆N₂OS
M.W :	440.36
SMILES Code :	FC(C1=CC(C2=NOC(C3=CC(C4=CC=CC=C4)=C(C(F)(F)F)S3)=N2)=CC=C1)(F)F
MDL No. :	MFCD00096600
InChI Key :	OYMNPJXKQVTQTR-UHFFFAOYSA-N
Pubchem ID :	4077460

GHS Pictogram:
Signal Word:	Danger
Hazard Statements:	H300
Precautionary Statements:	P264-P301+P310
Class:	6.1
UN#:	2811
Packing Group:	Ⅲ

Human mature oligodendrocytes	100 nM	2 days	Induced membrane elaboration	Am J Pathol. 2008 Oct;173(4):1143-52
Human ILC3	1 µM	2-3 days	Inhibited production of GM-CSF, IL-22, and IL-17	Front Immunol. 2019 Feb 13;10:217
Rat sensory neurons	100 nM	10 min	To evaluate the effect of SEW2871 on the excitability of rat sensory neurons, results showed that SEW2871 significantly increased the firing frequency of action potentials.	J Neuroinflammation. 2015 Apr 12;12:70
CeL-Sst neurons (Type B)	100 nM	10 minutes	SEW2871 significantly depolarized the resting membrane potential and increased input resistance of Type B neurons, but did not change firing frequency.	Neuropharmacology. 2022 Feb 1;203:108885
CeL-Sst neurons (Type A)	100 nM	10 minutes	SEW2871 did not significantly alter the resting membrane potential or firing frequency of Type A neurons.	Neuropharmacology. 2022 Feb 1;203:108885
Immortalized mouse podocytes	1 µM	14 days	SEW2871 significantly reduced TNF-α and VEGF mRNA expression in podocytes under high glucose conditions.	Kidney Int. 2011 May;79(10):1090-8
Mouse peritoneal macrophages	1 µM	30 minutes	SEW2871 stimulates the interaction between SR-B1 and S1PR1-eGFP, similar to HDL, and this interaction was blocked by an inhibitor of SR-B1’s lipid transport activity or an SR-B1 blocking antibody.	J Lipid Res. 2024 May;65(5):100541
HEK293A-S1P1-GFP cells	5 µM	30 minutes	To evaluate the effect of SEW2871 on S1PR1 internalization. Results showed SEW2871 significantly promoted S1PR1 internalization, which could be blocked by S1PR1 antagonist W146.	Cancer Lett. 2021 May 28;506:107-119
Human umbilical vein endothelial cells (HUVEC)	5 µM	30 minutes	To evaluate the inhibitory effect of SEW2871 on inflammatory mediator-induced endothelial gap formation. Results showed SEW2871 effectively inhibited BK, VEGF and IL-8 induced endothelial gap formation.	Cancer Lett. 2021 May 28;506:107-119
C57BL/6J peritoneal macrophages	1 µM	4 hours	SEW2871 significantly reduced LPS-mediated iNOS activity and TNF α secretion and increased Arg I activity, suggesting that the antiinflammatory effects of S1P in macrophages are mediated by the S1P1 receptor.	Circ Res. 2008 Apr 25;102(8):950-8

{[proInfo.proName]}

CAS No.: 256414-75-2

{[proInfo.proName]}

CAS No.: 256414-75-2

Alternative Products

Product Details of SEW2871

Safety of SEW2871

Related Pathways of SEW2871

Isoform Comparison

Biological Activity

Protocol

References

Historical Records

Categories

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

Molarity Calculator

Total Compounds Calculator

Dissolution Calculator

Rats	Streptozotocin-induced diabetic nephropathy model	Intraperitoneal injection	0.1 mg/kg	Monday to Friday, for 9 weeks	SEW2871 significantly reduced urinary albumin excretion and TNF-α levels in diabetic rats, and improved tubular injury and podocyte-specific protein expression.	Kidney Int. 2011 May;79(10):1090-8
Rats	Thermal hyperalgesia model	Intraplantar injection	0.3 μg	Single injection, sustained for 5 hours	SEW2871 induces thermal hyperalgesia via activation of S1P1 receptor, which can be blocked by the S1P1 receptor antagonist W146	Pain. 2011 Mar;152(3):643-648
Spontaneously hypertensive stroke-prone rats (SHRSP)	Unilateral carotid artery occlusion (UCAO) and Japanese permissive diet (JPD) model	Intraperitoneal injection	0.5 mg/kg	Every other day for 4 weeks	SEW2871 significantly reduced lesions in both white and grey matter and ameliorated cerebral blood flow. SEW2871 reversed the loss of endothelial S1PR 1 and tight junction proteins, and significantly attenuated UCAO/JPD induced accumulation of neuronal phosphorylated tau.	Aging Dis. 2024 May 21;16(2):1099-1119
Rats	Benign prostatic hyperplasia model	Intraprostatic injection	0.5 nmol	Single injection, duration of 4 weeks	SEW2871 led to prostate enlargement in rats	iScience. 2024 Oct 30;27(12):111290
Mice	ApoM-deficient mice	Intraperitoneal injection	10 mg/g	Single injection, 150 min prior to imaging	SEW2871 rapidly normalized paracellular BBB permeability in Apom-/- mice, and inhibited transcytosis in penetrating arterioles, but not in pial arterioles.	Elife. 2019 Nov 25;8:e49405
C57BL/6J mice	Epilepsy model	Intraperitoneal injection	10 mg/kg	Once a day for 48 hours	SEW2871 decreased the level of tight junction protein in the hippocampus of epileptic mice, increased blood-brain barrier leakage, and aggravated the severity of seizures compared with the control.	Neural Regen Res. 2023 Aug;18(8):1763-1769
Mice	Partial hepatectomy (PH) model and bile duct ligation (BDL) model	Oral gavage	10 mg/kg/day	Once daily for 7 days	SEW2871 promotes liver regeneration and alleviates fibrosis by activating endothelial S1P1 signaling. In Apom-/- mice, SEW2871 enhanced the restoration of liver weight, prolonged animal survival, and improved hepatic function recovery. Additionally, SEW2871 reduced fibrosis and thrombosis.	Cancer Med. 2020 Oct;9(19):7125-7136
Mice	Partial hepatectomy (PH) model and bile duct ligation (BDL) model	Oral gavage	10 mg/kg/day	Once daily for 7 days	SEW2871 promotes liver regeneration and alleviates fibrosis by activating endothelial S1P1 signaling. In Apom-/- mice, SEW2871 enhanced the restoration of liver weight, prolonged animal survival, and improved hepatic function recovery. Additionally, SEW2871 reduced fibrosis and thrombosis.	JCI Insight. 2016 Dec 22;1(21):e87058
C57BL/6J male mice	Chronic migraine model	Intraperitoneal injection	20 mg/kg	Once daily for 9 days	SEW2871 did not attenuate thermal and mechanical allodynia caused by repeated NTG administration	J Headache Pain. 2022 Feb 10;23(1):25
C57BL/6 mice	VEGFR blockade-induced emphysema model	Gavage	20 mg/kg	Once daily for 5 days	To evaluate the protective effect of SEW2871 on VEGFR blockade-induced airspace enlargement. Results showed that SEW2871 significantly inhibited airspace enlargement and reduced lung apoptosis.	Am J Respir Crit Care Med. 2010 Feb 15;181(4):344-52
Mice	Repeated hapten application-induced cutaneous response model	Gavage	20 mg/kg	Single administration	SEW2871 decreased the number of skin-infiltrating eosinophils and reduced the late-phase reaction.	Am J Pathol. 2010 Oct;177(4):1881-7
Mice	Transverse Aortic Constriction (TAC) model	Intraperitoneal injection	3 mg/kg	1 hour before surgery and every 12 hours thereafter for 72 hours	To evaluate the protective effects of SEW2871 on cardiac inflammation and function, results showed SEW2871 significantly reduced myocardial inflammation and preserved cardiac function.	JCI Insight. 2016 Apr 21;1(5):e85484
Mice	CX3CR1-EGFP knock-in mice and CSF1R-EGFP transgenic mice	Intravenous injection	5 mg/kg	Single dose	To evaluate the effect of SEW2871 on monocyte migration in bone tissues, showing that SEW2871 significantly increased the motility of CX3CR1-EGFP positive cells.	Nature. 2009 Mar 26;458(7237):524-8
Athymic Foxn1nu nude mice	Melanoma lung metastasis model	Intraperitoneal injection	5 mg/kg	Single dose, 6, 12 or 18 hours before	To evaluate the inhibitory effect of SEW2871 on melanoma lung metastasis. Results showed SEW2871 treatment reduced lung metastatic nodules by 65-80%.	Cancer Lett. 2021 May 28;506:107-119
Rats	Transient middle cerebral artery occlusion model	Intraperitoneal injection	5mg/kg	Single dose immediately after reperfusion	To evaluate the neuroprotective effect of SEW2871 on cerebral ischemia, results showed that SEW2871 significantly reduced infarct volume and improved neurological score	Stroke. 2010 Feb;41(2):368-74

Bio Calculators
Preparing Stock Solutions		1mg	5mg	10mg
Preparing Stock Solutions	1 mM 5 mM 10 mM	2.27mL 0.45mL 0.23mL	11.35mL 2.27mL 1.14mL	22.71mL 4.54mL 2.27mL
Dissolving Methods	Animal experiment Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn: in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day; The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound. Protocol 1 Protocol 2

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed