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CAS No. :	802918-57-6
Formula :	C₂₅H₂₂O₁₀
M.W :	482.44
SMILES Code :	O=C1[C@@H]([C@H](OC2=CC(O)=CC(O)=C12)C3=CC=C4OC(C(OC4=C3)C5=CC=C(C(OC)=C5)O)CO)O
Synonyms :	Silibinin
MDL No. :	MFCD00872186

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H315-H319-H335
Precautionary Statements:	P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P362-P403+P233-P501

HepG2 cells	2, 10, 50 µM	24 hours	To evaluate the effect of silybin on P450s activity under TG-induced ER stress. Results showed that silybin at medium and low concentrations ameliorated P450s activity, while high concentration may inhibit P450s activity.	Acta Pharmacol Sin. 2023 Jan;44(1):133-144.
LX-2 cells	20 μg/mL	24 hours	Evaluate the inhibitory effect of SLB nanosuspension on collagen I secretion, results showed NS-SLB and NS-SLB-HC significantly inhibited collagen I secretion	Int J Nanomedicine. 2023 Sep 12;18:5197-5211.
3T3-L1 adipocytes	30 µM or 80 µM	24 hours	To evaluate the effect of Silybin on TNFα secretion and glucose uptake. Silybin 80 µM as post-treatment or pre-treatment decreased TNFα levels, improving glucose uptake, but the glucose uptake enhancement did not depend on GLUT4 protein expression.	Adipocyte. 2024 Dec;13(1):2374062
SKOV3 cells	100 µM	24 hours	Silybin inhibits mitochondrial oxidative phosphorylation and the PPP pathway.	Cancer Sci. 2022 Sep;113(9):3032-3043.
OVCAR3 cells	50 µM and 100 µM	24 hours and 48 hours	Silybin inhibits cell proliferation and induces apoptosis by increasing ROS levels.	Cancer Sci. 2022 Sep;113(9):3032-3043.
SCC (Huh7:LX2 coculture)	5-7.5 µM	24, 96, 144 hours	To assess the effect of Silybin on cell viability and collagen deposition in the coculture model. Silybin showed no toxic effects and significantly reduced FFA-induced collagen deposition (40% reduction, 5 µM Silybin).	Molecules. 2019 Apr 2;24(7):1280
Huh7 cells	5-7.5 µM	24, 96, 144 hours	To assess the effect of Silybin on Huh7 cell viability and proliferation. Silybin significantly reduced cell viability at the highest concentration after 144 h (≈22%). FFA treatment did not significantly affect Huh7 cell viability, but the combination of FFA + Silybin showed deleterious effects at 96 and 144 h.	Molecules. 2019 Apr 2;24(7):1280
LX2 cells	5-7.5 µM	24, 96, 144 hours	To assess the effect of Silybin on LX2 cell viability and proliferation. Silybin significantly reduced cell viability at the highest concentration after 144 h (≈18%). FFA treatment increased LX2 cell proliferation, which was partially reversed by Silybin.	Molecules. 2019 Apr 2;24(7):1280
HeLa	10 µM and 50 µM	48 hours	Evaluation of antiproliferative activity, results showed inhibition of proliferation at 10 µM and 50 µM	Molecules. 2022 Mar 5;27(5):1702
WM266	10 µM and 50 µM	48 hours	Evaluation of antiproliferative activity, results showed inhibition of proliferation at 10 µM and 50 µM	Molecules. 2022 Mar 5;27(5):1702
A375	10 µM and 50 µM	48 hours	Evaluation of antiproliferative activity, results showed inhibition of proliferation at 10 µM and 50 µM	Molecules. 2022 Mar 5;27(5):1702
Jurkat	10 µM and 50 µM	48 hours	Evaluation of antiproliferative activity, results showed a reduction in proliferation of about 20% at 10 µM and more than 40% at 50 µM	Molecules. 2022 Mar 5;27(5):1702
RAW 264.7 cells	1.0 μg/mL to 50 μg/mL	48 hours	Evaluate the cytotoxicity of SLB nanosuspension, results showed SLB exhibited low toxicity against RAW 264.7 cells at concentrations up to 50 μg/mL	Int J Nanomedicine. 2023 Sep 12;18:5197-5211.
LO2 cells	1.0 μg/mL to 50 μg/mL	48 hours	Evaluate the cytotoxicity of SLB nanosuspension, results showed SLB exhibited low toxicity against LO2 cells at concentrations up to 50 μg/mL	Int J Nanomedicine. 2023 Sep 12;18:5197-5211.
HepG2 cells	1.0 μg/mL to 50 μg/mL	48 hours	Evaluate the cytotoxicity of SLB nanosuspension, results showed SLB exhibited low toxicity against HepG2 cells at concentrations up to 50 μg/mL	Int J Nanomedicine. 2023 Sep 12;18:5197-5211.
HepG2 cells	68 µM	48 hours	To evaluate the effect of Silybin on BPA-induced lipid peroxidation. Results showed that Silybin significantly reduced BPA-induced lipid peroxidation.	Sci Rep. 2019 Mar 1;9(1):3228
HepG2 cells	68 µM	48 hours	To evaluate the effect of Silybin on BPA-induced proliferation in HepG2 cells. Results showed that Silybin significantly counteracted BPA-induced cell proliferation.	Sci Rep. 2019 Mar 1;9(1):3228
HepG2 cells	68 µM	72 hours	Silybin induced growth inhibition by increasing nitric oxide (NO) production and MnSOD activity, reducing lipid peroxidation, blocking HepG2 cells in the G1 phase of the cell cycle and activating apoptosis. Additionally, silybin increased ceramide synthesis and modulated miRNA secretion, specifically upregulating miR223-3p and miR16-5p, and downregulating miR-92-3p.	Int J Mol Sci. 2019 May 3;20(9):2190.

BALB/c nude mice	Ovarian cancer xenograft model	Oral gavage	100 mg/kg	Once daily for 6 weeks	Silybin suppresses tumor growth of ovarian cancer cells via oral administration.	Cancer Sci. 2022 Sep;113(9):3032-3043.
Male C57BL/6J mice	MPTP-induced Parkinson's disease model	Oral	100, 200, 300, 400, 500 mg/kg	Once daily for 5 consecutive days	To evaluate the neuroprotective effects of silybin in the MPTP-induced Parkinson's disease model. Results showed that oral administration of silybin at 100 mg/kg preserved about 60% of dopamine levels, improved motor deficits, preserved neurotrophic factors content and mitochondrial function, reduced lipid peroxidation, diminished proinflammatory cytokines to basal levels, enhanced fractalkine production in the striatum and substantia nigra, and increased IL-10 and IL-4 levels in the substantia nigra in MPTP mice.	Mol Neurobiol. 2023 Dec;60(12):6774-6788
C57BL/6 mice	High-fat-diet induced nonalcoholic fatty liver disease model	Intragastric administration	50, 100 mg/kg/day	Once daily for 4 weeks	To investigate the effect of silybin on P450s activity in HFD-induced NAFLD mice. Results showed that silybin dose-dependently reversed the inhibition of P450s activity by HFD.	Acta Pharmacol Sin. 2023 Jan;44(1):133-144.
Kunming mice	CCl4-induced hepatic fibrosis model and bile duct ligation (BDL)-induced hepatic fibrosis model	Tail vein injection	8 mg/kg SLB	Twice a week, treatment lasted for 2 to 3 weeks	Evaluate the therapeutic effect of SLB nanosuspension on hepatic fibrosis, results showed NS-SLB and NS-SLB-HC significantly alleviated hepatic fibrosis, reduced ALT and AST levels, and inhibited the expression of α-SMA and collagen I	Int J Nanomedicine. 2023 Sep 12;18:5197-5211.

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CAS No.: 802918-57-6

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CAS No.: 802918-57-6

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Product Details of Silybin

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Precautionary Statements-General

Prevention

Response

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NCT03538327	Hypertension	PHASE4	COMPLETED	2025-05-14	-
NCT00915681	Amatoxin Poisoning\|Amanita Poi... More >>soning\|Mushroom Poisoning\|Liver Failure Less <<	PHASE2	TERMINATED	2020-04-10	Recruitment Hot Line for the U... More >>nited States, Somerset, New Jersey, 08873, United States\|Mylan Specialty LLP, Morgantown, West Virginia, 26504-4310, United States Less <<
NCT01129570	Advanced Hepatocellular Carcin... More >>oma Less <<	PHASE1	COMPLETED	2025-06-13	Columbia University Medical Ce... More >>nter, New York, New York, 10032, United States Less <<

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed