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Chemical Structure| 1214468-35-5 Chemical Structure| 1214468-35-5

Structure of SIRT2/6-IN-1
CAS No.: 1214468-35-5

Chemical Structure| 1214468-35-5

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SIRT2/6-IN-1 is a dual inhibitor of SIRT6 and SIRT2 with IC50 values of 106 μM and 114 μM, respectively. This compound increases H3K9 acetylation levels, enhances glucose uptake, and reduces TNF-α secretion, making it suitable for research on metabolic regulation and anti-inflammatory studies.

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Product Details of SIRT2/6-IN-1

CAS No. :1214468-35-5
Formula : C19H14N4O5S
M.W : 410.40
SMILES Code : O=S(C1=CC2=C(NC(NC2=O)=O)C=C1)(NC3=CC=C(OC4=CC=CN=C4)C=C3)=O
MDL No. :MFCD11667663
InChI Key :CNILPKOOBRBNEQ-UHFFFAOYSA-N
Pubchem ID :46966788

Safety of SIRT2/6-IN-1

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

Related Pathways of SIRT2/6-IN-1

epigenetics

Isoform Comparison

Biological Activity

Description
SIRT2/6-IN-1 inhibits SIRT6 and SIRT2, with IC50 values of 106 μM and 114 μM, respectively. It enhances H3K9 acetylation, boosts glucose uptake, and decreases TNF-α secretion in cells[1].

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.44mL

0.49mL

0.24mL

12.18mL

2.44mL

1.22mL

24.37mL

4.87mL

2.44mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

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