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Chemical Structure| 2374313-54-7 Chemical Structure| 2374313-54-7

Structure of SIS17
CAS No.: 2374313-54-7

Chemical Structure| 2374313-54-7

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SIS17 is a specific HDAC11 inhibitor with IC50 value of 0.83μM for inhibition of the demyristoylation HDAC11 substrate, serine hydroxymethyl transferase 2.

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Product Details of SIS17

CAS No. :2374313-54-7
Formula : C21H38N2OS
M.W : 366.60
SMILES Code : C(C1SC=CC=1)(=O)NNCCCCCCCCCCCCCCCC
MDL No. :N/A
InChI Key :HSHXDCVZWHOWCS-UHFFFAOYSA-N
Pubchem ID :139035087

Safety of SIS17

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P280-P301+P312-P302+P352-P305+P351+P338

Related Pathways of SIS17

epigenetics

Isoform Comparison

Biological Activity

In Vitro:

Cell Line
Concentration Treated Time Description References
MCF7 cells 12.5, 25.0, 50.0 μM 6 hours SIS17 significantly increased the fatty acylation level of SHMT2 in MCF7 cells down to 12.5 μM, demonstrating its cell permeability and ability to inhibit HDAC11 in living cells. PMC6893910

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.73mL

0.55mL

0.27mL

13.64mL

2.73mL

1.36mL

27.28mL

5.46mL

2.73mL

References

 

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