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Chemical Structure| 2254609-23-7 Chemical Structure| 2254609-23-7

Structure of SJFδ
CAS No.: 2254609-23-7

Chemical Structure| 2254609-23-7

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SJFδ is a PROTAC selectively targeting on p38δ, consist of a warhead of foretinib linked to VHL-recruiting ligand. SJFδ exhibited DC50/Dmax values of 79.2nM/98.4% and 45.9nM/34.5% for degradation of p38δ and p38α, respectively.

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Product Details of SJFδ

CAS No. :2254609-23-7
Formula : C62H63F2N7O12S
M.W : 1168.27
SMILES Code : O=C1N([C@@H](C(C)C)C(N2C[C@H](O)C[C@H]2C(NCC3=C(OCCOCCOCCOC4=C(OC)C=C(C(OC5=C(F)C=C(NC(C6(C(NC7=CC=C(F)C=C7)=O)CC6)=O)C=C5)=CC=N8)C8=C4)C=C(C9=C(C)N=CS9)C=C3)=O)=O)CC%10=C1C=CC=C%10
MDL No. :N/A

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Related Pathways of SJFδ

MAPK
TLR

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