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Chemical Structure| 1370256-78-2 Chemical Structure| 1370256-78-2

Structure of SKLB4771
CAS No.: 1370256-78-2

Chemical Structure| 1370256-78-2

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FLT3-IN-1 is a potent and selective Flt3 inhibitor with IC50 of 10 nM and against FLT3-ITD-expressing MV4-11 cells with IC50 of 6 nM.

Synonyms: FLT3-IN-1

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Product Details of SKLB4771

CAS No. :1370256-78-2
Formula : C25H27N7O3S2
M.W : 537.66
SMILES Code : O=C(NC1=CC=C(C)C=C1)NC2=NN=C(SC3=C4C=CC(OCCCN5CCOCC5)=CC4=NC=N3)S2
Synonyms :
FLT3-IN-1
MDL No. :MFCD28900746
InChI Key :LKXFSTAQMOENSC-UHFFFAOYSA-N
Pubchem ID :57412684

Safety of SKLB4771

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H320-H335
Precautionary Statements:P261-P280-P301+P312-P302+P352-P305+P351+P338

Related Pathways of SKLB4771

DNA
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Isoform Comparison

Biological Activity

Description
SKLB4771 is a highly potent and selective inhibitor of Flt3, exhibiting an IC50 value of 10 nM. It suppresses the phosphorylation of FLT3/STAT5/ERK, hinders cell proliferation, and triggers apoptosis in tumor tissue [1][2].

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.86mL

0.37mL

0.19mL

9.30mL

1.86mL

0.93mL

18.60mL

3.72mL

1.86mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

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