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Chemical Structure| 55084-08-7 Chemical Structure| 55084-08-7

Structure of Skullcapflavone II
CAS No.: 55084-08-7

Chemical Structure| 55084-08-7

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Skullcapflavone II is a flavonoid compound extracted from Scutellaria baicalensis, with anti-inflammatory and antimicrobial properties. It shows strong antibacterial activity against Mycobacterium aurum and Mycobacterium bovis BCG and can modulate the function of osteoclasts.

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Product Details of Skullcapflavone II

CAS No. :55084-08-7
Formula : C19H18O8
M.W : 374.34
SMILES Code : O=C1C=C(C2=C(OC)C=CC=C2O)OC3=C(OC)C(OC)=C(OC)C(O)=C13

Safety of Skullcapflavone II

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Isoform Comparison

Biological Activity

In Vitro:

Cell Line
Concentration Treated Time Description References
Human renal proximal tubular epithelial cell line (HK-2) 10 or 20 µM 24 hours SFII significantly alleviated AAI-induced DNA damage and apoptosis Acta Pharmacol Sin. 2023 Jul;44(7):1429-1441.
Human normal liver cell line (L02) 5 or 10 µM 24 or 48 hours SFII significantly alleviated AAI-induced DNA damage and apoptosis Acta Pharmacol Sin. 2023 Jul;44(7):1429-1441.

In Vivo:

Species
Animal Model
Administration Dosage Frequency Description References
C57BL/6 mice AAI-induced acute renal injury and fibrosis model Oral 30 or 60 mg/kg Pretreated with SFII 12 h before AAI and SFII co-administration for 3 consecutive days SFII dose-dependently ameliorated AAI-induced renal fibrosis and dysfunction Acta Pharmacol Sin. 2023 Jul;44(7):1429-1441.

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.67mL

0.53mL

0.27mL

13.36mL

2.67mL

1.34mL

26.71mL

5.34mL

2.67mL

 

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