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Chemical Structure| 1177600-74-6 Chemical Structure| 1177600-74-6

Structure of SMANT HCl
CAS No.: 1177600-74-6

Chemical Structure| 1177600-74-6

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SMANT hydrochloride is an effective Smoothened (Smo) signaling pathway inhibitor that exhibits equal inhibition of the oncogenic mutant SmoM2 and wild-type Smo. By inhibiting Smo accumulation in primary cilia (IC50 = 1.1 μM), this compound can be used to study diseases related to the Hedgehog pathway and the therapeutic potential in cancer.

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Product Details of SMANT HCl

CAS No. :1177600-74-6
Formula : C16H24BrClN2O
M.W : 375.73
SMILES Code : O=C(NC1=CC=C(Br)C=C1)CCN2CC(C)CC(C)C2.[H]Cl
InChI Key :XQESCHFXROUCOQ-UHFFFAOYSA-N
Pubchem ID :2900213

Safety of SMANT HCl

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H302-H361-H372-H410
Precautionary Statements:P201-P264-P280-P301+P330+P331-P312
Class:9
UN#:3077
Packing Group:

Related Pathways of SMANT HCl

Hedgehog

Isoform Comparison

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.66mL

0.53mL

0.27mL

13.31mL

2.66mL

1.33mL

26.61mL

5.32mL

2.66mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

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