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CAS No. :	67776-06-1
Formula :	C₇H₁₂N₂O₄S
M.W :	220.25
SMILES Code :	CC(C)(SN=O)C(C(O)=O)NC(C)=O
Synonyms :	S-Nitroso-N-acetyl-DL-penicillamine
MDL No. :	MFCD00272624
InChI Key :	ZIIQCSMRQKCOCT-UHFFFAOYSA-N
Pubchem ID :	5231

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H315-H319-H335
Precautionary Statements:	P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P321-P332+P313-P337+P313-P362-P403+P233-P405-P501

Human platelets	0.01-10 µM	10 min	Increase in intraplatelet cGMP concentrations	Br J Pharmacol. 1994 Aug;112(4):1071-6
Human platelets	3-10 µM	5 min	Inhibition of P-selectin release	Br J Pharmacol. 1994 Aug;112(4):1071-6
Human platelets	0.01-10 µM	1 min	Inhibition of collagen-induced platelet aggregation and ATP release	Br J Pharmacol. 1994 Aug;112(4):1071-6
Human platelets	3 or 10 µM	1-2 min	To study the inhibitory effect of SNAP on collagen-induced platelet aggregation, and found that ONOO- reversed the inhibitory effect of SNAP	Proc Natl Acad Sci U S A. 1994 Jul 5;91(14):6702-6
Dorsal root ganglia neurons	0.1-1 mM	1200 seconds	SNAP induced concentration-dependent increase in fluorescence intensity of DAF-treated neurons, and L-cysteine did not affect SNAP-induced fluorescence increase.	Neuropharmacology. 2013 Aug;71:1-9
Guinea-pig trachea strips with NK2 receptor antagonist SR 48968	100 µM	20 minutes	Examined SNAP's effect on acetylcholine release after NK2 receptor blockade. SNAP significantly inhibited release (78±3% of control).	Br J Pharmacol. 2000 Sep;131(1):94-8
Capsaicin-pretreated guinea-pig trachea strips	100 and 300 µM	20 minutes	Studied SNAP's effect on acetylcholine release after capsaicin pretreatment. SNAP's facilitatory effect was reversed to inhibition (74±4% and 78±2% of control), which was prevented by ODQ.	Br J Pharmacol. 2000 Sep;131(1):94-8
Epithelium-free preparation of guinea-pig trachea	100 and 300 µM	20 minutes	Investigated the effect of SNAP on electrically evoked [3H]-acetylcholine release. SNAP significantly increased release (121±4% and 124±10% of control), an effect abolished by the soluble guanylyl cyclase inhibitor ODQ (1 μM).	Br J Pharmacol. 2000 Sep;131(1):94-8
Rat colonic mucosal cells	0.1 – 1000 µM	20 minutes	To assess the extent of damage to colonic mucosal cells by SNAP, results showed increased cell damage as evaluated by Trypan blue dye uptake and lysosomal enzyme release.	Br J Pharmacol. 1999 Nov;128(6):1268-74
Arabidopsis nuclear extracts	10-1000 µM	20 minutes	To evaluate the effect of SNAP on HDAC activity; SNAP significantly inhibited nuclear HDAC activity (60% inhibition at 500 μM), reversible by DTT	Plant Physiol. 2017 Feb;173(2):1434-1452
BALB/cJ mouse peritoneal macrophages	500 µM	24 hours	SNAP inhibited the growth of MHV-3 in peritoneal macrophages from BALB/cJ mice.	J Virol. 1998 Sep;72(9):7084-90
A/J mouse peritoneal macrophages	500 µM	24 hours	SNAP inhibited the growth of MHV-3 in peritoneal macrophages from A/J mice.	J Virol. 1998 Sep;72(9):7084-90
RAW 264.7 cells	500 µM	24 hours	SNAP inhibited the growth of MHV-3 in RAW 264.7 cells, while NAP (an inactive analog of SNAP) had no effect.	J Virol. 1998 Sep;72(9):7084-90
NAc neurons	100 µM	30 minutes	Increased surface GluR2 expression by enhancing NSF S-nitrosylation and GluR2-NSF interactions	J Neurosci. 2014 Mar 5;34(10):3493-508
Human platelets	0.01-10 µM	5 min	Induction of disaggregation of ADP-aggregated platelets	Br J Pharmacol. 1994 Aug;112(4):1071-6
HEK293 cells	100 µM	5 minutes	To investigate the inhibitory effect of SNAP on N-type Ca2+ channel currents. Results showed that SNAP significantly inhibited N-type Ca2+ channel currents, and this effect was reversed by DTT.	J Biol Chem. 2015 Dec 18;290(51):30616-23
SHR rat coronary endothelial cells	100 µM	5 minutes	SNAP failed to modulate the α-thrombin-induced calcium transient.	Br J Pharmacol. 2000 Aug;130(7):1468-76
WKY rat coronary endothelial cells	10–100 µM	5 minutes	SNAP dose-dependently reduced the peak and decay time of α-thrombin-induced calcium transient. In one-third of the cells analyzed, 100 μM SNAP completely abolished the α-thrombin-induced calcium transient.	Br J Pharmacol. 2000 Aug;130(7):1468-76
SHR rat cardiomyocytes	1-200 µM	5 minutes	SNAP failed to further increase cGMP content	Br J Pharmacol. 2001 Oct;134(3):596-602
WKY rat cardiomyocytes	1-200 µM	5 minutes	SNAP dose-dependently increased cGMP content	Br J Pharmacol. 2001 Oct;134(3):596-602
Rat liver sinusoidal endothelial cells	2 mM	6 hours	To evaluate the cytotoxicity of low-concentration SNAP, results showed 15% cell death under hypoxic conditions.	Biochem J. 1996 Sep 15;318 ( Pt 3)(Pt 3):789-95
Rat liver sinusoidal endothelial cells	10 mM	6 hours	To assess the cytotoxicity of high-concentration SNAP, results showed 80% cell death under normoxic conditions.	Biochem J. 1996 Sep 15;318 ( Pt 3)(Pt 3):789-95
Human platelets	1 µM	60 min	Evaluation of stability of SNAP and SNFP, SNPL inhibitory activity decayed over time	Br J Pharmacol. 1994 Aug;112(4):1071-6
Arabidopsis protoplasts	500 µM	60 minutes	To assess SNAP's effect on HDAC activity in protoplasts; concentration-dependent inhibition (20% at 500 μM), blocked by cPTIO	Plant Physiol. 2017 Feb;173(2):1434-1452
Leishmania donovani amastigotes	10 to 160 μg/ml	72 hours	To assess the resistance of PMM-resistant strains to NO, showing enhanced resistance to NO at the intracellular amastigote stage.	Antimicrob Agents Chemother. 2019 Dec 20;64(1):e00904-19
Rat liver sinusoidal endothelial cells	5 mM	8 hours	To evaluate the cytotoxicity of SNAP under hypoxic conditions, results showed a significant increase in cell death to 90% under hypoxia compared to 45% under normoxia.	Biochem J. 1996 Sep 15;318 ( Pt 3)(Pt 3):789-95

Zucker rats	Obese Zucker rats (OZR) and lean Zucker rats (LZR)	In vitro (microvascular myographs)	0.3 nM	30 minutes	To assess the effect of ET-1 on endothelium-dependent and -independent relaxant responses in penile arteries, it was found that ET-1 inhibits NO-mediated endothelial relaxations via NADPH oxidase-dependent ROS generation and enhances vasoconstriction in obese animals.	Br J Pharmacol. 2014 Dec;171(24):5682-95
Sprague-Dawley rats	Cocaine behavioral sensitization model	Bilateral NAc injection	0.5 or 1 μg/side	Single injection, tested after 30 min	Dose-dependently attenuated the expression of cocaine-induced behavioral sensitization	J Neurosci. 2014 Mar 5;34(10):3493-508
BALB/c mice	CT26 colorectal cancer and 4T1 triple-negative breast cancer models	Intratumoral injection	1 μmol Hf (0.24 μmol SNAP)	4T1 model: 4 fractions of 2 Gy; CT26 model: 3 fractions of 3 Gy	SNAP/MOL(+) plus low-dose X-ray significantly inhibited tumor growth (TGI 81.2% in 4T1 model, 95.4% in CT26 model) and reduced lung metastasis	Adv Sci (Weinh). 2025 Feb;12(8):e2413518
Rats	Migraine model	Topical application	10 μM	30 minutes	To study the effect of SNAP on the mechanical sensitivity of meningeal nociceptors, results showed that SNAP promoted a delayed increase in mechanical sensitivity of nociceptors	Ann Neurol. 2013 Jun;73(6):741-50
Rats	Carrageenin-induced mechanical hyperalgesia	Local administration	200 µg/paw	Single dose, 30 minutes	SNAP inhibited carrageenin-induced mechanical hyperalgesia, and L-cysteine did not affect SNAP-induced anti-hyperalgesia.	Neuropharmacology. 2013 Aug;71:1-9
Rat	Isolated perfused heart model	Aortic cannula perfusion	5-10 nM	Single administration, lasting 30 sec	To investigate the protective effect of S-nitroso-N-acetyl-DL-penicillamine against peroxynitrite-induced vascular dysfunction. Results showed that SNAP at low concentrations did not induce vasodilatation but prevented the inhibition of vasodilator responses by peroxynitrite.	Proc Natl Acad Sci U S A. 1994 Dec 20;91(26):12383-7

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CAS No.: 67776-06-1

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CAS No.: 67776-06-1

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Product Details of SNAP

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Historical Records

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Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

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Preparing Stock Solutions		1mg	5mg	10mg
Preparing Stock Solutions	1 mM 5 mM 10 mM	4.54mL 0.91mL 0.45mL	22.70mL 4.54mL 2.27mL	45.40mL 9.08mL 4.54mL
Dissolving Methods	Animal experiment Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn: in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day; The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound. Protocol 1 Protocol 2

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed