SNS-032 (BMS-387032) | CDK Inhibitor

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CAS No. :	345627-80-7
Formula :	C₁₇H₂₄N₄O₂S₂
M.W :	380.53
SMILES Code :	O=C(C1CCNCC1)NC2=NC=C(SCC3=NC=C(C(C)(C)C)O3)S2
Synonyms :	BMS-387032
MDL No. :	MFCD09833875
InChI Key :	OUSFTKFNBAZUKL-UHFFFAOYSA-N
Pubchem ID :	3025986

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H315-H319-H335
Precautionary Statements:	P261-P305+P351+P338

Acute Myeloid Leukemia cells	50 nM	6 days	To evaluate the effect of SNS-032 on the proliferation of Acute Myeloid Leukemia cells, results showed that the combination of SNS-032 with abemaciclib significantly decreased the proliferation of REL_FREE cells.	PMC7140113
BRAFwt/NRASwt melanoma cells	10 μM		SNS-032 showed the greatest selectivity for BRAFwt/NRASwt lines	PMC8316294
22Rv1 cells	0.5 µM	24 hours	SNS-032 significantly downregulated the expressions of USP1 and SIX1	PMC8990483
PC3 cells	0.5 µM	24 hours	SNS-032 significantly downregulated the expressions of USP1 and SIX1	PMC8990483
PancVH1	0.5nM to 10μM	72 hours	To evaluate the anti-tumor activity of SNS-032 in PancVH1 cells, results showed significant cytotoxicity of SNS-032 in KRAS mutant PancVH1 cells.	PMC9481717
HPNE	0.5nM to 10μM	72 hours	To evaluate the cytotoxicity of SNS-032 in HPNE cells, results showed lower toxicity of SNS-032 in normal pancreatic cells.	PMC9481717
KYSE30	0.27 μM	72 hours	SNS-032 significantly inhibited cell viability with an IC50 value of 0.27 μM	PMC8571299
KYSE150	0.25 μM	72 hours	SNS-032 significantly inhibited cell viability with an IC50 value of 0.25 μM	PMC8571299
KYSE450	0.34 μM	72 hours	SNS-032 significantly inhibited cell viability with an IC50 value of 0.34 μM	PMC8571299
KYSE510	0.32 μM	72 hours	SNS-032 significantly inhibited cell viability with an IC50 value of 0.32 μM	PMC8571299
TE-1	0.28 μM	72 hours	SNS-032 significantly inhibited cell viability with an IC50 value of 0.28 μM	PMC8571299
MDA-MB-231	0.1 μM	72 hours	To evaluate the effect of SNS-032 on cell growth, results showed that SNS-032 significantly inhibited the growth of MDA-MB-231 cells.	PMC9322647
MDA-MB-468	0.2 μM	72 hours	To evaluate the effect of SNS-032 on cell growth, results showed that SNS-032 significantly inhibited the growth of MDA-MB-468 cells.	PMC9322647
HepG2	1 μM	6 h	SNS-032 accelerated the degradation of SIX1	PMC10043269
HepG2	1 μM	18 h	SNS-032 accelerated the degradation of RPS16	PMC10043269
HCT116	100 nM	24 hours	Induced DR5 expression	PMC10364554
HCT116	100 nM	8 hours	Inhibited p73 Thr86 phosphorylation	PMC10364554
MDA-MB-468	10 nmol/L	24 hours	To evaluate the internalization and antitumor functions of the ADC in high EGFR-expressing cells. Results showed that the ADC exhibited rapid internalization in MDA-MB-468 cells and accumulated in acidic lysosomal clusters, indicating effective release within tumor cells.	PMC9322647
CAL51	10 nmol/L	24 hours	To evaluate the internalization and antitumor functions of the ADC in low EGFR-expressing cells. Results showed minimal internalization of the ADC in CAL51 cells, indicating weaker inhibitory effects on low EGFR-expressing cells.	PMC11292198

nude mice	22Rv1 xenograft model	intraperitoneal injection	30 mg/kg	Twice weekly for 3 weeks	SNS-032 significantly inhibited tumor growth and induced tumor cell apoptosis	PMC8990483
nude mice	KYSE30 xenograft model	intraperitoneal injection	25 mg/kg	Twice a week for 2 weeks	SNS-032 significantly inhibited the growth of KYSE30 xenograft tumors, reducing tumor volume and weight	PMC8571299
mice	human MDA-MB-231 TNBC xenograft model	intravenous injection	20 mg/kg	every 2 days for 30 days	To evaluate the effect of SNS-032 on tumor growth, results showed that SNS-032 significantly restricted tumor growth and enhanced human immune cell infiltration.	PMC9322647
BALB/c nude mice	Hep3B xenograft model	intraperitoneal injection	15 mg/kg/day	3 days on/2 days off for 14 days	SNS-032 significantly inhibited the growth of Hep3B xenografts	PMC10043269
Nude mice	HCT116 xenograft model	Intraperitoneal injection	15 mg/kg	once weekly for 34 days	Inhibited tumor growth and induced DR5 expression and apoptosis	PMC10364554
NSG mice	Breast cancer xenograft model	Intravenous injection	15 mg·kg−1·d−1	every other day for 21 days	To evaluate the antitumor effects of the ADC in breast cancer xenograft models. Results showed that the ADC significantly inhibited the growth of MDA-MB-468 tumors without causing significant weight loss or toxicity.	PMC11292198

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CAS No.: 345627-80-7

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CAS No.: 345627-80-7

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NCT00292864	Tumors	Phase 1	Completed	-	United States, Arizona ... More >> Premiere Oncology of Arizona Scottsdale, Arizona, United States, 85260 United States, California University of California Davis Medical Center Davis, California, United States, 95817 United States, Massachusetts Dana-Farber Cancer Institute Boston, Massachusetts, United States, 02115 Beth Israel Deaconess Medical Center Boston, Massachusetts, United States, 02215 Massachusetts General Hospital Boston, Massachusetts, United States, 02215 United States, Pennsylvania Fox Chase Cancer Center Philadelphia, Pennsylvania, United States, 19111 Less <<
NCT00446342	B-lymphoid Malignancies ... More >> Chronic Lymphocytic Leukemia Mantle Cell Lymphoma Multiple Myeloma Less <<	Phase 1	Completed	-	United States, California ... More >> City of Hope Duarte, California, United States, 91010 Stanford Cancer Center Stanford, California, United States, 94305 United States, Georgia Winship Cancer Institute at Emory University Atlanta, Georgia, United States, 30322 United States, Maryland Greenebaum Cancer Center, University of Maryland Baltimore, Maryland, United States, 21201 United States, New Jersey Hackensack University Medical Center at the Cancer Center Hackensack, New Jersey, United States, 07601 United States, Texas MD Anderson Cancer Center, University of Texas Houston, Texas, United States, 77230 Less <<

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed