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Chemical Structure| 156-54-7 Chemical Structure| 156-54-7
Chemical Structure| 156-54-7

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Sodium Butyrate is a HDAC inhibitor that induces cell differentiation and inhibits cell proliferation. Sodium Butyrate can be used in research on cancer, inflammatory diseases, and metabolic disorders.

Synonyms: Butyric Acid; NaB; Butanoic acid sodium salt

4.5 *For Research Use Only !

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Product Citations

Product Citations

Binienda, Agata ; Machelak, Weronika ; Zielińska, Marta ; Fichna, Jakub ;

Abstract: High incidence of colorectal cancer (CRC) is influenced by diet low in fiber (source of short chain fatty acids, SCFAs, natural agonists for free fatty acid receptor type 2 (FFAR2)) and high in fat (main source of long chain fatty acids, LCFAs, FFAR4 agonists). FFAR2 and FFAR4 are downregulated in CRC. In this study, we characterized whether the anticancer effects of SCFAs and LCFAs are FFAR-dependent in in vitro and in vivo models of CRC. In vitro, SW-480 cell growth was determined after incubation with FFARs ligands (SCFAs: acetate, butyrate; LCFAs: palmitate, stearate) using MTT assay. Cell migration and invasion were investigated by wound healing and transwell-based invasion assays. In vivo, SCFAs and LCFAs were administered to azoxymethane/dextran sodium sulfate-treated mice. Real-time qPCR and Western blot were used to determine FFARs expression. SCFAs and LCFAs significantly decreased SW-480 cell growth, migration and invasion capacities. Combination of SCFAs and LCFAs induced synergistic inhibitory effects on CRC cell growth and motility. FFAR2 and FFAR4 expression were elevated in CRC cells treated with butyrate as well as with butyrate+acetate, and butyrate+palmitate+stearate. Concurrently, only FFAR4 expression was increased in CRC cells incubated with LCFAs. In vivo, treatment with LCFAs, but not SCFAs increased ffar2 and Ffar4 expression. Our findings showed that SCFAs and LCFAs inhibit cancer cell growth and their migration and invasion capabilities. Our study evidenced that the anticancer effects of SCFAs- and LCFAs are mediated by FFAR2 and FFAR4.

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Product Details of Sodium Butyrate

CAS No. :156-54-7
Formula : C4H7NaO2
M.W : 110.09
SMILES Code : CCCC([O-])=O.[Na+]
Synonyms :
Butyric Acid; NaB; Butanoic acid sodium salt
MDL No. :MFCD00002816
InChI Key :MFBOGIVSZKQAPD-UHFFFAOYSA-M
Pubchem ID :5222465

Safety of Sodium Butyrate

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of Sodium Butyrate

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 156-54-7 ]

[ 156-54-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 125652-55-3 ]
  • [ 156-54-7 ]
  • 1-butyl-3-methylpyridinium butanoate [ No CAS ]
YieldReaction ConditionsOperation in experiment
91% In water; at 40℃;Flow reactor; 5.0 g (0.027 mol) of <strong>[125652-55-3]1-butyl-3-methylpyridinium chloride</strong> was dissolved in 20 g of water at a rate of 300 mul / min, and sodium butanoate 3.10 g (0.028 mol) of the compound was dissolved in 20 g of water to prepare a microreactor controlled at 40 C. at a rate of 293 mul / min. I sent it away. The solution passed through the microreactor was collected and concentrated under reduced pressure to obtain 1-butyl-3-methyltilpyridinium butanoate 5.84 g (91%) of tilpyridinium butanoate was obtained. The analysis
 

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