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Chemical Structure| 24276-84-4 Chemical Structure| 24276-84-4

Structure of Sodium ferulic
CAS No.: 24276-84-4

Chemical Structure| 24276-84-4

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Sodium ferulate is the sodium salt of ferulic acid which is used for the treatment of cardiovascular disease.

Synonyms: Sodium Ferulate; Coniferic acid sodium; Ferulic acid sodium salt

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Product Details of Sodium ferulic

CAS No. :24276-84-4
Formula : C10H9NaO4
M.W : 216.17
SMILES Code : [Na+].COC1=C(O)C=CC(C=CC([O-])=O)=C1
Synonyms :
Sodium Ferulate; Coniferic acid sodium; Ferulic acid sodium salt
MDL No. :MFCD00075727
InChI Key :NCTHNHPAQAVBEB-WGCWOXMQSA-M
Pubchem ID :23669636

Safety of Sodium ferulic

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Related Pathways of Sodium ferulic

GPCR

Isoform Comparison

Biological Activity

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT03092076 Healthy Phase 1 Completed - -
NCT01982734 Pharmacokinetics of New Curcum... More >>in Formulations Safety of New Curcumin Formulations Less << Early Phase 1 Completed - Germany ... More >> University of Hohenheim Stuttgart, Baden-Württemberg, Germany, 70599 Less <<
NCT02150356 Glucose and Lipid Metabolism ... More >> Incretin Hormones Plasma Levels Inflammation, Oxidative Stress and Endothelial Function Less << Not Applicable Completed - Italy ... More >> Dept. Clinical Medicine and Surgery, Federico II University Naples, Italy, 80131 Less <<
NCT01293175 Overweight Not Applicable Completed - Italy ... More >> Department of Food Science Portici, Italy, 80055 Less <<
NCT02944084 Safety After Oral Intake ... More >> Pharmacokinetics After Oral Intake Less << Early Phase 1 Completed - Germany ... More >> University of Hohenheim Stuttgart, Baden-Württemberg, Germany, 70599 Less <<
NCT02353234 Dietary Modification Not Applicable Completed - Italy ... More >> University of Parma - Department of Food Science Parma, Italy, 43125 Less <<
NCT00777543 Healthy Males Not Applicable Completed - Netherlands ... More >> University of Maastricht Maastricht, Netherlands, 6200 MD Less <<
NCT03451760 Behavioral and Psychiatric Sym... More >>ptoms of Dementia Less << Phase 2 Not yet recruiting December 2019 -

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

4.63mL

0.93mL

0.46mL

23.13mL

4.63mL

2.31mL

46.26mL

9.25mL

4.63mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2
The prepared working fluid is recommended to be prepared now and used up as soon as possible in a short period of time. The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1

References

[1]Wang BH, Ou-Yang JP. Pharmacological actions of sodium ferulate in cardiovascular system. Cardiovasc Drug Rev. 2005 Summer;23(2):161-72.

[2]Zhang J, Chen J, et al. Sodium ferulate inhibits neointimal hyperplasia in rat balloon injury model. PLoS One. 2014 Jan 29;9(1):e87561.

[3]Sharifat N, Mohammad Zadeh G, Ghaffari MA, Dayati P, Kamato D, Little PJ, Babaahmadi-Rezaei H. Endothelin-1 (ET-1) stimulates carboxy terminal Smad2 phosphorylation in vascular endothelial cells by a mechanism dependent on ET receptors and de novo protein synthesis. J Pharm Pharmacol. 2017 Jan;69(1):66-72. doi: 10.1111/jphp.12654. Epub 2016 Dec 1. PMID: 27905105.

[4]Jiang G, Fan T. Sodium Ferulate Attenuates Lidocaine-Induced Corneal Endothelial Impairment. Oxid Med Cell Longev. 2018 Jul 8;2018:4967318. doi: 10.1155/2018/4967318. PMID: 30116483; PMCID: PMC6079406.

[5]Brunkwall JS, Stanley JC, Graham LM, Burkel WE, Bergqvist D. Comparison of static incubation versus physiologic perfusion techniques for quantitation of luminal release of prostacyclin and thromboxane in canine arteries and veins. J Surg Res. 1988 Jul;45(1):1-7. doi: 10.1016/0022-4804(88)90013-3. PMID: 3134577.

[6]Qin J, Shang L, Ping AS, Li J, Li XJ, Yu H, Magdalou J, Chen LB, Wang H. TNF/TNFR signal transduction pathway-mediated anti-apoptosis and anti-inflammatory effects of sodium ferulate on IL-1β-induced rat osteoarthritis chondrocytes in vitro. Arthritis Res Ther. 2012 Nov 7;14(6):R242. doi: 10.1186/ar4085. Erratum in: Arthritis Res Ther. 2013;15(3):407. PMID: 23134577; PMCID: PMC3674623.

[7]Qiao Y, He H, Zhang Z, Liao Z, Yin D, Liu D, Yi B, He M. Long-Term Sodium Ferulate Supplementation Scavenges Oxygen Radicals and Reverses Liver Damage Induced by Iron Overloading. Molecules. 2016 Sep 16;21(9):1219. doi: 10.3390/molecules21091219. PMID: 27649133; PMCID: PMC6273935.

 

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