Sulfadiazine Sodium is one of the short-acting sulfonamides used in combination with pyrimethamine to treat toxoplasmosis in patients with acquired immunodeficiency syndrome and in newborns with congenital infections.

Synonyms: Sulfadiazin-natrium; Sulfadiazine sodium; Sulfadiazine(sodium)

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Quality Control of Sulfadiazine sodium Purity: 97% SDS Specification

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NMR

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CNMR

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Product Details of Sulfadiazine sodium

CAS No. :	547-32-0
Formula :	C₁₀H₉N₄NaO₂S
M.W :	272.26
SMILES Code :	O=S(C1=CC=C(N)C=C1)([N-]C2=NC=CC=N2)=O.[Na+]
Synonyms :	Sulfadiazin-natrium; Sulfadiazine sodium; Sulfadiazine(sodium)
MDL No. :	MFCD00067333
InChI Key :	JLDCNMJPBBKAHH-UHFFFAOYSA-N
Pubchem ID :	15899898

Safety of Sulfadiazine sodium

GHS Pictogram:
Signal Word:	Danger
Hazard Statements:	H318-H411
Precautionary Statements:	P280-P305+P351+P338+P310
Class:	9
UN#:	3077
Packing Group:	Ⅲ

Application In Synthesis of Sulfadiazine sodium

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 547-32-0 ]

[ 547-32-0 ] Synthesis Path-Downstream 1~41

2
[ 5335-05-7 ]
[ 547-32-0 ]
4-amino-N-benzoyloxymethyl-N-(2-pyrimidinyl)benzenesulfonamide [ No CAS ]

References: [1]Bioorganic and Medicinal Chemistry,2000,vol. 8,p. 707 - 716.

3
nickel(II) chloride hexahydrate [ No CAS ]
[ 547-32-0 ]
Ni(sulfadiazine)2(H₂O)2*2H₂O [ No CAS ]

References: [1]Synthesis and Reactivity in Inorganic, Metal-Organic, and Nano-Metal Chemistry,2007,vol. 37,p. 653 - 659.

4
copper(II) choride dihydrate [ No CAS ]
[ 547-32-0 ]
[ 1096051-43-2 ]

References: [1]Synthesis and Reactivity in Inorganic, Metal-Organic, and Nano-Metal Chemistry,2007,vol. 37,p. 653 - 659.
[2]Synthesis and Reactivity in Inorganic, Metal-Organic, and Nano-Metal Chemistry,2007,vol. 37,p. 653 - 659.

5
manganese(II) chloride tetrahydrate [ No CAS ]
[ 547-32-0 ]
[ 1096051-49-8 ]

References: [1]Synthesis and Reactivity in Inorganic, Metal-Organic, and Nano-Metal Chemistry,2007,vol. 37,p. 653 - 659.

6
vanadyl(IV) sulphate pentahydrate [ No CAS ]
[ 547-32-0 ]
VO(sulfadiazine)2(H₂O)*H₂O [ No CAS ]

References: [1]Synthesis and Reactivity in Inorganic, Metal-Organic, and Nano-Metal Chemistry,2007,vol. 37,p. 653 - 659.

7
[ 1600-27-7 ]
[ 547-32-0 ]
[ 68-12-2 ]
[mercury(II)(sulfadiazine(-H))2(dimethylformamide)2] [ No CAS ]

References: [1]Polyhedron,2007,vol. 26,p. 967 - 974.

8
zinc(II) chloride hexahydrate [ No CAS ]
[ 547-32-0 ]
[ 1096051-46-5 ]

References: [1]Synthesis and Reactivity in Inorganic, Metal-Organic, and Nano-Metal Chemistry,2007,vol. 37,p. 653 - 659.

9
zinc(II) acetate tetrahydrate [ No CAS ]
[ 547-32-0 ]
[ 1096051-46-5 ]

References: [1]Synthesis and Reactivity in Inorganic, Metal-Organic, and Nano-Metal Chemistry,2007,vol. 37,p. 653 - 659.

10
copper(II) acetate dihydrate [ No CAS ]
[ 547-32-0 ]
[ 1096051-43-2 ]

11
[ 67-56-1 ]
[ 10025-98-6 ]
[ 547-32-0 ]
[ 1096051-55-6 ]

References: [1]Synthesis and Reactivity in Inorganic, Metal-Organic, and Nano-Metal Chemistry,2007,vol. 37,p. 653 - 659.

12
copper(ll) sulfate pentahydrate [ No CAS ]
[ 547-32-0 ]
[ 1096051-43-2 ]

13
[ 10025-99-7 ]
[ 547-32-0 ]
[ 1096051-58-9 ]

References: [1]Synthesis and Reactivity in Inorganic, Metal-Organic, and Nano-Metal Chemistry,2007,vol. 37,p. 653 - 659.

14
ammonium hydroxide [ No CAS ]
[ 543-90-8 ]
[ 547-32-0 ]
Cd(sulfadiazinato)2*2(NH₃) [ No CAS ]

References: [1]Polyhedron,2000,vol. 19,p. 991 - 1004.

15
[ 547-32-0 ]
[ 24540-82-7 ]

References: [1]CrystEngComm,2013,vol. 15,p. 1164 - 1172.

16
zinc(II) chloride hexahydrate [ No CAS ]
[ 547-32-0 ]
[ 107-15-3 ]
2C₁₀H₉N₄O₂S^(1-)*C₆H₂₄N₆Zn⁽²⁺⁾*H₂O [ No CAS ]

References: [1]CrystEngComm,2013,vol. 15,p. 1164 - 1172.

17
[ 21264-30-2 ]
[ 547-32-0 ]
[ 39234-21-4 ]
[Pd(SD)(me-DTC)] [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
85%		General procedure: A solution containing 1 mmol of the respective metal salt was added to sodium sulfadiazine (1mmol, 0.272 g) in 25 mL of distilled water. The mixture was refluxed for 1 h followed by the addition of N-methyl-N-phenyldithiocarbamate (1 mmol, 0.205 g) or N-ethyl-N-phenyldithiocarbamate (1 mmol, 0.219 g) in 25 mL of distilled water. The reaction mixture was further refluxed for 3 h, cool to room temperature and filtered. The product was dried over CaCl2.

References: [1]Bulletin of the Chemical Society of Ethiopia,2013,vol. 27,p. 77 - 84.

18
[ 12080-32-9 ]
[ 547-32-0 ]
[ 39234-21-4 ]
[Pt(SD)(me-DTC)] [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
97%		General procedure: A solution containing 1 mmol of the respective metal salt was added to sodium sulfadiazine (1mmol, 0.272 g) in 25 mL of distilled water. The mixture was refluxed for 1 h followed by the addition of N-methyl-N-phenyldithiocarbamate (1 mmol, 0.205 g) or N-ethyl-N-phenyldithiocarbamate (1 mmol, 0.219 g) in 25 mL of distilled water. The reaction mixture was further refluxed for 3 h, cool to room temperature and filtered. The product was dried over CaCl2.

References: [1]Bulletin of the Chemical Society of Ethiopia,2013,vol. 27,p. 77 - 84.

19
[ 21264-30-2 ]
[ 13074-29-8 ]
[ 547-32-0 ]
[Pd(SD)(et-DTC)] [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
84%		General procedure: A solution containing 1 mmol of the respective metal salt was added to sodium sulfadiazine (1mmol, 0.272 g) in 25 mL of distilled water. The mixture was refluxed for 1 h followed by the addition of N-methyl-N-phenyldithiocarbamate (1 mmol, 0.205 g) or N-ethyl-N-phenyldithiocarbamate (1 mmol, 0.219 g) in 25 mL of distilled water. The reaction mixture was further refluxed for 3 h, cool to room temperature and filtered. The product was dried over CaCl2.

References: [1]Bulletin of the Chemical Society of Ethiopia,2013,vol. 27,p. 77 - 84.

20
[ 12080-32-9 ]
[ 13074-29-8 ]
[ 547-32-0 ]
[Pt(SD)(et-DTC)] [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
92%		General procedure: A solution containing 1 mmol of the respective metal salt was added to sodium sulfadiazine (1mmol, 0.272 g) in 25 mL of distilled water. The mixture was refluxed for 1 h followed by the addition of N-methyl-N-phenyldithiocarbamate (1 mmol, 0.205 g) or N-ethyl-N-phenyldithiocarbamate (1 mmol, 0.219 g) in 25 mL of distilled water. The reaction mixture was further refluxed for 3 h, cool to room temperature and filtered. The product was dried over CaCl2.

References: [1]Bulletin of the Chemical Society of Ethiopia,2013,vol. 27,p. 77 - 84.

21
[ 547-32-0 ]
2C₁₀H₁₀N₄O₂S*2H⁽¹⁺⁾*Cl₂I₂^(2-) [ No CAS ]