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Chemical Structure| 1816294-67-3 Chemical Structure| 1816294-67-3

Structure of SR-4370
CAS No.: 1816294-67-3

Chemical Structure| 1816294-67-3

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SR-4370 is an inhibitor of HDAC, with IC50s of 0.13 μM, 0.58 μM, 0.006 μM, 2.3 μM, and 3.4 μM for HDAC1, HDAC2, HDAC3, HDAC8, and HDAC6, respectively.

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Product Details of SR-4370

CAS No. :1816294-67-3
Formula : C17H18F2N2O
M.W : 304.33
SMILES Code : O=C(C1=CC=C(C2=CC=CC(F)=C2F)C=C1)NNCCCC
MDL No. :MFCD31657386
InChI Key :OSQKWTZHYXRTBG-UHFFFAOYSA-N
Pubchem ID :118418385

Safety of SR-4370

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Related Pathways of SR-4370

epigenetics

Isoform Comparison

Biological Activity

In Vitro:

Cell Line
Concentration Treated Time Description References
J-Lat cells 1 nM to 100 μM 24 h Validation of SR-4370's reactivation ability in a known latency model system, results showed significant reactivation capability PMC7927817
Jurkat-E6-LTR-Tat-EGFP cells 1 nM to 100 μM 24 h Screening for compounds capable of reactivating latent HIV-1, SR-4370 showed high reactivation efficiency and low toxicity PMC7927817

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.29mL

0.66mL

0.33mL

16.43mL

3.29mL

1.64mL

32.86mL

6.57mL

3.29mL

References

 

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