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Chemical Structure| 2254693-15-5 Chemical Structure| 2254693-15-5

Structure of SRX3207
CAS No.: 2254693-15-5

Chemical Structure| 2254693-15-5

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SRX3207 is an orally active dual Syk/PI3K inhibitor with IC50 value of 30nM for Syk. It potently blocks phosphorylation of Syk at 348 site and Y525/526 site. SRX3207 reduced immunosuppressive macrophage polarization and increased infiltration and cytotoxicity of CD8+ T cells in LLC tumors and increased expression of Ifng and Gzmb in 3207 treated LLC tumors.

Synonyms: SRX3207

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Product Details of SRX3207

CAS No. :2254693-15-5
Formula : C29H29N7O3S
M.W : 555.65
SMILES Code : O=C1C2=C(C(C3=CC=C(NC4=NC=CC(N5N=C(C)C(CN6CCC6)=C5)=N4)C=C3)=CS2)OC(N7CCOCC7)=C1
Synonyms :
SRX3207
MDL No. :N/A

Safety of SRX3207

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Related Pathways of SRX3207

RTK
PI3K-AKT

Isoform Comparison

Biological Activity

Target
  • p110γ

    PI3K gamma, IC50:9790 nM

  • p110α

    PI3K alpha, IC50:244 nM

  • p110δ

    PI3K delta, IC50:388 nM

  • BET

    BRD42, IC50:3070 nM

    BRD41, IC50:3070 nM

Protocol

Bio Calculators
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