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Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Chemical Structure| 38194-50-2 Chemical Structure| 38194-50-2
Chemical Structure| 38194-50-2

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Sulindac is a nonsteroidal anti-inflammatory drug (NSAID) and is thought to act on enzymes COX-1 and COX-2, inhibiting prostaglandin synthesis.

Synonyms: MK-231

4.5 *For Research Use Only !

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Product Details of Sulindac

CAS No. :38194-50-2
Formula : C20H17FO3S
M.W : 356.41
SMILES Code : O=C(CC(C1=C2C=CC(F)=C1)=C(/C2=C/C3=CC=C(C=C3)S(C)=O)C)O
Synonyms :
MK-231
MDL No. :MFCD00599589

Safety of Sulindac

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H301-H317-H334-H361
Precautionary Statements:P201-P202-P261-P264-P270-P272-P280-P284-P301+P310+P330-P302+P352-P304+P340-P308+P313-P333+P313-P405-P501
Class:6.1
UN#:2811
Packing Group:

Application In Synthesis of Sulindac

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 38194-50-2 ]

[ 38194-50-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 38194-50-2 ]
  • [ 22795-99-9 ]
  • N-(((S)-1-ethylpyrrolidin-2-yl)methyl)-2-((Z)-5-fluoro-2-methyl-1-(4-(methylsulfinyl)benzylidene)-1H-inden-3-yl)acetamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
91% With N-ethyl-N,N-diisopropylamine; HATU; In acetonitrile; at 20℃;Inert atmosphere; General procedure: (2-(7-Aza-1H-benzotriazole-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate), (HATU) (1.2 equivalents) was added to a solution of acid (1 equivalent), the appropriate amine (1.5 equivalents) and DIEA (2 equivalents) in dry acetonitrile (10 mL) at room temperature under argon atmosphere. The reaction mixture was stirred at room temperature for 1-2 h. Solvent was evaporated under reduced pressure and the crude product was purified using a Teledyne Isco Combiflash Rf purification machine to provide the desired amide in excellent yield.
 

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