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Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Chemical Structure| 951395-08-7 Chemical Structure| 951395-08-7

Structure of Tafamidis meglumine
CAS No.: 951395-08-7

Chemical Structure| 951395-08-7

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Tafamidis binds selectively and with negative cooperativity (K(d)s ~2 nM and ~200 nM) to the two normally unoccupied thyroxine-binding sites of the tetramer, and kinetically stabilizes TTR. 

Synonyms: Fx-1006A

4.5 *For Research Use Only !

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Product Details of Tafamidis meglumine

CAS No. :951395-08-7
Formula : C21H24Cl2N2O8
M.W : 503.33
SMILES Code : O[C@H]([C@H]([C@@H]([C@@H](CO)O)O)O)CNC.O=C(C1=CC=C2N=C(C3=CC(Cl)=CC(Cl)=C3)OC2=C1)O
Synonyms :
Fx-1006A
MDL No. :MFCD28502032
InChI Key :DQJDBUPLRMRBAB-WZTVWXICSA-N
Pubchem ID :24970412

Safety of Tafamidis meglumine

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H360
Precautionary Statements:P201-P202-P281-P308+P313-P405-P501
Class:6.1
UN#:2811
Packing Group:

Isoform Comparison

Biological Activity

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT00694161 Cardiomyopathy PHASE2 COMPLETED 2025-01-10 Emory University School of Med... More >>icine, Atlanta, Georgia, 30322, United States|University of Chicago, Chicago, Illinois, 60637, United States|Johns Hopkins Hospital, Baltimore, Maryland, 21205, United States|Harvard Vanguard Medical Associates, Boston, Massachusetts, 02215, United States|Mayo Clinic, Rochester, Minnesota, 55905, United States|Columbia University, New York, New York, 10032, United States Less <<
NCT00791492 Familial Amyloid Polyneuropath... More >>y|ATTR-PN Less << PHASE2|PHASE3 COMPLETED 2025-10-10 FLENI Departamento de Hepatolo... More >>gía y Transplante de Organos, Buenos Aires, Argentina|FLENI-Hepatology and Organ Transplant Dept., Ciudad de Buenos Aires, C1428AQK, Argentina|Hospital Universitario Clementino Fraga Filho, Rio de Janeiro, Brazil|Service de Neurologie, CHU Henri Mondor, Paris, France|Universitatsklinikum Munster, Transplant Hepatology, Munster, Germany|Servi?o de Neurologia-Hospital de Santa Maria, Lisboa, 1649-035, Portugal|Servicio de Neurologica Piso 7, Hospital de Santa Maria, Lisbon, Portugal|Unidade Clinica de Paramiloidose-Hospital Santo Antonio, Porto, 4099-001, Portugal|Unidade Clinica de Paramiloidose, Hospital Geral de Santo Antonio, Largo Prof Abdel Salazar, Porto, Portugal|Umea University Hospital, Umea, SE-901 85, Sweden|FAP-Teamet Familjar Amyloids, Norrlands universitetssjukhus, Umea, Sweden Less <<
NCT00630864 Transthyretin-associated Amylo... More >>idosis With Polyneuropathy Less << PHASE2 COMPLETED 2025-01-10 Johns Hopkins Hospital, Baltim... More >>ore, Maryland, 21205, United States|CHU de Bicetre, Paris, France|Universitatsklinikum Munster, Transplant Hepatology, Munster, Germany|Centro per lo Studio e la Cura delle Amiloidosi Sistemiche, IRCCS - Policlinico San Matteo, Pavia, 19 - 27100, Italy Less <<

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.99mL

0.40mL

0.20mL

9.93mL

1.99mL

0.99mL

19.87mL

3.97mL

1.99mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

References

 

Historical Records

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